Intradialytic Rehabilitation and Functional Independence in Hemodialysis Patients

NCT07442240 | Completed

• 1 other identifier: HD-REHAB-2012
• Study Type: interventional
• Target: 56
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study evaluated whether a rehabilitation program performed during hemodialysis sessions could improve daily functioning and mobility in adults receiving maintenance hemodialysis. Participants took part in either exercise-based rehabilitation, breathing muscle training, or usual care. The study compared changes in functional independence and mobility before and after the rehabilitation period.

Conditions

Chronic Kidney Disease (Stages 4 and 5); Hemodialysis

Keywords

intradialytic exercise; rehabilitation; inspiratory muscle training; core stabilization; functional independence; mobility

Outcome Measures

Primary Outcomes (1)

• Six-Minute Walk Test

  Functional exercise capacity assessed as the distance walked in six minutes, measured according to standardized procedures.

  Baseline and after 10 weeks

Secondary Outcomes (6)

• Timed Up and Go Test (TUG)

  Baseline and after 10 weeks

• Five Times Sit-to-Stand Test (5STS)

  Baseline and after 10 weeks

• Maximal Inspiratory Pressure (MIP)

  Baseline and after 10 weeks

• Maximal Expiratory Pressure (MEP)

  Baseline and after 10 weeks

• Forced Vital Capacity (FVC)

  Baseline and after 10 weeks

Study Arms (3)

Dynamic Lumbar Stabilization Exercise (DLSE)

EXPERIMENTAL

Participants received a supervised intradialytic dynamic lumbar stabilization exercise program three times per week for 10 weeks in addition to usual care.

Behavioral: Dynamic Lumbar Stabilization Exercises

Respiratory Muscle Training (RMT)

EXPERIMENTAL

Participants received supervised respiratory muscle training during hemodialysis sessions three times per week for 10 weeks in addition to usual care.

Behavioral: Respiratory Muscle Training

Control Group

NO INTERVENTION

Participants received routine nephrological care during hemodialysis without additional exercise or rehabilitation interventions.

Interventions

Dynamic Lumbar Stabilization Exercises BEHAVIORAL

A structured intradialytic exercise program focusing on trunk stabilization and neuromuscular control, performed under supervision during hemodialysis sessions.

Dynamic Lumbar Stabilization Exercise (DLSE)

Respiratory Muscle Training BEHAVIORAL

Respiratory muscle training performed during hemodialysis using threshold-based breathing exercises under supervision.

Respiratory Muscle Training (RMT)

Eligibility Criteria

• Age: 25 Years - 45 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Adults aged 25 to 45 years.
• Diagnosis of chronic kidney disease undergoing maintenance hemodialysis.
• Receiving hemodialysis for at least 6 months.
• Hemodialysis schedule of three sessions per week, four hours per session.
• Clinically stable at the time of enrollment.
• Ability to participate in exercise and functional assessments.
• Provided written informed consent.

You may not qualify if:

• Acute medical conditions or unstable cardiovascular disease.
• Severe musculoskeletal, neurological, or orthopedic disorders limiting exercise participation.
• Severe cognitive impairment or inability to follow instructions.
• Uncontrolled hypertension or other conditions contraindicating exercise.
• Participation in another structured exercise or rehabilitation program during the study period.

Sponsors & Collaborators

• Bandırma Onyedi Eylül University: lead

MeSH Terms

Conditions

Renal Insufficiency, Chronic

Interventions

Breathing Exercises

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Mind-Body Therapies; Complementary Therapies; Therapeutics; Exercise Movement Techniques; Physical Therapy Modalities

Study Officials

• Serpil Çolak, PT, PhD

  Bandırma Onyedi Eylül University

  PRINCIPAL INVESTIGATOR

• Candan Z Algun, PT, PhD

  Medipol University

  STUDY DIRECTOR

• Gürkan Yurteri, MD

  Rentek Diyaliz Merkezi

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: Outcome assessments were performed by a physiotherapist who was blinded to group allocation.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Model Details: Participants were allocated to one of three parallel groups: dynamic lumbar stabilization exercises, inspiratory muscle training, and a control group receiving usual care.

Study Record Dates

• First Submitted: February 24, 2026
• First Posted: March 2, 2026
• Study Start: June 1, 2016
• Primary Completion: March 1, 2017
• Study Completion: June 1, 2017
• Last Updated: March 2, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share