Effectiveness of an Interactive Screen in the Rehabilitation of Neglect in Adults With Subacute Stroke: A Randomized Controlled Trial in Argentina.

NCT07475611 | Enrolling By Invitation DMC

• 1 other identifier: 14/25
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

Hemispatial neglect is one of the most frequent and disabling sequelae after a stroke, particularly following right-hemisphere lesions. Its prevalence ranges from 25% to 80% and is associated with poorer functional outcomes, increased risk of falls, prolonged hospital stays, and lower rates of discharge to home. In response to these challenges, rehabilitation technologies have emerged as promising tools, especially during the subacute phase of stroke, a critical period for neuroplasticity. The MYRO® device-an adjustable interactive screen that enables intensive, task-oriented training-has shown benefits in promoting visual scanning, midline crossing, and sensorimotor integration through personalized exercises with constant feedback. This study aims to evaluate the effectiveness of MYRO® combined with conventional occupational therapy in patients with left hemispatial neglect secondary to subacute stroke. A randomized clinical trial will be conducted with 30 participants assigned to two groups: conventional occupational therapy (OT-C) and occupational therapy plus rehabilitation technology using MYRO® (OT-M). Both groups will receive interventions for four weeks, with assessments at baseline, at the end of the protocol, and at a six-week follow-up. Outcome measures will include the NIHSS, FIM, Catherine Bergego Scale, Cancelation Bells Test, and Line Bisection Test. It is expected that the use of MYRO® will enhance visuospatial attention toward the left hemifield and accelerate functional recovery compared with conventional treatment alone. The results could provide relevant evidence supporting the integration of interactive technology into neurofunctional rehabilitation within the Argentine context.

Conditions

Stroke; Neglect, Hemispatial

Keywords

neglect; stroke; rehabilitation; virtual reality

Outcome Measures

Primary Outcomes (1)

• Catherine Bergego Scale for Neglect

  The Catherine Bergego Scale (CBS) is a functional assessment composed of 10 items, each scored on a 0-3 scale, resulting in a total score ranging from 0 to 30. A score of 0 indicates the absence of neglect, whereas a score of 30 reflects severe unilateral neglect. Higher total scores represent worse performance and greater severity of neglect, while lower scores indicate better functional outcomes. Severity levels are commonly categorized as follows: 1-10 points indicate mild behavioral neglect, 10-20 indicate moderate neglect, and 21-30 represent severe behavioral neglect.

  from the start of treatment until 4 weeks

Study Arms (2)

Neglect Conventional intervenction

OTHER

Conventional occupational therapy intervention for the treatment of neglect

Other: occupational therapy conventional treatment

Neglect Virtual Intervention

EXPERIMENTAL

Use of an interactive screen for neglect rehabilitation

Device: Myro Interactive Screen (Tyromotion) as a tool for occupational therapy approach in patients with unilateral neglect

Interventions

Myro Interactive Screen (Tyromotion) as a tool for occupational therapy approach in patients with unilateral neglect DEVICE

Use of the Myro Interactive Screen (Tyromotion) as a tool for occupational therapy approach in patients with unilateral neglect

Neglect Virtual Intervention

occupational therapy conventional treatment OTHER

Bottom - up, restorative occupational therapy approach to unilateral neglect

Neglect Conventional intervenction

Eligibility Criteria

• Age: 18 Years - 88 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Right-sided stroke. Ischemic or hemorrhagic.
• Currently in the subacute phase of recovery from the event (1 week to \<6 months post-stroke).
• Presence of left hemineglect as determined by the Catherine Bergego Scale and/or Cancel Bells Test and/or Line Bisection Test.
• Age 18 to 88 years.
• Native Spanish speaker.

You may not qualify if:

• Bilateral stroke. Previous strokes.
• Medically unstable condition.
• Previous visual impairments that prevent interaction with the device screen.
• Presence of severe left homonymous hemianopsia. Determined by the total absence of vision in the entire left visual field, evaluated by confrontation visual field testing during the neurological physical examination.
• Severe aphasia that prevents the comprehension of simple instructions that guarantee the completion of the task, determined by an NIHSS scale with a score of 3 points on the aphasia subitem.
• Severe attentional and executive function deficits that prevent the comprehension of simple instructions, determined by the Catherine Bergego Scale and/or Cancel Bells Test and/or Line Bisection Test.

Sponsors & Collaborators

• Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia: lead

Study Sites (1)

FLENI

Buenos Aires, Escobar, 1625, Argentina

Location

Related Publications (2)

• Williams, L. J., Kernot, J., Hillier, S. L., & Loetscher, T. (2021). Subtipos de negligencia espacial, definiciones y herramientas de evaluación: Una revisión de alcance. Frontiers in Neurology, 12, 742365.

  BACKGROUND

• Williams, L., Loetscher, T., Hillier, S., Hreha, K., Jones, J., Bowen, A., & Kernot, J. (2024, mayo). Identifying spatial neglect - an updated systematic review of the psychometric properties of assessment tools in adults post-stroke. Neuropsychological Rehabilitation. https://doi.org/10.1080/09602011.2024.2346212

  BACKGROUND

Related Links

• Tyromotion Device

MeSH Terms

Conditions

Stroke; Perceptual Disorders

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Neurobehavioral Manifestations; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Vanina Lado

  Fundacion para la Lucha de las Enfermedades Neurologicas de la Infancia, Sede Escobar

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Occupational Therapy Coordinator

Model Details: ensayo clínico aleatorizado y con dos ramas

Study Record Dates

• First Submitted: March 5, 2026
• First Posted: March 16, 2026
• Study Start: October 1, 2025
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): May 1, 2027
• Last Updated: March 16, 2026

Record last verified: 2026-03

Locations

AR (1)