Individually Tailored, Supervised, Remote Exercise Intervention to Improve Physical Function for Stage I-III Gastroesophageal Cancer Survivors, PRECISE Trial

NCT07439484 | Not Yet Recruiting

• 2 other identifiers: 25-0954NCI-2026-00630
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

This clinical trial tests an individually tailored, supervised, remote exercise intervention to improve physical function for stage I-III gastroesophageal cancer survivors. Modern treatments for gastroesophageal cancer are effective at treating the cancer but are often aggressive, can be difficult for patients to tolerate, and can lead to significant debilitation and a loss of independence. Exercise is one promising intervention that could improve physical function in patients with gastroesophageal cancer after finishing systemic treatment. Home based exercise interventions in patients with cancer during and after chemotherapy can improve fatigue and function. An individually tailored, supervised, remote exercise intervention may improve physical function for stage I-III gastroesophageal cancer survivors.

Conditions

Clinical Stage I Esophageal Adenocarcinoma American Joint Committee on Cancer (AJCC) v8; Clinical Stage I Esophageal Squamous Cell Carcinoma AJCC v8; Clinical Stage I Gastric Cancer AJCC v8; Clinical Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8; Clinical Stage II Esophageal Adenocarcinoma AJCC v8; Clinical Stage II Esophageal Squamous Cell Carcinoma AJCC v8; Clinical Stage II Gastric Cancer AJCC v8; Clinical Stage III Esophageal Adenocarcinoma AJCC v8; Clinical Stage III Esophageal Squamous Cell Carcinoma AJCC v8; Clinical Stage III Gastric Cancer AJCC v8; Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8; Clinical Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8

Outcome Measures

Primary Outcomes (1)

• Percentage of participants who attend at least 80% of the exercise sessions and complete the post-intervention functional assessment

  Will use descriptive statistics to summarize the participant population, feasibility metrics, and safety data. The study will be deemed feasible if \> 60% (12 or more) of the 20 enrolled participants are retained.

  At 8 weeks

Secondary Outcomes (18)

• Percentage of patients who are screened that qualify for the intervention

  Up to 16 months

• Percentage of eligible patients who consent to participate in the intervention

  Up to '6 months

• Percentage of eligible participants who meet the duration and intensity goals for the aerobic and resistance exercises by the end of the study period

  Up to 8 weeks

• Change in physical function

  From baseline to 8 weeks

• Change in grip strength

  From baseline to 8 weeks

Study Arms (1)

Supportive care (Remote exercise intervention)

EXPERIMENTAL

Patients receive access to the Moterum application and complete remotely delivered, supervised exercise sessions, over 1 hour, 3 times per week for 8 weeks. Sessions consist of both aerobic and resistance training exercises. Patients also receive written instructions and videos of strengthening exercises. Patients undergo blood sample collection throughout the study.

Other: Actigraphy; Procedure: Biospecimen Collection; Other: Educational Intervention; Other: Electronic Health Record Review; Other: Exercise Intervention; Other: Internet-Based Intervention; Other: Physical Performance Testing; Other: Survey Administration

Interventions

Actigraphy OTHER

Ancillary studies

Supportive care (Remote exercise intervention)

Biospecimen Collection PROCEDURE

Undergo blood sample collection

Also known as: Biological Sample Collection, Biospecimen Collected, Specimen Collection

Supportive care (Remote exercise intervention)

Educational Intervention OTHER

Receive written instructions

Also known as: Education for Intervention, Intervention by Education, Intervention through Education, Intervention, Educational

Supportive care (Remote exercise intervention)

Electronic Health Record Review OTHER

Ancillary studies

Supportive care (Remote exercise intervention)

Exercise Intervention OTHER

Compete exercise sessions

Supportive care (Remote exercise intervention)

Internet-Based Intervention OTHER

Receive access to Moterum application

Supportive care (Remote exercise intervention)

Physical Performance Testing OTHER

Ancillary studies

Also known as: Physical Fitness Testing, Physical Function Testing

Supportive care (Remote exercise intervention)

Survey Administration OTHER

Ancillary studies

Supportive care (Remote exercise intervention)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults ≥ 18 years old at the start of study treatment
• Diagnosis of early-stage (Stage I, II, III) esophageal, gastroesophageal junction, or gastric cancer. Histology can be adenocarcinoma, squamous cell carcinoma, or poorly differentiated carcinoma
• Treated with at least one systemic therapy (chemotherapy or immunotherapy) and within 12 months of completing curative intent gastroesophageal cancer (GEC) treatment
• Have evidence of physical function impairment, defined as a SPPB score of \< 12) at baseline
• Ability to understand English and the willingness to sign a written informed consent document

You may not qualify if:

• Patients with stage I disease who underwent endoscopic resection or surgery alone without perioperative systemic therapy
• Patients with stage IV disease or unresectable locally advanced disease taking a palliative treatment approach without a clearly defined end of treatment
• Patients currently receiving ongoing systemic therapy for GEC or another malignancy
• Patients who are unable to provide informed consent
• Any other condition or pre-existing co-morbidity that would, in the Investigator's judgment, contraindicate the participation in the study due to safety concerns with study procedures
• Currently participating in another exercise intervention research study seeking to improve functional status, alleviate frailty, muscle strength, exhaustion/fatigue, or cognitive function

Sponsors & Collaborators

• Jonsson Comprehensive Cancer Center: lead

Study Sites (1)

UCLA / Jonsson Comprehensive Cancer Center

Los Angeles, California, 90095, United States

Location

MeSH Terms

Interventions

Actigraphy; Specimen Handling; Early Intervention, Educational; Educational Status; Methods; Exercise Test

Intervention Hierarchy (Ancestors)

Monitoring, Physiologic; Diagnostic Techniques and Procedures; Diagnosis; Accelerometry; Investigative Techniques; Clinical Laboratory Techniques; Child Health Services; Community Health Services; Health Services; Health Care Facilities Workforce and Services; Preventive Health Services; Socioeconomic Factors; Population Characteristics; Heart Function Tests; Diagnostic Techniques, Cardiovascular; Respiratory Function Tests; Diagnostic Techniques, Respiratory System; Ergometry

Study Officials

• Jingran Ji, MD

  UCLA / Jonsson Comprehensive Cancer Center

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Jingran Ji, MD

CONTACT

310-829-5471; jingranji@mednet.ucla.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 10, 2026
• First Posted: February 27, 2026
• Study Start (Estimated): September 1, 2026
• Primary Completion (Estimated): September 1, 2027
• Study Completion (Estimated): September 1, 2028
• Last Updated: May 11, 2026

Record last verified: 2026-02

Locations

US (1)