NCT07460999

Brief Summary

People who have undergone curative surgery for non-small cell lung cancer (NSCLC) often experience reduced quality of life (QoL), a high burden of symptoms, and physical deconditioning. Current Danish rehabilitation offers are heterogeneous and inconsistent and not tailored to the specific needs of this population. Additionally, some patients continue to suffer from persistent physical symptoms months or even years after surgery, yet no targeted support is currently available for them. Singing - delivered as a structured form of training - has shown benefits in improving both physical and psychological outcomes in individuals with chronic obstructive pulmonary disease (COPD). Although singing has not yet been studied in NSCLC patients, the two conditions share overlapping symptoms and characteristics. Therefore, the present study aims to explore whether a singing-based intervention can help reduce symptom burden and improve physical function and QoL in NSCLC patients 6 to 18 months post-surgery. To test this, a multi-centre randomised controlled trial (RCT) will be conducted, comparing a singing intervention to usual care. Given that travel and distance often pose significant barriers to participation, the intervention will be delivered online.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
100

participants targeted

Target at P50-P75 for not_applicable nonsmall-cell-lung-cancer

Timeline
14mo left

Started Mar 2026

Shorter than P25 for not_applicable nonsmall-cell-lung-cancer

Geographic Reach
1 country

5 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress28%
Mar 2026Oct 2027

First Submitted

Initial submission to the registry

January 20, 2026

Completed
1 month until next milestone

Study Start

First participant enrolled

March 1, 2026

Completed
9 days until next milestone

First Posted

Study publicly available on registry

March 10, 2026

Completed
1.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2027

Expected
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2027

Last Updated

April 2, 2026

Status Verified

March 1, 2026

Enrollment Period

1.1 years

First QC Date

January 20, 2026

Last Update Submit

March 27, 2026

Conditions

Non-Small Cell Lung CancerChronic Obstructive Lung Disease

Keywords

lung cancerrehabilitationsingingonline trainingphysical capacityquality of lifesymptom burdenairway physiologyphysiologysix-minute walk test

Outcome Measures

Primary Outcomes (3)

  • Change in Physical capacity

    Assessed with the Six Minute Walking Test (6MWT) (assessor-collected) , measured in meters walked in 6 minutes. Minimal important difference: \>30 m.

    Changes pre-post 10 weeks (measured at all assessment points).

  • Perceived exertion

    Measured using BORG CR-10 dyspnoea scale (self-reported). The scale ranges from 0 to 10 points, where 0 represents no exertion/dyspnoea and 10 represents maximal exertion/dyspnoea. Minimal important difference: 1 point.

    Changes measured before and after performance of 6MWT; Changes pre-post 10 weeks (measured at all assessment points).

  • Change in Health-related quality of life (HRQoL)

    St. George's Respiratory Questionnaire (SGRQ) (self-reported questionnaire). SGRQ has 50 items with 76 weighted responses and four scores: Total, Symptom, Activity, Impact. Each score ranges from 0 to 100, with 100 representing worst possible health status and 0 best possible. Minimal important differnence: -4 units.

    Changes pre-post 10 weeks (measured at all assessment points).

Secondary Outcomes (12)

  • Change in Quality of life

    Pre-post 10 weeks

  • Change in Symptoms burden

    Changes pre-post 10 weeks (measured at all assessment points).

  • Change in symptoms burden

    Changes pre-post 10 weeks (measured at all assessment points).

  • Change in symptoms burden: Dyspnoea

    Changes pre-post 10 weeks (measured at all assessment points).

  • Change in symptoms burden: Breathing vigilance

    Changes pre-post 10 weeks (measured at all assessment points).

  • +7 more secondary outcomes

Other Outcomes (3)

  • Resting blood samples

    Changes pre-post 10 weeks (measured at all assessment points).

  • Acute physiological response to maximal exercise (VO2max)

    Changes pre-post 10 weeks (measured at all assessment points).

  • Peripheral oxygenation

    Changes pre-post 10 weeks (measured at all assessment points).

