Intraoperative Carotid Peak Systolic Velocity Variability in Liver Transplant Patients

NCT07442201 | Completed

• 1 other identifier: Inonu CPSV
• Study Type: observational
• Target: 42
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study was to evaluate carotid peak systolic velocity variability using intraoperative ultrasound and to determine whether this method is useful in the assessment of hemodynamic status and intravascular volume in liver transplantation. Previously, a similar study was performed in liver transplant intensive care unit, but no study was performed to evaluate intraperative fluid status with carotid ultrasonography.

Conditions

Liver Transplant Disorder

Outcome Measures

Primary Outcomes (1)

• CPSVv

  carotid peak systolic velocity variability

  During surgery: T0: Before vena cava inferior clamping T1: After vena cava inferior clamping

Study Arms (1)

Liver transplant recipients

After excluding patients with fulminant hepatic failure requiring emergency transplantation and those outside the age range of 18-65 years, 42 patients out of a total of 89 liver transplant recipients were included.

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Liver transplant recipients received at İnönü University Liver Transplant Institute between 18.09.2023 and 29.04.2024

You may qualify if:

• Adult patients scheduled for elective liver transplantation

You may not qualify if:

• fulminant hepatic failure requiring emergency transplantation, patients with carotid artery disease

Sponsors & Collaborators

• Inonu University: lead

Study Sites (1)

İnönü Üniversitesi Merkez Kampüsü (Elazığ Yolu 15.km) Battalgazi

Malatya, Turkey, 44280, Turkey (Türkiye)

Location

Related Publications (3)

• Ibarra-Estrada MA, Lopez-Pulgarin JA, Mijangos-Mendez JC, Diaz-Gomez JL, Aguirre-Avalos G. Respiratory variation in carotid peak systolic velocity predicts volume responsiveness in mechanically ventilated patients with septic shock: a prospective cohort study. Crit Ultrasound J. 2015 Dec;7(1):29. doi: 10.1186/s13089-015-0029-1. Epub 2015 Jun 26.

  PMID: 26123610 RESULT

• Roy A, Pachisia AV, Govil D, Kn J, Patel S, Harne R, Pal D, Reddy DM, Tyagi P, Pattajoshi S. Fluid Responsiveness in Critically Ill Patients Using Carotid Peak Systolic Velocity Variability: A New Frontier. Cureus. 2023 Jul 18;15(7):e42083. doi: 10.7759/cureus.42083. eCollection 2023 Jul.

  PMID: 37602090 RESULT

• Ramsingh D, Staab J, Flynn B. Application of perioperative hemodynamics today and potentials for tomorrow. Best Pract Res Clin Anaesthesiol. 2021 Dec;35(4):551-564. doi: 10.1016/j.bpa.2021.01.005. Epub 2021 Feb 4.

  PMID: 34801217 RESULT

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: associate professor

Study Record Dates

• First Submitted: May 21, 2025
• First Posted: March 2, 2026
• Study Start: September 18, 2023
• Primary Completion: April 29, 2024
• Study Completion: January 10, 2025
• Last Updated: March 2, 2026

Record last verified: 2023-09

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)