Postprandial Triglyceride Concentrations Across Menstrual Cycle Phases

NCT07459465 | Recruiting

• 1 other identifier: H-06-18-837-2026
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to investigate the effect of menstrual cycle phases on postprandial triglyceride concentrations in healthy young female adults. The main question it aims to answer is: do postprandial triglyceride concentrations differ between the follicular and luteal phases of the menstrual cycle? Participants will: visit the laboratory for a preliminary screening session to assess eligibility, and undergo two experimental sessions consisting of six hours of seated rest following the consumption of a high-fat meal (one session conducted in the early follicular phase, and one session conducted in the mid-luteal phase of the menstrual cycle).

Conditions

Healthy Adult Females

Keywords

Triglyceride; Postprandial Lipemia; High-Fat Meal; Menstrual Cycle

Outcome Measures

Primary Outcomes (7)

• Change from baseline in plasma total triglyceride concentrations

  Plasma total triglyceride concentrations will be measured via colorimetric assays from venous blood samples collected upon arrival at the laboratory (baseline) and during the exposure (i.e., 0 or baseline, 30, 60, 90,120, 180, 240, 300, and 360 minutes).

  6 hours

• Change from baseline in plasma buoyant triglyceride concentrations

  Plasma buoyant triglyceride concentrations will be measured via colorimetric assays from venous blood samples collected upon arrival at the laboratory (baseline) and during the exposure (i.e., 0 or baseline, 30, 60, 90,120, 180, 240, 300, and 360 minutes).

  6 hours

• Change from baseline in plasma denser triglyceride concentrations

  Plasma denser triglyceride concentrations will be measured via colorimetric assays from venous blood samples collected upon arrival at the laboratory (baseline) and during the exposure (i.e., 0 or baseline, 30, 60, 90,120, 180, 240, 300, and 360 minutes).

  6 hours

• Change from baseline in plasma non-esterified fatty acid concentrations

  Plasma non-esterified fatty acid concentrations will be measured via colorimetric assays from venous blood samples collected upon arrival at the laboratory (baseline) and during the exposure (i.e., 0 or baseline, 30, 60, 90,120, 180, 240, 300, and 360 minutes).

  6 hours

• Change from baseline in plasma insulin concentrations

  Plasma insulin concentrations will be measured via colorimetric assays from venous blood samples collected upon arrival at the laboratory (baseline) and during the exposure (i.e., 0 or baseline, 30, 60, 90,120, 180, 240, 300, and 360 minutes).

  6 hours

• Change from baseline in plasma glucose concentrations

  Plasma glucose concentrations will be measured via colorimetric assays from venous blood samples collected upon arrival at the laboratory (baseline) and during the exposure (i.e., 0 or baseline, 30, 60, 90,120, 180, 240, 300, and 360 minutes).

  6 hours

• Change from baseline in plasma β-hydroxybutyrate concentrations

  Plasma β-hydroxybutyrate concentrations will be measured via colorimetric assays from venous blood samples collected upon arrival at the laboratory (baseline) and during the exposure (i.e., 0 or baseline, 60, 120, 180, 240, 300, and 360 minutes).

  6 hours

Secondary Outcomes (11)

• Baseline serum β-estradiol concentrations

  Baseline

• Baseline serum progesterone concentrations

  Baseline

• Fasting resting energy expenditure

  Baseline

• Change from baseline in respiratory exchange ratio

  6 hours

• Change from baseline in desire to eat

  6 hours

Study Arms (2)

Early Follicular Phase

EXPERIMENTAL

Other: Early Follicular Phase

Mid-Luteal Phase

EXPERIMENTAL

Other: Mid-Luteal Phase

Interventions

Early Follicular Phase OTHER

In the early follicular phase of the menstrual cycle, participants will undergo 6 hours of seated rest after the consumption of a high-fat meal representing 33% of estimated daily energy expenditure and consisting of 59% of calories from fat.

Early Follicular Phase

Mid-Luteal Phase OTHER

In the mid-luteal phase of the menstrual cycle, participants will undergo 6 hours of seated rest after the consumption of a high-fat meal representing 33% of estimated daily energy expenditure and consisting of 59% of calories from fat.

Mid-Luteal Phase

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• English or French speaking
• Ability to provide informed consent

You may not qualify if:

• History or evidence of chronic disease
• Current use of hypolipemic medication
• Current use of hormonal contraceptives
• Current use of antidepressants
• Current use of anticoagulants
• Ongoing smoking status
• Experiencing pregnancy, puerperium, or irregular menstrual cycles

Sponsors & Collaborators

• University of Ottawa: lead
• Natural Sciences and Engineering Research Council, Canada: collaborator
• Hopital Montfort: collaborator
• Institut du Savoir Montfort: collaborator

Study Sites (1)

Behavioural and Metabolic Research Unit, School of Human Kinetics, Faculty of Health Sciences, University of Ottawa

Ottawa, Ontario, K1S 5S9, Canada

RECRUITING

Central Study Contacts

Pascal Imbeault, PhD

CONTACT

6135625800 ext 7290; imbeault@uottawa.ca

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 3, 2026
• First Posted: March 9, 2026
• Study Start: March 26, 2026
• Primary Completion (Estimated): August 31, 2026
• Study Completion (Estimated): August 31, 2026
• Last Updated: May 19, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)