Study Arms (2)

Intervention: Singing training (Singing for Lung Health (SLH))

EXPERIMENTAL

10 weeks of singing training (conducted according to the Singing for Lung Health (SLH) approach). The singing training will be delivered online (1 1/2 hour twice a week) by professional singing teachers specifically trained and experienced within SLH. Sessions include physical, vocal, and breathing exercises and musical repertoire. Besides, movement, dancing, and artefacts for playful games are included along with singing. Each session consists of 20 min physical warm-ups, 20 min vocal warm-up with rhythm and pitch games, 40 min singing (incl. break), and 10 min cool-down. Participants are allowed to participate in additional offer of structured or unstructured offer physical exercise training and/or singing along with the project.

Behavioral: Singing training (Singing for Lung Health (SLH))

Control group: 1) Usual care, followed by Singing training (Singing for Lung Health (SLH))

OTHER

10 weeks of usual care (i.e., no specific additional intervention above those which the person usually engages with), followed by 10 weeks of singing training (conducted according to the Singing for Lung Health (SLH) approach). The singing training will be delivered online (1 1/2 hour twice a week) by professional singing teachers specifically trained and experienced within SLH. Sessions include physical, vocal, and breathing exercises and musical repertoire. Besides, movement, dancing, and artefacts for playful games are included along with singing. Each session consists of 20 min physical warm-ups, 20 min vocal warm-up with rhythm and pitch games, 40 min singing (incl. break), and 10 min cool-down. Participants are allowed to participate in additional offer of structured or unstructured offer physical exercise training and/or singing along with the project.

Behavioral: Singing training (Singing for Lung Health (SLH))Behavioral: Control group: Usual care

Interventions

Singing training (Singing for Lung Health (SLH))BEHAVIORAL

10 weeks of singing training (conducted according to the Singing for Lung Health (SLH) approach). The singing training will be delivered online (1 1/2 hour twice a week) by professional singing teachers specifically trained and experienced within SLH. Sessions include physical, vocal, and breathing exercises and musical repertoire. Besides, movement, dancing, and artefacts for playful games are included along with singing. Each session consists of 20 min physical warm-ups, 20 min vocal warm-up with rhythm and pitch games, 40 min singing (incl. break), and 10 min cool-down.

Control group: 1) Usual care, followed by Singing training (Singing for Lung Health (SLH))Intervention: Singing training (Singing for Lung Health (SLH))
Control group: Usual careBEHAVIORAL

The control group will receive usual care, i.e., no specific additional intervention above those which the person usually engages with.

Control group: 1) Usual care, followed by Singing training (Singing for Lung Health (SLH))

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Patients who display persistent symptoms 6-18 months (+/- one month) after surgical resection of localised lung cancer with video-assisted thoracoscopy (VATS) will be invited to participate in the study.
  • Persistent symptoms, i.e., an EORTC-QLQ-C30 symptom domain score (in any item) of ≥2 (="clinically relevant symptom or problem that should have healthcare professional attention"),
  • Surgery for stage I lung cancer 6-18 months (+/- one month) earlier,
  • Motivated for participating in the project (and acceptance of randomisation procedure),
  • Access to a computer or a tablet with internet access,
  • Ability to speak and understand Danish,
  • Acceptance of the scheduled times of the singing intervention twice a week.

You may not qualify if:

  • Unstable coronary diseases,
  • Severe cognitive disabilities (e.g., dementia),
  • Indication for adjuvant chemotherapy or other antineoplastic therapy,
  • Signs of lung cancer recurrence at regular follow-up CT scan.
  • No previous singing experience or musical competence is required. Participants will be informed that they are allowed to participate in additional offer of structured or unstructured offer physical exercise training and/or singing along with the project.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (5)

August Krogh Section for Molecular and Human Physiology, Department of Nutrition, Exercise, and Sports, Faculty of Health and Medical Sciences, University of Copenhagen

Copenhagen, 2100, Denmark

RECRUITING

Department of Respiratory Medicine, Bispebjerg Hospital

Copenhagen, 2400, Denmark

RECRUITING

Department of Medicine Roskilde and Næstved, Zealand University Hospital

Næstved, 4700, Denmark

RECRUITING

Department of Respiratory Medicine, Odense University Hospital

Odense, 5000, Denmark

RECRUITING

Department of Respiratory Medicine, Lillebaelt Hospital

Vejle, 7100, Denmark

RECRUITING

Related Publications (54)

  • Bohannon RW, Crouch R. Minimal clinically important difference for change in 6-minute walk test distance of adults with pathology: a systematic review. J Eval Clin Pract. 2017 Apr;23(2):377-381. doi: 10.1111/jep.12629. Epub 2016 Sep 4. PMID: 27592691.

