The Efficacy of Scaling and Root Planing on Endothelin-1 Level

NCT06784869 | Not Yet Recruiting

• 1 other identifier: 1/10/2024
• Study Type: interventional
• Target: 24
• Locations: 0 countries
• Sites: N/A

Brief Summary

Periodontitis is a chronic inflammatory disease resulting from bacterial invasion. Endothelin (ET-1) is a potent vasoconstrictor critical in the pathophysiology of periodontal diseases. Aim The present study aimed to measure the ET-1 concentrations in gingival crevicular fluid (GCF) at baseline, one and three months subsequently to non-surgical periodontal therapy. Material and methods Designed as a clinical trial, 24 periodontitis individuals will be voluntarily consented to participate. Following non-surgical periodontal treatment, GCF samples will be collected to determine the amount of endothelin-1 at baseline, one, and three months. Clinical periodontal parameters will be recorded.

Conditions

Periodontitis

Keywords

periodontitis; endotheiln-1; scaling and root surface debritment

Outcome Measures

Primary Outcomes (2)

• PPD

  changes in PPD after non-surgical periodontal treatment.

  3 months recall visits

• CAL

  changes in CAL after non-surgical periodontal treatment.

  3 months recall visits

Secondary Outcomes (1)

• ET-1

  3 months recall visits

Study Arms (1)

have generalized unstable periodontitis with a moderately deep pocket (4,5 or 6 mm).

EXPERIMENTAL

got generalized unstable periodontitis with a moderately deep pocket (4,5 or 6 mm) will undergo scaling and root surface debritment

Device: Scaling and root surface debritment

Interventions

Scaling and root surface debritment DEVICE

Patients with 4-6 mm pocket depth were participated in this study; clinical periodontal parameters (BOP, PLI, PPD, CAL) were recorded at the baseline visit. To ensure sampling accuracy, From the site two papers with GCF were sampled. Following sample collecting for GCF, Every patient received comprehensive mouth supragingival scaling with an ultrasonic scaler (WoodpEEKer® UDS-K) along with dental hygiene recommendations. One week later, the sites were irrigated with normal saline after being scaled and root planed (ScRp) with Gracey curette. Following completion of subgingival instrumentation, each patient returned to the clinic following 1 and 3 months for periodontal parameter recording and GCF collection. Throughout these sessions, every patient received reinstruction to engage in self-oral hygiene practices.

Also known as: Scaling and root planing

have generalized unstable periodontitis with a moderately deep pocket (4,5 or 6 mm).

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• systemically healthy
• Generalized unstable periodontitis with a moderately deep pocket (4,5 or 6 mm)

You may not qualify if:

• subjects who wore dental prosthesis
• teeth with grade II mobility,
• alcoholic and smoker, had treated caries
• underwent periodontal therapy within the last four months

Sponsors & Collaborators

• University of Baghdad: lead

MeSH Terms

Conditions

Periodontitis

Interventions

Weights and Measures; Root Planing

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Intervention Hierarchy (Ancestors)

Investigative Techniques; Dental Scaling; Dental Prophylaxis; Periodontics; Dentistry; Subgingival Curettage; Preventive Dentistry

Central Study Contacts

Sarah alrihaymee

CONTACT

07828802375; sarra.anwar1205a@codental.uobaghdad.edu.iq

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of periodontic department

Study Record Dates

• First Submitted: January 8, 2025
• First Posted: January 20, 2025
• Study Start: February 1, 2025
• Primary Completion: July 30, 2025
• Study Completion: September 30, 2025
• Last Updated: January 20, 2025

Record last verified: 2025-01