NCT07437027

Brief Summary

AimoftheWork To assess the efficiency of Opoid free anaesthesia with paravertebral block compared to opoid free anaesthesia with erector spinae plane block in patients undergoing Thoracotomy.

Trial Health

63
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
86

participants targeted

Target at P50-P75 for not_applicable

Timeline
0mo left

Started Mar 2026

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress87%
Mar 2026Jul 2026

First Submitted

Initial submission to the registry

February 22, 2026

Completed
5 days until next milestone

First Posted

Study publicly available on registry

February 27, 2026

Completed
2 days until next milestone

Study Start

First participant enrolled

March 1, 2026

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2026

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2026

Expected
Last Updated

February 27, 2026

Status Verified

February 1, 2026

Enrollment Period

3 months

First QC Date

February 22, 2026

Last Update Submit

February 22, 2026

Conditions

Post Thoracotomy Pain

Keywords

Opoid free anesthesia

Outcome Measures

Primary Outcomes (1)

  • Total morphine consumption for the first 24 hours postoperative

    Within the first 24 hours postoperative

Secondary Outcomes (1)

  • Postoperative pain

    At 0,2,6,12,24 hours post operative

Study Arms (2)

Group A : thoracic para vertebral block

EXPERIMENTAL

Patients in this arm will receive ultrasound guided thoracic paravertebral block at the T5 level using 20 ml of 0.5% bupivacaine protocol for lateral thoracotomy

Procedure: Group A :Thoracic paravertebral block

Group B : erector spinae plane block

EXPERIMENTAL

Patients in this arm will receive ultrasound guided erector spinae plane block at the T5 level using 20 ml of 0.5% bupivacaine as part of an opoid sparing anesthesia protocol for lateral thoracotomy

Procedure: Erector Spinae Plane Block

Interventions

Group A :Thoracic paravertebral blockPROCEDURE

Ultrasound guided thoracic paravertebral block performed at the T5 level using 20 ml of 0.5% bupivacaine for postoperative analgesia in patients undergoing lateral thoracotomy

Group A : thoracic para vertebral block
Erector Spinae Plane BlockPROCEDURE

ultrasound guided erector spinae plane block will be performed at the T5 level using 20 ml of 0.5% bupivacaine as part of an opoid sparing anesthesia protocol for lateral thoracotomy

Group B : erector spinae plane block

Eligibility Criteria

Age18 Years - 70 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Patients age between 18 and 70 .
  • Patients with ASAII and IIIstatus.
  • Patients undergoing open surgical Thoracotomy as in lobectomy, pneumonectomy, segmentectomy and decortication.
  • Gender both males and females.
  • Refusal of the patient.
  • Allergy to local anesthetic
  • Infection of the skin at the site of local infiltration
  • Cardiovascular problems (arrhythmia, heart block, SVT,AF, multiple extra systole).
  • Any contraindication to regional anesthesia as coagulopathy
  • Patients with chronic pain or on opoid medication preoperative

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Kasr al aini hospital

Cairo, Kasr Alaini, Egypt

Location

Related Publications (4)

  • Doan LV, Augustus J, Androphy R, Schechter D, Gharibo C. Mitigating the impact of acute and chronic post-thoracotomy pain. J Cardiothorac Vasc Anesth. 2014 Aug;28(4):1048-56. doi: 10.1053/j.jvca.2014.02.021. No abstract available.

    PMID: 25107721BACKGROUND

  • Benyamin R, Trescot AM, Datta S, Buenaventura R, Adlaka R, Sehgal N, Glaser SE, Vallejo R. Opioid complications and side effects. Pain Physician. 2008 Mar;11(2 Suppl):S105-20.

    PMID: 18443635BACKGROUND

  • Marshall K, McLaughlin K. Pain Management in Thoracic Surgery. Thorac Surg Clin. 2020 Aug;30(3):339-346. doi: 10.1016/j.thorsurg.2020.03.001. Epub 2020 Apr 29.

    PMID: 32593366BACKGROUND

  • Mamoun N, Wright MC, Bottiger B, Plichta R, Klinger R, Manning M, Raghunathan K, Gulur P. Pain Trajectories After Valve Surgeries Performed via Midline Sternotomy Versus Mini-Thoracotomy. J Cardiothorac Vasc Anesth. 2022 Sep;36(9):3596-3602. doi: 10.1053/j.jvca.2022.05.007. Epub 2022 May 10.

    PMID: 35641410RESULT

Central Study Contacts

Eman Mamdouh Mahmoud Hussien (emanmmh), Assistant lecturer

CONTACT

201002087146Eman.mamdouh31@gmail.com

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Lecturer of anesthesia

Study Record Dates

First Submitted

February 22, 2026

First Posted

February 27, 2026

Study Start

March 1, 2026

Primary Completion

June 1, 2026

Study Completion (Estimated)

July 1, 2026

Last Updated

February 27, 2026

Record last verified: 2026-02

Locations

EG(1)