    BACKGROUND

  • Granger CL, Holland AE, Gordon IR, Denehy L. Minimal important difference of the 6-minute walk distance in lung cancer. Chron Respir Dis. 2015 May;12(2):146-54. doi: 10.1177/1479972315575715. Epub 2015 Mar 6.

    PMID: 25749346BACKGROUND

  • Holland AE, Nici L. The return of the minimum clinically important difference for 6-minute-walk distance in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2013 Feb 15;187(4):335-6. doi: 10.1164/rccm.201212-2191ED. PMID: 23418323.

    BACKGROUND

  • Han B, Chen Z, Ruan B, Chen Y, Lv Y, Li C, Yu L. Effects of Inspiratory Muscle Training in People with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis. Life (Basel). 2024 Nov 12;14(11):1470. doi: 10.3390/life14111470. PMID: 39598268; PMCID: PMC11595718.

    BACKGROUND

  • Del Corral T, Fabero-Garrido R, Plaza-Manzano G, Fernández-de-Las-Peñas C, Navarro-Santana MJ, López-de-Uralde-Villanueva I. Minimal Clinically Important Differences in Inspiratory Muscle Function Variables after a Respiratory Muscle Training Programme in Individuals with Long-Term Post-COVID-19 Symptoms. J Clin Med. 2023 Apr 5;12(7):2720. doi: 10.3390/jcm12072720. PMID: 37048804; PMCID: PMC10095020.

    BACKGROUND

  • Gosselink R, De Vos J, van den Heuvel SP, Segers J, Decramer M, Kwakkel G. Impact of inspiratory muscle training in patients with COPD: what is the evidence? Eur Respir J. 2011 Feb;37(2):416-25. doi: 10.1183/09031936.00031810. PMID: 21282809.

    BACKGROUND

  • Donohue JF. Minimal clinically important differences in COPD lung function. COPD. 2005 Mar;2(1):111-24. doi: 10.1081/copd-200053377.

    PMID: 17136971BACKGROUND

  • Mujovic N, Mujovic N, Subotic D, Ercegovac M, Milovanovic A, Nikcevic L, Zugic V, Nikolic D. Influence of Pulmonary Rehabilitation on Lung Function Changes After the Lung Resection for Primary Lung Cancer in Patients with Chronic Obstructive Pulmonary Disease. Aging Dis. 2015 Nov 17;6(6):466-77. doi: 10.14336/AD.2015.0503. eCollection 2015 Nov.

    PMID: 26618048BACKGROUND

  • Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983 Jun;67(6):361-70. doi: 10.1111/j.1600-0447.1983.tb09716.x.

    PMID: 6880820BACKGROUND

  • Araújo Oliveira AL, Andrade L, Marques A. Minimal clinically important difference and predictive validity of the mMRC and mBorg in acute exacerbations of COPD. Physiotherapists. European Respiratory Society; 2017; p. PA4705. DOI: 10.1183/1393003.congress-2017.PA4705.

    BACKGROUND

  • Ferrer M, Villasante C, Alonso J, Sobradillo V, Gabriel R, Vilagut G, Masa JF, Viejo JL, Jiménez-Ruiz CA, Miravitlles M. Interpretation of quality of life scores from the St George's Respiratory Questionnaire. Eur Respir J. 2002 Mar;19(3):405-13. doi: 10.1183/09031936.02.00213202. PMID: 11936515.

    BACKGROUND

  • Jones PW. St. George's Respiratory Questionnaire: MCID. COPD. 2005 Mar;2(1):75-9. doi: 10.1081/copd-200050513. PMID: 17136966.

