MRI Assessment of Body Composition in Bariatric Surgery

NCT07711925 | Enrolling By Invitation

• 1 other identifier: 53/2025
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to evaluate changes in adipose tissue and skeletal muscle distribution using magnetic resonance imaging (MRI) in adults with obesity undergoing bariatric surgery. The study also aims to investigate the relationship between MRI-derived body composition parameters and metabolic outcomes following surgical treatment of obesity. The main questions it aims to answer are: How does bariatric surgery affect the distribution of visceral, subcutaneous, hepatic, perirenal adipose tissue and skeletal muscle over 12 months? Are changes in MRI-derived body composition associated with improvements in metabolic parameters after bariatric surgery? Participants will: undergo MRI examinations before bariatric surgery and at 1, 6, and 12 months after surgery; undergo routine clinical and metabolic assessments during standard postoperative follow-up; have MRI-derived body composition measurements correlated with metabolic outcomes over the 12-month follow-up period.

Conditions

Obesity (BMI>30)

Keywords

obesory; bmi; body composition; sleeve gastrectomy; bariatric surgery; MRI

Outcome Measures

Primary Outcomes (1)

• Change in abdominal adipose tissue distribution assessed by magnetic resonance imaging (MRI)

  Change in visceral and subcutaneous abdominal adipose tissue volume measured by MRI and its association with metabolic outcomes following bariatric surgery.

  Baseline and 3 and 12 months after bariatric surgery

Secondary Outcomes (5)

• Change in skeletal muscle volume

  Baseline, 3 months, and 12 months after bariatric surgery

• Change in hepatic fat content

  Baseline, 3 months, and 12 months after bariatric surgery

• Change in glycated hemoglobin (HbA1c)

  Baseline, 3 months, and 12 months after bariatric surgery.

• Change in serum triglyceride concentration

  Baseline, 3 months, and 12 months after bariatric surgery.

• Change in lipoprotein(a) concentration

  Baseline, 3 months, and 12 months after bariatric surgery.

Study Arms (1)

Adults Undergoing Bariatric Surgery

OTHER

Diagnostic Test: MRI

Interventions

MRI DIAGNOSTIC_TEST

Magnetic resonance imaging (MRI) will be used to assess body composition before bariatric surgery and at 1, 3, and 12 months after surgery. MRI examinations will quantify visceral and subcutaneous adipose tissue, skeletal muscle volume, intramuscular fat, hepatic fat, and perirenal fat. Imaging findings will be analyzed longitudinally and correlated with routine clinical and metabolic parameters to evaluate changes in body composition following bariatric surgery.

Adults Undergoing Bariatric Surgery

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 18 years or older
• BMI \>= 30 kg/m2
• qualified to undergo bariatric surgery
• Ability to provide written informed consent
• Willingness to undergo magnetic resonance imaging before surgery and 3, and 12 months after surgery

You may not qualify if:

• Previous bariatric surgery
• Presence of ferromagnetic implants or other contraindications to magnetic resonance imaging
• Previous plastic or surgical procedures affecting the body region assessed by MRI, except cholecystectomy, appendectomy, or inguinal hernia repair
• Chronic kidney disease stage 4 or higher
• Pregnancy
• Claustrophobia preventing MRI examination
• Inability or unwillingness to provide informed consent

Sponsors & Collaborators

• University of Warmia and Mazury in Olsztyn: lead

Study Sites (1)

University of Warmia and Mazury

Olsztyn, Warminsko-mazusrkie, 10-045, Poland

Location

Related Publications (4)

• Bai J, Wang S, Pan H, Shi Z, Zhao M, Yue X, Yang K, Zhang X, Wang W, Liu C, Zhang T. Correlation analysis of dynamic changes of abdominal fat during rapid weight loss after bariatric surgery: A prospective magnetic resonance imaging study. Eur J Radiol. 2024 Sep;178:111630. doi: 10.1016/j.ejrad.2024.111630. Epub 2024 Jul 15.

  PMID: 39024662 BACKGROUND

• Shang-Guan ZX, Lin GT, Liu ZY, Zhong Q, Huang Q, Li P, Xie JW, Wang JB, Lu J, Chen QY, Cao LL, Lin M, Zheng HL, Zheng CH, Lin JX, Huang CM. Effect of Sarcopenic Obesity on Weight Loss Outcomes and Quality of Life after Laparoscopic Sleeve Gastrectomy: A Retrospective Cohort Study. Obes Surg. 2024 May;34(5):1479-1490. doi: 10.1007/s11695-024-07146-z. Epub 2024 Mar 15.

  PMID: 38489003 BACKGROUND

• Emamat H, Jamshidi A, Farhadi A, Ghalandari H, Ghasemi M, Tangestani H. The association between the visceral to subcutaneous abdominal fat ratio and the risk of cardiovascular diseases: a systematic review. BMC Public Health. 2024 Jul 9;24(1):1827. doi: 10.1186/s12889-024-19358-0.

  PMID: 38982435 BACKGROUND

• Neeland IJ, Ross R, Despres JP, Matsuzawa Y, Yamashita S, Shai I, Seidell J, Magni P, Santos RD, Arsenault B, Cuevas A, Hu FB, Griffin B, Zambon A, Barter P, Fruchart JC, Eckel RH; International Atherosclerosis Society; International Chair on Cardiometabolic Risk Working Group on Visceral Obesity. Visceral and ectopic fat, atherosclerosis, and cardiometabolic disease: a position statement. Lancet Diabetes Endocrinol. 2019 Sep;7(9):715-725. doi: 10.1016/S2213-8587(19)30084-1. Epub 2019 Jul 10.

  PMID: 31301983 BACKGROUND

MeSH Terms

Conditions

Obesity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof. of UWM, MD, PhD

Model Details: This is a prospective longitudinal cohort study in which adults undergoing bariatric surgery will be followed for 12 months. Participants will undergo serial magnetic resonance imaging (MRI) examinations before surgery and during postoperative follow-up to evaluate changes in adipose tissue distribution and skeletal muscle composition and their association with metabolic outcomes.

Study Record Dates

• First Submitted: July 13, 2026
• First Posted: July 17, 2026
• Study Start: January 22, 2026
• Primary Completion (Estimated): January 22, 2027
• Study Completion (Estimated): May 1, 2027
• Last Updated: July 17, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

PL (1)