NCT07448064

Brief Summary

Purpose: This study aims to better understand how force is produced during a vertical jump in individuals approximately six months after anterior cruciate ligament reconstruction compared with healthy individuals. After this type of knee surgery, many patients recover well clinically but may still present strength differences between the operated and non-operated leg. These differences are not always visible during routine clinical testing but may influence performance and potentially increase the risk of reinjury. By analyzing how force is generated during a standardized countermovement jump, this study seeks to identify whether biomechanical alterations persist at this stage of recovery and to improve decision-making related to rehabilitation and return to sport. Study Design: This is an observational comparative study. Participants who have undergone anterior cruciate ligament reconstruction using a hamstring tendon graft will be assessed between five and seven months after surgery. Their results will be compared with those of healthy recreationally active individuals without a history of recent knee injury. No experimental treatment or modification of rehabilitation will be introduced as part of this study. Procedures: Participants will complete a brief standardized warm-up followed by three maximal vertical countermovement jumps performed on a force platform. During the test, participants will keep their hands on their hips and will be instructed to jump as quickly and as high as possible. The force platform measures ground reaction forces from each leg separately, allowing detailed analysis of the lowering phase (when the body bends before jumping) and the push-off phase (when the body propels upward). The entire testing session lasts only a few minutes and reflects movements commonly used in rehabilitation and sports settings. Measurements: The primary measurements include jump height and the mean force produced by each leg during both the eccentric (lowering) and concentric (push-off) phases of the jump. The study will also calculate limb symmetry indices to determine the degree of difference between the operated and non-operated legs. These measurements provide objective information about neuromuscular recovery and functional performance after surgery. Risks: The procedures involve physical activity comparable to exercises already performed during standard rehabilitation. The risks are minimal and similar to those encountered during routine physical training. Participants may stop the test at any time if they experience discomfort. Potential Benefits: Participants may not receive direct personal benefit from taking part in the study. However, the results may contribute to improving rehabilitation strategies, refining criteria used for return-to-sport decisions, and enhancing long-term functional outcomes after anterior cruciate ligament reconstruction. A better understanding of persistent biomechanical alterations may ultimately help reduce the risk of secondary injury and optimize recovery pathways.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
100

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Mar 2022

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 2, 2022

Completed
3.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 31, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 31, 2025

Completed
11 months until next milestone

First Submitted

Initial submission to the registry

February 25, 2026

Completed
7 days until next milestone

First Posted

Study publicly available on registry

March 4, 2026

Completed
Last Updated

March 4, 2026

Status Verified

March 1, 2022

Enrollment Period

3.1 years

First QC Date

February 25, 2026

Last Update Submit

February 25, 2026

Conditions

Keywords

Anterior Cruciate Ligament ReconstructionCountermovement JumpKnee BiomechanicsReturn to Sport

Outcome Measures

Primary Outcomes (1)

  • Eccentric Mean Force

    3 and 6 months

Secondary Outcomes (3)

  • Concentric Mean Force

    3 and 6 months

  • Jump Height

    3 and 6 months

  • Quadriceps and Hamstring Peak Torque

    3 and 6 months

Study Arms (2)

ACLR

Individuals aged 18-40 years who underwent primary anterior cruciate ligament reconstruction using a hamstring tendon graft and are assessed between 5 and 7 months after surgery. Participants must have completed standard rehabilitation and be cleared for functional testing at the time of evaluation.

Other: Countermovement Jump Force Platform AssessmentOther: Isokinetic Test

Healthy

Recreationally active individuals aged 18-40 years with no history of anterior cruciate ligament injury, no lower limb surgery, and no musculoskeletal injury affecting the lower extremities within the past 12 months. Participants must be physically active and free from current knee pain at the time of testing.

Other: Countermovement Jump Force Platform AssessmentOther: Isokinetic Test

Interventions

Participants perform three maximal countermovement jumps on a calibrated force platform after a standardized warm-up. Hands are kept on the hips during testing. The platform records ground reaction forces from each limb separately during the eccentric (lowering) and concentric (push-off) phases of the jump. Jump height and limb symmetry indices are calculated. This procedure is used for biomechanical and functional assessment only and does not modify standard rehabilitation.