    BACKGROUND

  • Bergman B, Aaronson NK, Ahmedzai S, Kaasa S, Sullivan M. The EORTC QLQ-LC13: a modular supplement to the EORTC Core Quality of Life Questionnaire (QLQ-C30) for use in lung cancer clinical trials. EORTC Study Group on Quality of Life. Eur J Cancer. 1994;30A(5):635-42. doi: 10.1016/0959-8049(94)90535-5. PMID: 8080679.

    BACKGROUND

  • Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc. 1982;14(5):377-81.

    PMID: 7154893BACKGROUND

  • Borg G. Perceived exertion as an indicator of somatic stress. Scand J Rehabil Med. 1970;2(2):92-8. PMID: 5523831.

    BACKGROUND

  • Slade SC, Dionne CE, Underwood M, Buchbinder R, Beck B, Bennell K, Brosseau L, Costa L, Cramp F, Cup E, Feehan L, Ferreira M, Forbes S, Glasziou P, Habets B, Harris S, Hay-Smith J, Hillier S, Hinman R, Holland A, Hondras M, Kelly G, Kent P, Lauret GJ, Long A, Maher C, Morso L, Osteras N, Peterson T, Quinlivan R, Rees K, Regnaux JP, Rietberg M, Saunders D, Skoetz N, Sogaard K, Takken T, van Tulder M, Voet N, Ward L, White C. Consensus on Exercise Reporting Template (CERT): Modified Delphi Study. Phys Ther. 2016 Oct;96(10):1514-1524. doi: 10.2522/ptj.20150668. Epub 2016 May 5.

    PMID: 27149962BACKGROUND

  • Philip, Keir E J et al. An online breathing and wellbeing programme (ENO Breathe) for people with persistent symptoms following COVID-19: a parallel-group, single-blind, randomised controlled trial. The Lancet Respiratory Medicine, Volume 10, Issue 9, 851 - 862. DOI: 10.1016/S2213-2600(22)00125-4 External Link

    BACKGROUND

  • Smallwood N, Pascoe A, Vogrin S, Philip J. SINFONIA study protocol: a phase II/III randomised controlled trial examining benefits of guided online group singing in people with chronic obstructive pulmonary disease and interstitial lung disease and their carers. Respir Res. 2022 Aug 16;23(1):208. doi: 10.1186/s12931-022-02133-3. PMID: 35974347; PMCID: PMC9380685.

    BACKGROUND

  • Philip K, Buttery S, Bowen S, et alS86 A single-blind, multicentre, multinational, randomised controlled trial of online singing for Lung Health (SLH) vs usual care for people with COPD: the Singing for Health, Improving Experiences of Lung Disease (SHIELD) TrialThorax 2022;77:A53.

    BACKGROUND

  • Philip KEJ, Buttery SC, Bowen S, Lewis A, Jeffery E, Alghamdi SM, Williams P, Alasmari AM, Alsulayyim AS, Orton CM, Conway F, Chan L, Vijayakumar B, Tana A, Tonkin J, Perkins A, Garner JL, Srikanthan K, Sadaka A, Pavitt MJ, Banya W, Lound A, Elkin S, Polkey MI, Man WD, Lewis K, Cave P, Fancourt D, Hopkinson NS. Singing for lung health in COPD: a multicentre randomised controlled trial of online delivery. BMJ Open Respir Res. 2024 May 2;11(1):e002365. doi: 10.1136/bmjresp-2024-002365. PMID: 38697677; PMCID: PMC11086531.

    BACKGROUND

  • Philip KE, Lewis A, Jeffery E, Buttery S, Cave P, Cristiano D, Lound A, Taylor K, Man WD, Fancourt D, Polkey MI, Hopkinson NS. Moving singing for lung health online in response to COVID-19: experience from a randomised controlled trial. BMJ Open Respir Res. 2020 Nov;7(1):e000737. doi: 10.1136/bmjresp-2020-000737.

    PMID: 33239406BACKGROUND

  • Warran K, Fancourt D, Wiseman T. How does the process of group singing impact on people affected by cancer? A grounded theory study. BMJ Open. 2019 Jan 7;9(1):e023261. doi: 10.1136/bmjopen-2018-023261. PMID: 30617100; PMCID: PMC6326295.

