Influence of Individual Traits on Adaptation Processes in Individuals With Alcohol Use Disorder

NCT07468825 | Not Yet Recruiting

• 2 other identifiers: APHP2517892025-A02680-49
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Alcohol Use Disorder (AUD) is a chronic condition that affects behavior, decision-making, and the ability to adapt to changing situations. While many studies have examined AUD from medical and social perspectives, less is known about how individual psychological traits influence the way people with AUD respond to uncertainty and adapt their behavior. This study aims to better understand how personal characteristics such as anxiety, self-esteem, sensitivity to reward and punishment, perfectionism, and cognitive abilities may influence adaptation processes in individuals with AUD. Participants receiving usual care at Paul Brousse Hospital will be invited to take part in a single experimental session lasting about 45 minutes. During this session, they will complete:

• A computerized learning task in which they respond to visual stimuli and receive feedback on their performance
• Standardized questionnaires assessing psychological traits and cognitive functioning The learning task is designed to evaluate how participants adjust their behavior when the rules of the task change unexpectedly. Researchers will measure how performance changes in response to uncertainty and examine how these changes relate to individual psychological characteristics. This research does not modify participants' medical care and involves no medication or invasive procedures. By improving understanding of the cognitive and behavioral mechanisms involved in Alcohol Use Disorder, the study may help advance scientific knowledge about how individuals adapt to uncertainty and inform future research in addiction and mental health.

Conditions

Alcohol Use Disorder; Cognition Disorders

Keywords

Alcohol Use Disorder; Addictive Behaviors; Decision Making; Cognitive Adaptation; Behavioral Flexibility; Uncertainty Processing; Exploration-Exploitation Tradeoff; Neurocognitive Processes; Personality Traits; Psychological Assessment; Computerized Cognitive Task

Outcome Measures

Primary Outcomes (1)

• Uncertainty Cost Index During Behavioral Adaptation Task

  Uncertainty cost index. Exploration-exploitation behaviors are inferred from the percentage of correct responses obtained during the CHEAT phase of the computerized task. For each participant, the difference in accuracy rate between the end of the learning phase and the beginning of the CHEAT phase is calculated. This difference (Δ) defines the uncertainty cost index and reflects exploratory behavioral responses to the introduction of misleading feedback.

  At the end of the learning phase and at the beginning of the uncertainty phase during the single study session (approximately 45 minutes)

Secondary Outcomes (1)

• Correlation Between Uncertainty Cost Index and Psychometric Trait Scores

  During the single study session (approximately 45 minutes)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients diagnosed with Alcohol Use Disorder (DSM-5) receiving outpatient care in the Psychiatry and Addiction Department

You may qualify if:

• Adults aged 18 years or older
• Patients receiving care for Alcohol Use Disorder at the Psychiatry and Addiction Unit of Paul Brousse Hospital
• No objection to participation in the study

You may not qualify if:

• Diagnosed neurological disorder
• Patient covered by State Medical Assistance (AME)
• Individuals under legal protection measures (guardianship, curatorship, or legal safeguard)
• Individuals deprived of liberty by judicial or administrative decision
• Pregnant or breastfeeding women
• Psychiatric disorders that could compromise proper study participation (excluding Alcohol Use Disorder)

Sponsors & Collaborators

• Assistance Publique - Hôpitaux de Paris: lead

Study Sites (1)

CHU Bicêtre

Le Kremlin-Bicêtre, France

Location

MeSH Terms

Conditions

Alcoholism; Cognition Disorders; Behavior, Addictive

Condition Hierarchy (Ancestors)

Alcohol-Related Disorders; Substance-Related Disorders; Chemically-Induced Disorders; Mental Disorders; Neurocognitive Disorders; Compulsive Behavior; Impulsive Behavior; Behavior

Central Study Contacts

Catherine MARTELLI, Dr

CONTACT

145593372; catherine.martelli@aphp.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 9, 2026
• First Posted: March 13, 2026
• Study Start: April 1, 2026
• Primary Completion: April 1, 2026
• Study Completion (Estimated): April 1, 2027
• Last Updated: March 13, 2026

Record last verified: 2026-03

Locations

FR (1)