Epileptiform Potential of Fully Immersive Virtual Reality

NCT07451093 | Not Yet Recruiting

• 1 other identifier: 02002874
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this interventional study is to determine if the use of virtual reality headsets results in an increased risk of seizure in adolescent and adult individuals with epilepsy. The main question it aims to answer are: \- does use of virtual reality headsets with hand controllers result in a higher risk of seizure compared to use of virtual reality headsets without hand controllers Participants will be asked to wear a virtual reality headset during continuous video EEG recording and EEG with be evaluated during three phases: with display turned off, with display turned on without hand controllers, and with display turned on with hand controllers.

Conditions

Epilepsy; Seizure

Keywords

Epilepsy; Seizure; Virtual Reality; VR; Reflex epilepsy

Outcome Measures

Primary Outcomes (1)

• Change in prevalence of interictal epileptiform discharges

  Interictal epileptiform discharges are counted by two epilepsy trained neurologists. Number of discharges seen are compared between each intervention.

  Three sessions, 15 minutes each

Other Outcomes (1)

• Seizure

  3 trials, 15 minutes each

Study Arms (1)

Virtual Reality Arm

EXPERIMENTAL

Participants wear VR headset during video EEG recording for a total of 3 sessions, each lasting 15 minutes each.

Other: Virtual Reality Headset, display off; Other: Virtual Reality Headset, Display only; Other: Virtual Reality Headset, Display and Hand Control

Interventions

Virtual Reality Headset, display off OTHER

15 minutes of EEG recording with VR headset worn, display turned off. This will act as a baseline for intervention 2 and 3

Virtual Reality Arm

Virtual Reality Headset, Display only OTHER

15 minutes of EEG recording with VR headset worn, display turned on without access to hand controls.

Virtual Reality Arm

Virtual Reality Headset, Display and Hand Control OTHER

15 minutes of EEG recording with VR headset worn, display turned on with access to hand controls

Virtual Reality Arm

Eligibility Criteria

• Age: 13 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• subjects with known or suspected diagnosis of epilepsy with interictal epileptiform discharges seen during current or prior EEG recording
• Age greater than or equal to 13 years

You may not qualify if:

• Age less than 13 years (infants, children)
• Pregnancy
• Incarceration
• Moderate-severe cognitive impairment

Sponsors & Collaborators

• Dartmouth-Hitchcock Medical Center: lead

Study Sites (1)

Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, 03756, United States

Location

MeSH Terms

Conditions

Epilepsy; Seizures; Epilepsy, Reflex

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Jared E Quast, MD

  Dartmouth-Hitchcock Medical Center

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Jared E Quast, MD

CONTACT

6033505104; jared.e.quast@hitchcock.org

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: February 12, 2026
• First Posted: March 5, 2026
• Study Start: June 1, 2026
• Primary Completion (Estimated): June 1, 2027
• Study Completion (Estimated): June 1, 2027
• Last Updated: May 6, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)