    BACKGROUND

  • Kaasgaard M, Rasmussen DB, Lokke A, Vuust P, Hilberg O, Bodtger U. Physiological changes related to 10 weeks of singing for lung health in patients with COPD. BMJ Open Respir Res. 2022 May;9(1):e001206. doi: 10.1136/bmjresp-2022-001206.

    PMID: 35545297BACKGROUND

  • Lewis A, Thomas J. COPD and Singing for Lung Health: A Patient and Clinician Perspective. Pulm Ther. 2018 Dec;4(2):121-124. doi: 10.1007/s41030-018-0063-9. Epub 2018 Sep 7. PMID: 32026394; PMCID: PMC6967078

    BACKGROUND

  • Goodridge D, Nicol JJ, Horvey KJ, et al. Therapeutic Singing as an Adjunct for Pulmonary Rehabilitation Participants With COPD: Outcomes of a Feasibility Study. Music and Medicine. 2013; 5: 169-176. DOI:10.1177/1943862113493012

    BACKGROUND

  • Philip KE, Lewis A, Buttery SC, McCabe C, Manivannan B, Fancourt D, Orton CM, Polkey MI, Hopkinson NS. Physiological demands of singing for lung health compared with treadmill walking. BMJ Open Respir Res. 2021 May;8(1):e000959. doi: 10.1136/bmjresp-2021-000959.

    PMID: 34045239BACKGROUND

  • McNamara RJ, Epsley C, Coren E, McKeough ZJ. Singing for adults with chronic obstructive pulmonary disease (COPD). Cochrane Database Syst Rev. 2017 Dec 19;12(12):CD012296. doi: 10.1002/14651858.CD012296.pub2. PMID: 29253921; PMCID: PMC5835013.

    BACKGROUND

  • Skingley A, Clift S, Hurley S, Price S, Stephens L. Community singing groups for people with chronic obstructive pulmonary disease: participant perspectives. Perspect Public Health. 2018 Jan;138(1):66-75. doi: 10.1177/1757913917740930. Epub 2017 Nov 21.

    PMID: 29160737BACKGROUND

  • Bonilha AG, Onofre F, Vieira ML, Prado MY, Martinez JA. Effects of singing classes on pulmonary function and quality of life of COPD patients. Int J Chron Obstruct Pulmon Dis. 2009;4:1-8. Epub 2009 Apr 15.

    PMID: 19436683BACKGROUND

  • Lord VM, Cave P, Hume VJ, Flude EJ, Evans A, Kelly JL, Polkey MI, Hopkinson NS. Singing teaching as a therapy for chronic respiratory disease--a randomised controlled trial and qualitative evaluation. BMC Pulm Med. 2010 Aug 3;10:41. doi: 10.1186/1471-2466-10-41.

    PMID: 20682030BACKGROUND

  • Lord VM, Hume VJ, Kelly JL, Cave P, Silver J, Waldman M, White C, Smith C, Tanner R, Sanchez M, Man WD, Polkey MI, Hopkinson NS. Singing classes for chronic obstructive pulmonary disease: a randomized controlled trial. BMC Pulm Med. 2012 Nov 13;12:69. doi: 10.1186/1471-2466-12-69.

    PMID: 23145504BACKGROUND

  • Lewis A, Cave P, Hopkinson NS. Singing for Lung Health: a qualitative assessment of a British Lung Foundation programme for group leaders. BMJ Open Resp Res. 2017; 4: e000216. DOI: 10.1136/bmjresp-2017-000216

    BACKGROUND

  • Liu H, Song M, Zhai ZH, Shi RJ, Zhou XL. Group singing improves depression and life quality in patients with stable COPD: a randomized community-based trial in China. Qual Life Res. 2019 Mar;28(3):725-735. doi: 10.1007/s11136-018-2063-5. Epub 2019 Jan 5. PMID: 30612266; PMCID: PMC6394522

    BACKGROUND

  • Heydon R, Fancourt D, Cohen AJ. Heydon, R., Fancourt, D., & J. Cohen, A. The Routledge Companion to Interdisciplinary Studies in Singing (1st ed.). 2020. Volume III: Wellbeing. PART I Singing and Health. Chapter 7, pp. 86-97. Routledge." Routledge; 2020. DOI: 10.4324/9781315162546.

