Hippocampal Oscillations During Exploration
Human Hippocampal Oscillations During Visuomotor Exploration
2 other identifiers
interventional
56
1 country
1
Brief Summary
The objective of this study is to determine how visuomotor exploration relates to hippocampal activity along its long axis. The study will investigate the neurophysiological mechanisms in the hippocampus during (1) visual exploration in surgical patients using high-resolution iEEG, and (2) ambulatory exploration in patients implanted with RNS devices.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Feb 2026
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 31, 2025
CompletedFirst Posted
Study publicly available on registry
November 4, 2025
CompletedStudy Start
First participant enrolled
February 25, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 8, 2028
ExpectedStudy Completion
Last participant's last visit for all outcomes
October 8, 2028
February 27, 2026
February 1, 2026
2.6 years
October 31, 2025
February 26, 2026
Conditions
Outcome Measures
Primary Outcomes (8)
Hippocampal Theta Power Under High Cognitive Loads
Aims 1 and 2. High cognitive loads defined as visual exploration of a complex scene with goal-driven task.
Study Visit (Day 1)
Hippocampal Theta Power Under Medium Cognitive Loads
Aims 1 and 2. Medium cognitive loads defined as visual exploration of a simpler scene with fewer objects.
Study Visit (Day 1)
Hippocampal Theta Power Under Low Cognitive Loads
Aims 1 and 2. Low cognitive loads defined as visual exploration of moving dots.
Study Visit (Day 1)
Hippocampal Theta Power Under No Cognitive Loads
Aims 1 and 2. Low cognitive loads defined as staring at a blank field of view or REM sleep.
Study Visit (Day 1)
Coherence Time-Locked to the Saccade Under High Cognitive Loads
Aims 1 and 2. High cognitive loads defined as visual exploration of a complex scene with goal-driven task.
Study Visit (Day 1)
Coherence Time-Locked to the Saccade Under Medium Cognitive Loads
Aims 1 and 2. Medium cognitive loads defined as visual exploration of a simpler scene with fewer objects.
Study Visit (Day 1)
Coherence Time-Locked to the Saccade Under Low Cognitive Loads
Aims 1 and 2. Low cognitive loads defined as staring at a blank field of view or REM sleep.
Study Visit (Day 1)
Coherence Time-Locked to the Saccade Under No Cognitive Loads
Aims 1 and 2. Low cognitive loads defined as staring at a blank field of view or REM sleep.
Study Visit (Day 1)
Study Arms (3)
Epilepsy Surgery Patients
EXPERIMENTALAim 1: Participants will be presented with between 10-15 unique immersive virtual environments (depending on patient tolerance) for patients to explore using VR glasses. Control tasks will be run to account for eye movements during non-navigation. For recording eye movements in darkness during REM sleep, as part of a control task, 4 electrodes will be placed above and below both eyes, a standard technique in polysomnographic studies.
Patients with RNS Devices
EXPERIMENTALAim 2: Participants will walk between 4-6 rooms within an office floor. Each office will contain generic objects (office furniture, computers, lighting) and unique objects (artwork, photographs, books, and personal items). As control conditions, subjects will first be asked to walk around and between two empty rooms under different lighting conditions and speeds. Participants will also be asked to participate in all awake saccade control conditions (without a visual cognitive load).
Healthy Control Participants
EXPERIMENTALAim 2: Participants will walk between 4-6 rooms within an office floor. Each office will contain generic objects (office furniture, computers, lighting) and unique objects (artwork, photographs, books, and personal items). As control conditions, subjects will first be asked to walk around and between two empty rooms under different lighting conditions and speeds. Participants will also be asked to participate in all awake saccade control conditions (without a visual cognitive load).
Interventions
Series of cognitive tasks completed during a study visit.
Cognitive testing while admitted to the epilepsy monitoring unit (number of sessions will vary depending on patient availability and stamina).
Eligibility Criteria
You may qualify if:
- All subjects:
- Adults (18-70 years)
- Able to provide informed consent
- Implanted hippocampal depth electrodes for Stage 1 epilepsy surgery
- IQ=\>80\*
- Implanted RNS device with at least one hippocampal depth electrode
- At least 5 months post-implantation to avoid the post-implant effect
- Have a relatively low number of seizures, defined as =\<1 debilitating seizure per week
- Able to walk and wear research equipment without assistance
- IQ\>=80
You may not qualify if:
- RNS patients, Aim 2:
- Any generalized tonic-clonic seizure(s) within the last year
- All subjects:
- Legally blind
- Smoking tobacco, marijuana, recreational drugs or alcohol use within 1 week of cognitive testing
- Unable to give informed consent
- Pregnancy
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
NYU Langone Health
New York, New York, 10016, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Anli Liu, MD, MA
NYU Langone Health
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
October 31, 2025
First Posted
November 4, 2025
Study Start
February 25, 2026
Primary Completion (Estimated)
October 8, 2028
Study Completion (Estimated)
October 8, 2028
Last Updated
February 27, 2026
Record last verified: 2026-02
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, SAP
- Time Frame
- Beginning 9 months and ending 36 months following article publication or as required by a condition of awards and agreements supporting the research.
- Access Criteria
- Requests should be directed to anli.liu@nyulangone.org. To gain access, data requestors will need to sign a data access agreement. This instance of data sharing will also require separate IRB review as well as review from NYU Langone's DSSB.
The study will upload data into openneuro.org or comparable neuroscience data sharing platform, with data uploaded on a basis as specified by the conditions of awards supporting this research.