NCT07468929|Recruiting
Serum Inflammatory Protein Concentration During Dental Treatment
Systemic Molecular Markers of Surgical Trauma in Periodontitis/Peri-implantitis Patients
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Systemic Molecular Markers of Surgical Trauma in Periodontitis/Peri-implantitis Patients
Sponsor study identifier
observational
30
1 country
1
Study Start
July 13, 2026
Actual (reported)Primary Completion
June 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
June 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
The goal of this observational study is to study the molecular markers of stress in blood samples from people who are having periodontal surgery. The main question it aims to answer are:
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
June 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 27, 2026
Actual (reported)March 13, 2026
Actual (reported)July 13, 2026
Actual (reported)June 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
June 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Serum CRP concentration (pg/ml)
The investigators will study CRP concentration (pg/ml) in circulatory inflammatory mediator content during dental treatment by drawing peripheral blood samples, isolating serum and running a protein assay to detect inflammatory protein content in concentration (pg/ml) level.
Immediately prior to procedure; approximately midway through the procedure; immediately after procedure ends;
Seum IL-1 concentration (pg/ml)
The investigators will measure serum IL-1 concentration (pg/ml) in blood samples obtained immediately before, during and immediately after the dental procedure.
During dental procedure intervention
Serum TNF concentration (pg/ml)
The investigators will measure serum TNF concentration (pg/ml) during dental procedure.
Blood samples will be obtained immediately before, during and immediately after dental procedure intervention.
Sedation Effect
Immediately prior to procedure; approximately midway through the procedure; immediately after procedure ends;
Tissue change (mm)
Approximately 30 days after the procedure
Recruited from patients who have already received active treatment to control their disease and are now in periodontal maintenance program (regular cleaning).
Recruited from patients who are receiving non-surgical deep cleaning (debridement under local anesthesia)
Recruited from patients who are treatment planned for periodontal/peri-implant surgical interventions.
Blood samples will be obtained before the start of the procedure, the midpoint of the procedure, and the end of the procedure.
Periodontal/peri-implant surgical interventions, with or without IV sedation, as based on treatment needs
Study population will be created from the general patient population that is referred to The Ohio State University College of Dentistry's Advanced Training in Periodontology clinics or already established patients in our clinics. These are adult patients suffering from gum disease, losing teeth due to disease and/or having disease around their dental implants. There will be two groups: Control group 1 will be recruited from the patients who have already received active treatment to control their disease and are now in periodontal maintenance program (regular cleaning). Control group 2 will be recruited from patients who are receiving non-surgical deep cleaning (debridement under local anesthesia) and Test group will be recruited from patients who are treatment planned for periodontal/peri-implant surgical interventions.
The Ohio State University Graduate Periodontics Clinic
Columbus, Ohio, 43210, United States
Binnaz Leblebibioglu, DDS, MS, PhD
Ohio State University
First Submitted
January 27, 2026
First Posted
March 13, 2026
Study Start
July 13, 2026
Actual (reported)Primary Completion
June 2027
EstimatedStudy Comparing Two Different Methods of Treating Periodontal Disease
Regular cleaning to maintain health after surgical treatment for periodontal disease
Debridement under local anesthesia, as based on treatment needs
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Contact the study team to confirm eligibility.
Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
June 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
September 11, 2026
Record last verified: 2026-08
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Source: ClinicalTrials.gov.
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