NCT07443917

Brief Summary

The current study primarily aims to evaluate the presence of T. parvum in periodontal health and disease, and its correlation with clinical parameters. Subgingival plaque samples will be collected using sterile paper points then the samples will be analyzed using quantitative polymerase chain reaction (qPCR) to detect T. parvum and estimate its relative amount in the biofilm. The results may help clarify the association between T. parvum and periodontitis.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
112

participants targeted

Target at P50-P75 for all trials

Timeline
3mo left

Started Dec 2025

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress63%
Dec 2025Sep 2026

Study Start

First participant enrolled

December 1, 2025

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

February 23, 2026

Completed
7 days until next milestone

First Posted

Study publicly available on registry

March 2, 2026

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2026

Expected
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2026

Last Updated

March 2, 2026

Status Verified

February 1, 2026

Enrollment Period

6 months

First QC Date

February 23, 2026

Last Update Submit

February 23, 2026

Conditions

Periodontitis

Keywords

Treponema parvumSubgingival microbiomePeriodontitis

Outcome Measures

Primary Outcomes (1)

  • Relative abundance of T. parvum in subgingival biofilm

    Detection and relative abundance of T. parvum in subgingival biofilm measured by qPCR from subgingival plaque collected using sterile paper points

    At enrollment

Study Arms (2)

Periodontitis

Healthy periodontium

Eligibility Criteria

Age30 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Study population involves those who are attending the clinics of Periodontics in the College of Dentistry / University of Baghdad, in Baghdad / Iraq, and seeking for periodontal treatment. Eligible patients according to the pre-defined inclusion and exclusion criteria who will be invited to participate in this study.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

College of Dentistry, University of Baghdad

Baghdad, 10047, Iraq

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Extracted DNA isolated from subgingival plaque collected using sterile paper points. DNA will be retained at -20° for qPCR detection and quantification of T. parvum and repeat analyses as needed

MeSH Terms

Conditions

Periodontitis

Condition Hierarchy (Ancestors)

Periodontal DiseasesMouth DiseasesStomatognathic Diseases

Central Study Contacts

Mays Jaafar Dentist, B.D.S

CONTACT

009647712910127mays.allah2405@codental.uobaghdad.edu.iq

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Dentist

Study Record Dates

First Submitted

February 23, 2026

First Posted

March 2, 2026

Study Start

December 1, 2025

Primary Completion (Estimated)

June 1, 2026

Study Completion (Estimated)

September 1, 2026

Last Updated

March 2, 2026

Record last verified: 2026-02

Locations

IR(1)