Treatment Of Shallow Periodontal Pockets Using PRF As an Adjunct To Scaling And Root Planing In Periodontitis Patients

NCT05890157 | Unknown

• 1 other identifier: PRF as adjunct to ScRp
• Study Type: interventional
• Target: 12
• Locations: 0 countries
• Sites: N/A

Brief Summary

Platelet rich fibrin (PRF) has been widely used in regenerative dentistry since it provides plenty amount of growth factors that enhance wound healing and tissue regeneration. Platelet derived growth factor-BB (PDGF-BB) is a growth factor with essential functions such as regulation of cell migration, proliferation, and differentiation. This study aims to evaluate the efficacy of PRF in improving the clinical periodontal parameters and GCF level of PDGF-BB.

Conditions

Periodontitis

Outcome Measures

Primary Outcomes (2)

• Change in Clinical attachment level

  Using UNC-15 periodontal probe measured in mm

  Change from baseline to 1-month and change from baseline to 3-month

• Change in Periodontal pocket depth measured in mm

  Using UNC-15 periodontal probe measured in mm

  Change from baseline to 1-month and change from baseline to 3-month

Secondary Outcomes (3)

• Change in plaque index

  Change from baseline to 1-month and change from baseline to 3-month

• Change in bleeding on probing percentage

  Change from baseline to 1-month and change from baseline to 3-month

• Change in GCF level of platelet derived growth factor

  Change from baseline to 1-month and change from baseline to 3-month

Study Arms (2)

Test ScRp+PRF

EXPERIMENTAL

This site will treated by ScRp+PRF

Other: PRF

Control ScRp

NO INTERVENTION

This site will treated by ScRp only

Interventions

PRF OTHER

Split mouth randomized clinical trial will be the design of the study. 12 periodontitis patients with 24 opposite shallow periodontal pockets (4-6 mm in depth) will be selected. Randomization in this study will be achieved using toss of coin method in which periodontal pockets were designated either control site or test site. PRF will be used as an adjunct to scaling and root planing to treat the test sites. While control sites will be treated by scaling and root planing only. Clinal periodontal parameters will be recorded and GCF level of PDGF-BB will be measured at baseline and1- and 3- month follow-up visits to evaluate the healing response to the treatment.

Test ScRp+PRF

Eligibility Criteria

• Age: 20 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• periodontitis

You may not qualify if:

• Periodontal therapy for the last 3 months
• Medical history of systemic diseases such as diabetes.
• Patients wearing dental prosthesis
• Alcoholic patients
• Teeth with grade II mobility, endodontic lesions, and teeth with untreated caries

Sponsors & Collaborators

• University of Baghdad: lead

MeSH Terms

Conditions

Periodontitis

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: May 16, 2023
• First Posted: June 6, 2023
• Study Start: July 30, 2023
• Primary Completion: November 30, 2023
• Study Completion: December 30, 2023
• Last Updated: June 6, 2023

Record last verified: 2023-05