NCT07461688

Brief Summary

Motor imagery is a cognitive technique in which individuals mentally rehearse a movement without physically performing it. However, individuals with low imagery ability may not fully benefit from traditional motor imagery training. Virtual reality (VR) may enhance imagery vividness by providing immersive visual feedback. The purpose of this study is to compare the effects of immersive VR-based motor imagery, action observation combined with motor imagery, kinesthetic motor imagery alone, and a control condition on imagery ability, muscle strength, and muscle activation. Thirty-two healthy male participants will be assigned to one of four parallel groups based on imagery ability levels. All participants will complete a 4-week unilateral leg extension resistance training program (three sessions per week at 80% of one-repetition maximum). During each session, participants will perform their assigned imagery protocol. Primary outcomes include changes in imagery ability assessed by the Movement Imagery Questionnaire-3. Secondary outcomes include isokinetic quadriceps peak torque, average power, and surface electromyography activity of the rectus femoris, vastus medialis, and vastus lateralis muscles. The findings of this study may provide insight into whether immersive VR can enhance the effectiveness of motor imagery training in individuals with low imagery ability.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
32

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Aug 2025

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 12, 2025

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 25, 2025

Completed
26 days until next milestone

Study Completion

Last participant's last visit for all outcomes

January 20, 2026

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

March 3, 2026

Completed
7 days until next milestone

First Posted

Study publicly available on registry

March 10, 2026

Completed
Last Updated

March 10, 2026

Status Verified

March 1, 2026

Enrollment Period

5 months

First QC Date

March 3, 2026

Last Update Submit

March 6, 2026

Conditions

Keywords

Motor ImageryVirtual RealityIsokinetic strengthSurface ElectromyographyResistance TrainingImagery Ability

Outcome Measures

Primary Outcomes (1)

  • Change in Imagery Ability (MIQ-3 Total Score)

    Imagery ability will be assessed using the Movement Imagery Questionnaire-3 (MIQ-3). The total score change from baseline to post-intervention will be analyzed.

    Baseline to 4 Weeks

Secondary Outcomes (2)

  • Isokinetic Quadriceps Strength (60°/s, 120°/s)

    Baseline to 4 Weeks

  • Surface EMG Activity (%MVIC)

    Baseline to 4 Weeks

Study Arms (4)

Action Observation + Motor Imagery (AOMI)

EXPERIMENTAL

Participants perform action observation combined with kinesthetic motor imagery prior to each resistance training session for 4 weeks.

Behavioral: Action Observation + Motor Imagery

Kinesthetic Motor Imagery

EXPERIMENTAL

Participants perform kinesthetic motor imagery alone prior to each resistance training session for 4 weeks.

Behavioral: Behavioral: Kinesthetic Motor Imagery

Control

ACTIVE COMPARATOR

Participants perform relaxation imagery prior to each resistance training session for 4 weeks.

Behavioral: Relaxation Imagery (Control)

Immersive Virtual Reality-Based Motor Imagery

EXPERIMENTAL

Participants perform immersive first-person virtual reality-based motor imagery prior to each training session. The VR environment provides visual simulation of unilateral leg extension movements from a first-person perspective. The intervention is administered three times per week for 4 weeks before resistance training.

Behavioral: Immersive Virtual Reality-Based Motor Imagery

Interventions

VR Motor Imagery - Intervention Description Participants perform immersive first-person virtual reality-based motor imagery prior to each training session. The intervention is administered three times per week for 4 weeks before resistance training.

Immersive Virtual Reality-Based Motor Imagery

Participants observe a video demonstration of unilateral leg extension while simultaneously performing kinesthetic motor imagery of the movement prior to each resistance training session, three times per week for four weeks.

Action Observation + Motor Imagery (AOMI)

Participants perform kinesthetic motor imagery of unilateral leg extension without visual assistance prior to each resistance training session, three times per week for four weeks.

Kinesthetic Motor Imagery

Participants perform relaxation-based imagery unrelated to strength training prior to each resistance training session, three times per week for four weeks.

Control

Eligibility Criteria

Age18 Years - 35 Years
Sexmale(Gender-based eligibility)
Gender Eligibility DetailsEligible participants must be biologically male and self-identify as male.
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Healthy male individuals aged 18-30 years No participation in a structured lower-limb resistance training program within the previous 6 months No prior experience with structured motor imagery training Provided written informed consent

You may not qualify if:

  • History of lower-limb musculoskeletal injury or surgery within the past 6 months Neurological disorders affecting motor control Visual or vestibular impairments preventing safe use of virtual reality equipment Current use of medications affecting neuromuscular performance Any medical condition contraindicating resistance training

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Ege University

Izmir, Bornova, 35355, Turkey (Türkiye)

Location

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
PARALLEL
Model Details: This is a 4-week, parallel-group interventional study including four arms: immersive virtual reality-based motor imagery, action observation combined with motor imagery, kinesthetic motor imagery alone, and a control condition. Participants are allocated to one group based on imagery ability levels and remain in the same group throughout the intervention period. No crossover between groups occurs.
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Research Assistant

Study Record Dates

First Submitted

March 3, 2026

First Posted

March 10, 2026

Study Start

August 12, 2025

Primary Completion

December 25, 2025

Study Completion

January 20, 2026

Last Updated

March 10, 2026

Record last verified: 2026-03

Data Sharing

IPD Sharing
Will share

De-identified individual participant data (IPD) underlying the primary and secondary outcome measures, including MIQ-3 scores, isokinetic peak torque values, average power, and normalized sEMG data, will be shared. Demographic variables necessary for replication (age and body mass) will also be included.

Shared Documents
STUDY PROTOCOL, SAP
Time Frame
Data will be available beginning 6 months following publication of the primary results and will remain available for 5 years.
Access Criteria
Access to de-identified individual participant data will be granted to qualified researchers upon reasonable request to the corresponding author. Requests must include a brief research proposal outlining the intended use of the data. Data will be shared following approval by the study investigators and in accordance with institutional and ethical guidelines.

Locations