NCT07444866

Brief Summary

Develop and test a machine learning enabled management of behavioural and psychological symptoms of dementia intervention for dementia caregivers.

Trial Health

63
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
550

participants targeted

Target at P75+ for not_applicable

Timeline
18mo left

Started Jun 2026

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress3%
Jun 2026Nov 2027

First Submitted

Initial submission to the registry

February 25, 2026

Completed
6 days until next milestone

First Posted

Study publicly available on registry

March 3, 2026

Completed
3 months until next milestone

Study Start

First participant enrolled

June 1, 2026

Completed
1.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 30, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 30, 2027

Last Updated

May 18, 2026

Status Verified

May 1, 2026

Enrollment Period

1.5 years

First QC Date

February 25, 2026

Last Update Submit

May 14, 2026

Conditions

Keywords

Hybrid factorial - Sequential Multiple Assignment Randomized Trial, Micro Randomized Trial experimental designmachine learninginterventiondementia caregiver

Outcome Measures

Primary Outcomes (1)

  • Stress

    10-item Perceived Stress Scale; each item will be rated from 0=Never to 4=Very often. Total scores range from 0 to 40.

    Baseline (T0), 6 weeks after baseline assessment (T1), 10 weeks after baseline assessment (T2), 20 weeks after baseline assessment (T3), 32 weeks after baseline assessment (T4)

Secondary Outcomes (12)

  • Depression

    Baseline (T0), 6 weeks after baseline assessment (T1), 10 weeks after baseline assessment (T2), 20 weeks after baseline assessment (T3), 32 weeks after baseline assessment (T4)

  • Sleep Quality

    Baseline (T0), 6 weeks after baseline assessment (T1), 10 weeks after baseline assessment (T2), 20 weeks after baseline assessment (T3), 32 weeks after baseline assessment (T4)

  • Anxiety

    Baseline (T0), 6 weeks after baseline assessment (T1), 10 weeks after baseline assessment (T2), 20 weeks after baseline assessment (T3), 32 weeks after baseline assessment (T4)

  • Physical Health

    Baseline (T0), 32 weeks after baseline assessment (T4)

  • Physical Health

    Baseline (T0), 32 weeks after baseline assessment (T4)

  • +7 more secondary outcomes

Other Outcomes (1)

  • Caregiving

    Baseline (T0), 6 weeks after baseline assessment (T1), 10 weeks after baseline assessment (T2), 20 weeks after baseline assessment (T3), 32 weeks after baseline assessment (T4)

Study Arms (13)

Active control

ACTIVE COMPARATOR

Active control

Behavioral: Active Control

App & Human Coaching + Continue Intervention

EXPERIMENTAL

First-line of coaching: App + Human Coaching Responder

Behavioral: Behavioral: Continue

App & Human Coaching + Increase intensity in human coaching

EXPERIMENTAL

First-line of coaching: App + Human Coaching Non-Responder

Behavioral: Behavioral: Enhance human coaching

App & Human Coaching + Booster

EXPERIMENTAL

First-line of coaching: App + Human Coaching Non-Responder

Behavioral: Behavioral: Booster

App Coaching + Continue Intervention

EXPERIMENTAL

First-line of coaching: App Coaching Responder

Behavioral: Behavioral: Continue

App Coaching + Increase intensity in human coaching

EXPERIMENTAL

First-line of coaching: App Coaching Non-Responder

Behavioral: Behavioral: Enhance human coaching

App Coaching + Booster

EXPERIMENTAL

First-line of coaching: App Coaching Non-Responder

Behavioral: Behavioral: Booster

Human Coaching + Continue Intervention

EXPERIMENTAL

First-line of coaching: Human Coaching Responder

Behavioral: Behavioral: Continue

Human Coaching + Increase intensity in human coaching

EXPERIMENTAL

First-line of coaching: Human Coaching Non-Responder

Behavioral: Behavioral: Enhance human coaching

Human Coaching + Booster

EXPERIMENTAL

First-line of coaching: Human Coaching Non-Responder

Behavioral: Behavioral: Booster

No Coaching + Continue Intervention

EXPERIMENTAL

First-line of coaching: No Coaching Responder

Behavioral: Behavioral: Continue

No Coaching + Increase intensity in human coaching

EXPERIMENTAL

First-line of coaching: No Coaching Non-Responder

Behavioral: Behavioral: Enhance human coaching

No Coaching + Booster

EXPERIMENTAL

First-line of coaching: No Coaching Non-Responder

Behavioral: Behavioral: Booster

Interventions

Active ControlBEHAVIORAL

No APP based coaching, no human coaching, no rerandomization, no MRT

Active control

Continue with existing intervention plan

App & Human Coaching + Continue InterventionApp Coaching + Continue InterventionHuman Coaching + Continue InterventionNo Coaching + Continue Intervention

Increase intensity of human coaching

App & Human Coaching + Increase intensity in human coachingApp Coaching + Increase intensity in human coachingHuman Coaching + Increase intensity in human coachingNo Coaching + Increase intensity in human coaching

Add a booster session

App & Human Coaching + BoosterApp Coaching + BoosterHuman Coaching + BoosterNo Coaching + Booster

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • aged 18 above
  • family caregiver of an individual with a confirmed medical diagnosis of any type of dementia who has been residing in the community
  • having been providing care for ADLs and IADLs for at least 20 hours per week for at least one year prior to recruitment
  • have a smartphone
  • have mild to moderate stress (the 14-item Chinese version Perceived Stress Scale).

You may not qualify if:

  • having participated in any structured mind-body intervention, cognitive therapy, or structured psychosocial intervention in the 6 months prior to recruitment
  • having acute psychiatric and medical comorbidities that are potentially life-threatening (e.g. suicidal ideation) or that limit the caregivers' participation or adherence (e.g. acute psychosis)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

The Education University of Hong Kong

Hong Kong, Hong Kong

Location

Study Officials

  • Kee Lee Chou, PhD

    The Education University of Hong Kong

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Purpose
PREVENTION
Intervention Model
FACTORIAL
Model Details: Hybrid factorial - Sequential Multiple Assignment Randomized Trial (SMART), Micro Randomized Trial (MRT) experimental design with a 2x2+1 factorial design (with five arms) randomized clinical trial, 2 stage SMART and three MRTs
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Chair Professor of Social Policy

Study Record Dates

First Submitted

February 25, 2026

First Posted

March 3, 2026

Study Start

June 1, 2026

Primary Completion (Estimated)

November 30, 2027

Study Completion (Estimated)

November 30, 2027

Last Updated

May 18, 2026

Record last verified: 2026-05

Data Sharing

IPD Sharing
Will not share

Locations