Perioperative Factors and Living Donor Liver Transplantation

NCT06312098 | Not Yet Recruiting

• 1 other identifier: KC21RISI0576
• Study Type: observational
• Target: 533
• Locations: 0 countries
• Sites: N/A

Brief Summary

Liver transplant surgery is one of the treatments provided to patients suffering from end-stage liver disease, and has a successful treatment prognosis. However, it is clear that patient management before, during, and after surgery is a difficult task for medical staff due to the complex clinical and pathological problems of end-stage liver disease. Moreover, the complex surgical technique of the liver transplant surgery itself and the severe hemodynamic fluctuations and multi-organ dysfunction that patients experience during the surgery have been shown to have a tremendous impact on the patient's prognosis after surgery. A study on which clinical, laboratory, and hemodynamic factors experienced by patients during the perioperative period, including before, during, and after surgery, affect the survival rate of patients and transplanted organs. will definitely be helpful in the treatment of patients suffering from end-stage liver disease.

Conditions

Liver Transplant Disorder

Outcome Measures

Primary Outcomes (1)

• Incidence of postreperfusion syndrome

  mean blood pressure decreases by 30% based on the value on preoperative day

  during surgery

Study Arms (2)

no-remote ischemic preconditioning group

patients who did not receive remote ischemic preconditioning

paired remote ischemic preconditioning group

patients who receive remote ischemic preconditioning

Other: remote ischemic preconditioning (RIPC)

Interventions

remote ischemic preconditioning (RIPC) OTHER

After induction of anesthesia, the paired RIPC group took the RIPC intervention on the upper arm in the lateral position. The RIPC intervention was applied using a manual cuff inflator, which consisted of three cycles of 5-min inflation of the blood pressure cuff (to 250 mmHg, or to 50 mmHg higher than the preoperative SBP), followed by 5-min deflation of the cuff. In the no-RIPC group, a blood pressure cuff was also applied on the upper arm but was not inflated.

paired remote ischemic preconditioning group

Eligibility Criteria

• Age: 19 Years - 79 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Data from adult patients undergoing elective living donor liver transplantation at Seoul St. Mary's Hospital were retrospectively collected with the electronic medical record system.

You may qualify if:

• adults
• elective surgery
• American Society of Anesthesiologists (ASA) physical status classification system I, II, III

You may not qualify if:

• American Society of Anesthesiologists (ASA) physical status classification system IV, V

Sponsors & Collaborators

• Min Suk Chae: lead

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: professor

Study Record Dates

• First Submitted: March 8, 2024
• First Posted: March 15, 2024
• Study Start: April 1, 2024
• Primary Completion: June 1, 2024
• Study Completion: July 1, 2024
• Last Updated: March 18, 2024

Record last verified: 2024-03

Data Sharing

• IPD Sharing: Will not share