ACLRHealthy

isokinetic dynamometry is performed to assess concentric quadriceps and hamstring strength at standardized angular velocities. Peak torque values and limb symmetry indices are calculated for quadriceps and hamstring

ACLRHealthy

Eligibility Criteria

Age18 Years - 40 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)
Sampling MethodProbability Sample
Study Population

The study population includes adults aged 18 to 40 years. The post-anterior cruciate ligament reconstruction cohort consists of individuals who underwent primary reconstruction using a hamstring tendon autograft and are evaluated between 5 and 7 months after surgery, following completion of standard rehabilitation and medical clearance for functional testing. The healthy control cohort includes recreationally active individuals with no history of anterior cruciate ligament injury, no prior lower limb surgery, and no lower extremity injury within the past 12 months. All participants must be able to perform maximal effort jumping and isokinetic strength testing.

You may qualify if:

  • Post-Anterior Cruciate Ligament Reconstruction Cohort:
  • Age between 18 and 40 years
  • Primary anterior cruciate ligament reconstruction using a hamstring tendon autograft
  • Assessment performed between 5 and 7 months post-surgery
  • Completion of standard postoperative rehabilitation
  • Medical clearance for functional testing
  • Ability to perform maximal effort jumping and strength testing
  • Healthy Control Cohort:
  • Age between 18 and 40 years
  • Recreationally active (minimum two sessions of physical activity per week)
  • No history of anterior cruciate ligament injury
  • No lower limb surgery
  • No lower extremity injury within the past 12 months
  • No current knee pain or functional limitation

You may not qualify if:

  • Previous anterior cruciate ligament reconstruction on either knee (except the index surgery for the ACL group)
  • Concomitant ligament reconstruction (e.g., posterior cruciate ligament, medial collateral ligament, lateral collateral ligament)
  • Symptomatic meniscal repair limiting full participation in testing
  • Neurological disorders affecting lower limb function
  • Inflammatory joint disease
  • Pregnancy
  • Inability to perform maximal effort testing

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Haute Ecole ARC

Delémont, Switzerland

Location

Related Publications (3)

  • Ricupito, R., Bravi, M., Santacaterina, F., Campardo, G., Guarise, R., Castellucci, R., Alaoui, I. B., & Forelli, F. (2025). Biomechanical Alterations in the Unweight Phase of the Single-Leg Countermovement Jump After ACL Reconstruction. Journal of functional morphology and kinesiology, 10(3), 296. https://doi.org/10.3390/jfmk10030296

    RESULT
  • Forelli, F., Moiroux-Sahraoui, A., Mazeas, J., Ly, W., Bialy, M., Douryang, M., Hewett, T. E., & De Fontenay, B. P. (2025). Evaluation of eccentric and concentric force during vertical jump after anterior cruciate ligament reconstruction: a comparative study. BMC sports science, medicine & rehabilitation, 17(1), 259. https://doi.org/10.1186/s13102-025-01301-4

    RESULT
  • Forelli, F., Moiroux-Sahraoui, A., Nekhouf, B., Bouzekraoui Alaoui, I., Vandebrouck, A., Duffiet, P., Ratte, L., Bialy, M., Bjerregaard, A., Mazeas, J., Douryang, M., & Rambaud, A. (2025). Is Deceleration the Key Element in Vertical Jump Performance to Return to Sport After Anterior Cruciate Ligament Reconstruction With Hamstring Graft? A Preliminary Study. International journal of sports physical therapy, 20(9), 1321-1329. https://doi.org/10.26603/001c.142878

    RESULT

MeSH Terms

Conditions

Anterior Cruciate Ligament Injuries

Condition Hierarchy (Ancestors)

Knee InjuriesLeg InjuriesWounds and Injuries

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
PhD

Study Record Dates

First Submitted

February 25, 2026

First Posted

March 4, 2026

Study Start

March 2, 2022

Primary Completion

March 31, 2025

Study Completion

March 31, 2025

Last Updated

March 4, 2026

Record last verified: 2022-03

Data Sharing

IPD Sharing
Will not share

Locations