    BACKGROUND

  • Lewis A, Philip KEJ, Lound A, Cave P, Russell J, Hopkinson NS. The physiology of singing and implications for 'Singing for Lung Health' as a therapy for individuals with chronic obstructive pulmonary disease. BMJ Open Respir Res. 2021 Nov;8(1):e000996. doi: 10.1136/bmjresp-2021-000996.

    PMID: 34764199BACKGROUND

  • Kaasgaard M, Rasmussen DB, Andreasson KH, Hilberg O, Løkke A, Vuust P, Bodtger U. Use of Singing for Lung Health as an alternative training modality within pulmonary rehabilitation for COPD: a randomised controlled trial. Eur Respir J. 2022 May 19;59(5):2101142. doi: 10.1183/13993003.01142-2021. PMID: 34625480; PMCID: PMC9117735.

    BACKGROUND

  • Lewis A, Cave P, Stern M, et al. Singing for Lung Health-a systematic review of the literature and consensus statement. npj Prim Care Resp Med. 2016; 26: 16080. DOI: npjpcrm201680.

    BACKGROUND

  • Lewis A, Cave P, Hopkinson N. Singing for Lung Health: service evaluation of the British Lung Foundation programme. Perspect Public Health. 2018; 138: 215-222. DOI: 10.1177/1757913918774079.

    BACKGROUND

  • Goldenberg RB. Singing Lessons for Respiratory Health: A Literature Review. 2018 Jan;32(1). Journal of Voice. 2017; 32: 85-94. DOI: S0892199716304428

    BACKGROUND

  • Poghosyan H, Sheldon LK, Leveille SG, et al. Health-related quality of life after surgical treatment in patients with non-small cell lung cancer: A systematic review. Lung Cancer 2013; 81: 11-26. DOI: S0169500213001189.

    BACKGROUND

  • Kaasgaard M, Andersen IC, Rasmussen DB, et al. Heterogeneity in Danish lung choirs and their singing leaders: delivery, approach, and experiences: a survey-based study. BMJ Open. 2020; 10: e041700. ADOI: 10.1136/bmjopen-2020-041700

    BACKGROUND

  • Bendixen M, Jorgensen OD, Kronborg C, Andersen C, Licht PB. Postoperative pain and quality of life after lobectomy via video-assisted thoracoscopic surgery or anterolateral thoracotomy for early stage lung cancer: a randomised controlled trial. Lancet Oncol. 2016 Jun;17(6):836-844. doi: 10.1016/S1470-2045(16)00173-X. Epub 2016 May 6.

    PMID: 27160473BACKGROUND

  • Aaronson NK, Ahmedzai S, Bergman B, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: A Quality-of-Life Instrument for Use in International Clinical Trials in Oncology. JNCI Journal of the National Cancer Institute. 1993; 85: 365-376. DOI: 10.1093/jnci/85.5.365

    BACKGROUND

  • Kaasgaard M, Bodtger U, Løkke A, et al. Attendance rate and perceived relevance related to type, content, and delivery of current rehabilitation programmes after surgical resection for non-small cell lung cancer. Front Rehabil Sci. 2024. 5: 1447767.DOI: 10.3389/fresc.2024.1447767/full.

    BACKGROUND

  • Edbrooke L, Davies TW, Granger CL, et al. Development of a clinical core outcome set to evaluate lung cancer rehabilitation. ERJ Open Res. 2025. 00058-02025. DOI: 10.1183/23120541.00058-2025

    BACKGROUND

  • Cavalheri V, Burtin C, Formico VR, et al. Exercise training undertaken by people within 12 months of lung resection for non-small cell lung cancer. Cochrane Lung Cancer Group, ed. Cochrane Database of Systematic Reviews. 2019. DOI: 10.1002/14651858.CD009955.pub3.

