Arthroscopic Anterior Cruciate Ligament Reconstruction by Hamstring Graft With and Without Platelet-Rich Plasma

NCT07269522 | Completed

• 1 other identifier: DR-NAVEED-LGH
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

No local data exists regarding the outcomes of anterior cruciate ligament reconstruction by hamstring graft with and without platelet-rich plasma. This study aimed to compare the functional outcomes of arthroscopic anterior cruciate ligament reconstruction by hamstring graft with and without platelet-rich plasma.

Conditions

Anterior Cruciate Ligament Injury

Outcome Measures

Primary Outcomes (3)

• Anterior Drawer's test

  Number of patients having grade-1 on the Anterior Drawer's test

  12 weeks

• Lachman's test

  Number of patients having grade-1 on the Lysholm knee score

  12 weeks

• Lysholm knee score

  A higher Lysholm knee score was labeled as effectiveness of the treatment.

  12 weeks

Study Arms (2)

ACL reconstruction by hamstring graft with PRP group

EXPERIMENTAL

Patients underwent anterior cruciate ligament reconstruction by hamstring graft along with platelet-rich plasma augmentation applying the standard arthroscopic ACL reconstruction technique.

Procedure: ACL reconstruction by hamstring graft with PRP

ACL reconstruction by hamstring graft group

EXPERIMENTAL

Patients underwent anterior cruciate ligament reconstruction by hamstring graft without platelet-rich plasma augmentation applying the standard arthroscopic ACL reconstruction technique.

Procedure: ACL reconstruction by hamstring graft

Interventions

ACL reconstruction by hamstring graft with PRP PROCEDURE

Patients underwent anterior cruciate ligament reconstruction by hamstring graft along with platelet-rich plasma augmentation applying the standard arthroscopic ACL reconstruction technique.

ACL reconstruction by hamstring graft with PRP group

ACL reconstruction by hamstring graft PROCEDURE

Patients underwent anterior cruciate ligament reconstruction by hamstring graft without platelet-rich plasma augmentation applying the standard arthroscopic ACL reconstruction technique.

ACL reconstruction by hamstring graft group

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Any gender
• Aged 18-40 years
• With clinically and radiologically confirmed arthroscopic evidence of ACL injury

You may not qualify if:

• With comprised bilateral ACL tears
• Lack of fitness due to associated comorbidity
• Fractures of lower limb bones and/or spine/neurovascular injuries
• Injuries to other knee ligaments
• Significant knee joint arthritis
• Local skin infections

Sponsors & Collaborators

• Muhammad Aamir Latif: lead

Study Sites (1)

Lahore General Hospital

Lahore, Punjab Province, 54000, Pakistan

Location

MeSH Terms

Conditions

Anterior Cruciate Ligament Injuries

Condition Hierarchy (Ancestors)

Knee Injuries; Leg Injuries; Wounds and Injuries

Study Officials

• Naveed Ali, FCPS

  Lahore General Hospital, Lahore, Pakistan

  PRINCIPAL INVESTIGATOR

• Muhammad Hanif, FCPS

  Lahore General Hospital, Lahore, Pakistan

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Research Consultant

Study Record Dates

• First Submitted: November 25, 2025
• First Posted: December 8, 2025
• Study Start: January 15, 2022
• Primary Completion: June 30, 2023
• Study Completion: June 30, 2023
• Last Updated: December 8, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)