Combined Compared to Sequential Cognitive and Physical Training in Anterior Cruciate Ligament Reconstructed Individuals

NCT06845150 | Terminated DMC

• 1 other identifier: DUACL
• Study Type: interventional
• Target: 2
• Locations: 1 country
• Sites: 2

Brief Summary

The goal of this clinical trial is to investigate changes in cognitive and physical performance after 10 weeks of dual or single task training in anterior cruciate ligament (ACL) reconstructed individuals. The main questions it aims to answer are:

• Does cognitive performance in ACL reconstructed individuals change after multiple training sessions incorporating single versus dual-task?
• Does physical performance and intrinsic motivation for training change over the course of 10 weeks when performing single versus dual-task training sessions?
• What movement patterns do ACL reconstructed individuals show during a dual-task training in an immersive environment? Researchers will compare a combined dual-task training (combined physical and cognitive training) to a single task training (physical and cognitive training separately) to see if there are changes on cognitive performance depending on the training type. Participants will:
• Perform dual-task or single task training twice per week for 10 weeks
• Visit the clinic before and after the training period for tests
• Visit the movement laboratory once for analysis of movement patterns

Conditions

Anterior Cruciate Ligament Reconstruction Rehabilitation

Keywords

motor-cognitive training; dual-task training; anterior cruciate ligament injury; return to competition

Outcome Measures

Primary Outcomes (2)

• Interference

  Measured by the difference in reaction time of congruent and incongruent stimuli of the Flanker task.

  Baseline, after 5 weeks of training, after 10 weeks of training

• Response inhibition

  Measured by the accuracy of Go/No-Go-stimuli

  Baseline, after 5 weeks of training, after 10 weeks of training

Secondary Outcomes (6)

• Jumping performance - contact time

  Baseline and after 10 weeks of training

• Jumping performance - peak force

  Baseline and after 10 weeks of training

• Strength

  Baseline and after 10 weeks of training

• Intrinsic motivation

  At the end of each training session (2x/week for 10 weeks)

• Kinematics and kinetics of the lower extremities

  During dual-task training in an immersive environment

Other Outcomes (5)

• Kujala

  Baseline and after 10 weeks of training

• ACL-Return to Sport after Injury Scale

  Baseline and after 10 weeks of training

• Tegner Activity Scale

  Baseline and after 10 weeks of training

Study Arms (2)

Dual-task training

EXPERIMENTAL

Other: Dual-task training

Single task training

ACTIVE COMPARATOR

Other: Single task training

Interventions

Dual-task training OTHER

Combined simultaneous physical and cognitive training in an immersive environment

Dual-task training

Single task training OTHER

Sequential cognitive and then physical training

Single task training

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• years old
• At least 6 months after ACL injury
• Surgically reconstructed ACL
• At least 2 hours of sports participation before the injury
• Written consent of the attending surgeon to perform intensified training methods including one-legged jumps at 6 months after surgery after the first visit
• Ability to give informed consent as documented by signature
• Ability to understand instructions in German or English
• BMI \< 28 kg/m\^2
• Availability to take part in at least 70% of all training sessions

You may not qualify if:

• Surgery on the contralateral leg during the last 12 months
• Acute or chronic musculoskeletal, neurological, or cardiopulmonary disorders
• Unadjusted vision problems
• Concussion during the last 6 months
• Pregnancy
• Breastfeeding
• Amputation
• Inflammatory pain or swelling during exercising

Sponsors & Collaborators

• Michelle C. Haas: lead
• Kantonsspital Winterthur KSW: collaborator
• ZHAW DIZH Fellowship Program: collaborator

Study Sites (2)

KSW Kantonsspital Winterthur

Winterthur, 8000, Switzerland

Location

ZHAW Zurich University of Applied Sciences

Winterthur, 8000, Switzerland

Location

MeSH Terms

Conditions

Anterior Cruciate Ligament Injuries

Condition Hierarchy (Ancestors)

Knee Injuries; Leg Injuries; Wounds and Injuries

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Masking Details: concealed allocation of group
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Research Associate

Study Record Dates

• First Submitted: February 13, 2025
• First Posted: February 25, 2025
• Study Start: June 5, 2025
• Primary Completion: June 12, 2025
• Study Completion: October 8, 2025
• Last Updated: December 8, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will share

Locations

CH (2)