    BACKGROUND

  • Holland AE, Cox NS, Houchen-Wolloff L, et al. Defining Modern Pulmonary Rehabilitation. An Official American Thoracic Society Workshop Report. Annals ATS 2021; 18: e12-e29. DOI: 10.1513/AnnalsATS.202102-146ST

    BACKGROUND

  • Rochester CL, Vogiatzis I, Holland AE, et al. An Official American Thoracic Society/European Respiratory Society Policy Statement: Enhancing Implementation, Use, and Delivery of Pulmonary Rehabilitation. Am J Respir Crit Care Med. 1373-1386. DOI: 10.1164/rccm.201510-1966ST.

    BACKGROUND

  • Borg M, Løkke A, Rasmussen TR. Symptoms and lung function follow-up after lung cancer resection. Dan Med J. 2021 Sep 15;68(10):A02210115. PMID: 34558410.

    BACKGROUND

  • Shannon VR. Role of pulmonary rehabilitation in the management of patients with lung cancer: Current Opinion in Pulmonary Medicine. 2010. 16: 334-339. DOI: 00063198-201007000-00008.

    BACKGROUND

  • Jakobsen E, Rasmussen TR, Green A. Mortality and survival of lung cancer in Denmark: Results from the Danish Lung Cancer Group 2000-2012. Acta Oncol. 2016 Jun;55 Suppl 2:2-9. doi: 10.3109/0284186X.2016.1150608. Epub 2016 Apr 8.

    PMID: 27056247BACKGROUND

  • Sommer M, Staerkind M, Christensen J, et al. Effect of postsurgical rehabilitation programmes in patients operated for lung cancer: A systematic review and meta-analysis. J Rehabil Med. 2018; 50: 236-245. DOI:10.2340/16501977-2292

    BACKGROUND

  • Gibson GJ, Loddenkemper R, Sibille Y, et al. The European Lung White Book: Respiratory Health and Disease in Europe. European Respiratory Society; 2013. URL: https://books.google.dk/books?id=-C_fnQEACAAJ

    BACKGROUND

  • Gouliaev A, Hilberg O, Christensen NL, et al. Comorbidity among Danish lung cancer patients before and after initial cancer diagnosis. European Clinical Respiratory Journal. 2021. DOI: 10.1080/20018525.2020.1861579

    BACKGROUND

Related Links

MeSH Terms

Conditions

Carcinoma, Non-Small-Cell LungPulmonary Disease, Chronic ObstructiveLung Neoplasms

Interventions

Singing

Condition Hierarchy (Ancestors)

Carcinoma, BronchogenicBronchial NeoplasmsRespiratory Tract NeoplasmsThoracic NeoplasmsNeoplasms by SiteNeoplasmsLung DiseasesRespiratory Tract DiseasesLung Diseases, ObstructiveChronic DiseaseDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

PhonationRespiratory Physiological PhenomenaCirculatory and Respiratory Physiological Phenomena

Central Study Contacts

Mette Kaasgaard, PhD

CONTACT

4528940238mkaasgaard@health.sdu.dk

Uffe Bødtger, PhD

CONTACT

4526791426ubt@regionsjaelland.dk

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
TRIPLE
Who Masked
CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
SUPPORTIVE CARE
Intervention Model
CROSSOVER
Model Details: We will conduct a randomised controlled trial in patients with persistent symptoms 6-18 months after NSCLC surgery, i.e., after completion of any municipal rehabilitation offer shortly after surgery. Moreover, we will conduct an exploratory study in a sub-group of participants with additional advanced assessments of the physiological adaptations to singing. Participants will be randomised 2:1 in blocks of five to either Group 1, receiving 10 weeks' online singing or Group 2, receiving 10 weeks' usual care followed by - to enhance willingness to participate - 10 weeks' online singing.
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor, PhD

Study Record Dates

First Submitted

January 20, 2026

First Posted

March 10, 2026

Study Start

March 1, 2026

Primary Completion (Estimated)

April 1, 2027

Study Completion (Estimated)

October 1, 2027

Last Updated

April 2, 2026

Record last verified: 2026-03

Data Sharing

IPD Sharing
Will not share

Anonymised datasets will be shared upon reasonable request.

Locations

DK(5)