Trials Sponsors Conditions Drugs Pricing

Conditions

Periodontal Surgery

Keywords

Local anestheticPain survey

Outcome Measures

Primary Outcomes (1)

Post-operative pain measured with Numeric Rating Scale NRS-21 pain scale
Pain perceived at regular time intervals using a Visual Analogue Scale (NRS-21) rating their pain at specific time points on a scale from 0 to 10 with 0.5 points in between. A higher score indicates more pain.
3 to 168 hours

Secondary Outcomes (3)

Time for numbness to wear off
3 to 168 hours
Number of of anti-inflammatory tablets taken
Baseline to 7 days
Number of analgesic tablets taken
Baseline to 7 days

Study Arms (2)

Adjunctive long acting local anesthesia post surgery

EXPERIMENTAL

The experimental group will receive a longer lasting formulation of bupivacaine (liposomal bupivacaine) as an adjunctive local infiltration

Drug: Liposomal Bupivacaine (EXPAREL®)/Bupivacaine

Adjunctive standard of care local anesthetic

ACTIVE COMPARATOR

The control group will receive a commonly used in dentistry local anesthetic (0.5% bupivacaine HCL) as an adjunctive analgesic after the end of the procedure.

Drug: 0.5% Bupivacaine HCl

Interventions

0.5% Bupivacaine HClDrug

4 ml of bupivacaine 0.5% will be injected adjacent to the surgical site post-surgery

Adjunctive standard of care local anesthetic

Liposomal Bupivacaine (EXPAREL®)/BupivacaineDrug

4 ml of Liposomal bupivacaine 13.3 mg/ml is injected adjacent to the surgical site post-surgery

Adjunctive long acting local anesthesia post surgery

Eligibility Criteria

Age18 Years - 89 Years

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

Ability of subject to understand and the willingness to sign a written informed consent document.
Males and females; Age 18 to 89 years old

Sponsors & Collaborators

The University of Texas Health Science Center at San Antonio
Otherlead

Study Sites (1)

University of Texas Health Science Center at San Antonio

San Antonio, Texas, 78229, United States

MeSH Terms

Interventions

Bupivacaine

Intervention Hierarchy (Ancestors)

AnilidesAmidesOrganic ChemicalsAniline CompoundsAmines

Study Officials

Angela Palaiologou-Gallis, DDS, MS
The University of Texas Health Science Center at San Antonio
PRINCIPAL INVESTIGATOR

Enrollment

58 participants (actual enrollment reported by the registry).

Study Design

Study Type: interventional
Phase: phase 1 2
Allocation: RANDOMIZED
Masking: DOUBLE
Who Masked: PARTICIPANT, CARE PROVIDER
Masking Details: Subjects will be randomized to one of the two groups with simple randomization. Prior to the beginning of the surgical procedure, the PI will request that a faculty member not involved in the case randomly select a sealed envelope with the intervention named inside and hand it to the PI. The PI will prepare the solution selected in a non-labeled syringe and hand it to the surgeon. The surgeon, patient and faculty staffing the case will be blinded as to the contents of the syringe
Purpose: TREATMENT
Intervention Model: PARALLEL
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Professor and Program Director, Graduate Periodontics

Study Record Dates

First Submitted

July 21, 2026

The Anesthetic and Analgesic Effect of Adjunct Liposomal Bupivacaine in Periodontal Surgical Procedures

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

Primary Completion

Study Completion

First Submitted

First Posted

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (3)

Study Arms (2)

Adjunctive long acting local anesthesia post surgery

Adjunctive standard of care local anesthetic

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Interventions

Intervention Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

Primary Completion

Study Completion

First Submitted

First Posted

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (3)

Study Arms (2)

Adjunctive long acting local anesthesia post surgery

Adjunctive standard of care local anesthetic

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Interventions

Intervention Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations