Postoperative Pain Will be Compared in Cholecystectomy Patients: Half Receiving TAP Block and Half Without it.

NCT07465406 | Completed

• 1 other identifier: DarulSehatH
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This study compares the effectiveness of a Transversus Abdominis Plane (TAP) block in reducing post-operative pain for patients undergoing laparoscopic cholecystectomy. Sixty patients were divided into two groups: one group received a TAP block with a local anesthetic at the end of surgery, and the control group did not. The main goal was to see if the TAP block significantly lowers pain scores (measured on a scale of 0 to 10) within the first 12 hours after surgery and if it reduces the need for additional pain-relief medications.

Conditions

Cholelithiasis; Pain, Postoperative

Keywords

Laparoscopic Cholecystectomy; TAP Block; Post Operative Pain; Gallbladder; Post Operative Opioid Consumption; Visual Analog Scale; ERAS

Outcome Measures

Primary Outcomes (1)

• Visual Analog Scale (VAS) Score for Pain

  A subjective psychometric response scale used to measure pain intensity. It consists of a 10 cm line where 0 represents "no pain" and 10 represents "the worst pain imaginable.".

  12 hours post-operation

Secondary Outcomes (1)

• Time for First Request of Rescue Analgesia

  Within the first 24 hours post-operation.

Study Arms (2)

TAP Block Group

EXPERIMENTAL

Patients in this group received a Transversus Abdominis Plane (TAP) block at the end of the laparoscopic cholecystectomy but before extubation.

Drug: Bupivacaine 0.25%

Control Group (The No TAP Block Group)

OTHER

Patients in this group underwent laparoscopic cholecystectomy under the same general anesthesia protocol but did not receive a TAP block

Other: Standard Post-Operative Care

Interventions

Bupivacaine 0.25% DRUG

Transversus Abdominis Plane (TAP) block administered by injecting 20ml of 0.25% Bupivacaine between the internal oblique and transversus abdominis muscles.

TAP Block Group

Standard Post-Operative Care OTHER

Patients received the routine post-operative analgesia protocol of the hospital (e.g., IV Ketorolac or Paracetamol) without the administration of a TAP block

Control Group (The No TAP Block Group)

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Patients aged 18-60 years
• Both genders
• Patients diagnosed with Cholelithiasis in accordance with operational definition and planned to undergo Laparoscopic Cholecystectomy

You may not qualify if:

• Patients with ASA of ≥ 3
• Patients diagnosed with acute cholecystitis, empyema, mucocele or perforated gall bladder
• Patients planned to undergo laparoscopic cholecystectomy alongside other abdominal procedures
• Patients with body mass index of ≥ 35 Kg/m2
• Patients with history of coagulation disorders like hemophilia or those with history of anti-platelet drugs use in last 2 weeks
• Pregnant females

Sponsors & Collaborators

• Darul Sehat Hospital: lead

Study Sites (1)

Darul Sehat Hospital- Liaquat College of Medicine & Dentistry.

Karachi, Pakistan

Location

MeSH Terms

Conditions

Cholelithiasis; Pain, Postoperative

Condition Hierarchy (Ancestors)

Biliary Tract Diseases; Digestive System Diseases; Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Surgical Resident -FCPS Trainee

Study Record Dates

• First Submitted: March 7, 2026
• First Posted: March 11, 2026
• Study Start: March 11, 2025
• Primary Completion: August 11, 2025
• Study Completion: August 11, 2025
• Last Updated: March 13, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)