Effects of Exercise During Pregnancy on the Long-term Metabolic Health of Mothers and Their Offspring

NCT07435857 | Completed

• 1 other identifier: 2021YFC2700700
• Study Type: observational
• Target: 221
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study was to assess the long-term metabolic effects of gestational exercise on overweight and obese women and their offspring 8-10 years post-intervention.

Conditions

Metabolic Health

Keywords

Exercise; Obesity; Follow-up; Metabolism; Maternal-offspring

Outcome Measures

Primary Outcomes (1)

• OGTT

  75-g oral glucose tolerance test （0h，2h，mmol/L）

  8-10 years

Secondary Outcomes (4)

• BMI

  8-10 years

• anthropometric measures

  8-10 years

• insulin resistance

  8-10 years

• lipid profile

  8-10 years

Study Arms (2)

exercise group

We conduct a follow-up study of a randomized controlled trial (RCT) in which the impact of prenatal exercise on the incidence of gestational diabetes mellitus (GDM) was investigated. Mother-offspring pairs underwent follow up

Behavioral: exercise

control group

We conduct a follow-up study of a randomized controlled trial (RCT) in which the impact of prenatal exercise on the incidence of gestational diabetes mellitus (GDM) was investigated. Mother-offspring pairs underwent follow up

Interventions

exercise BEHAVIORAL

The present study is a prospective follow-up of a randomized controlled trial (RCT) that was conducted in the Department of Obstetrics and Gynecology, Peking University First Hospital, from December 2014 to April 2017. In this RCT, 300 obese/overweight pregnant women (prepregnancy BMI ≥24 kg/m²) at \<12+6 weeks of gestation were randomized to exercise (n=150) and control groups (n=150), and the efficacy of regular exercise in early pregnancy to prevent GDM among overweight/obese pregnant Chinese women was investigated. The patients allocated to the exercise group were assigned to a cycling program (3 times per week, at least 30 min/session, rating of perceived exertion 12-14); the program was initiated within 3 days of randomization and continued until 37 weeks of gestation. The patients in the control group maintained their usual daily activities. The original RCT has been reported previously （Wang, C.Am. J. Obstet. Gynecol. 2017, 216 (4), 340-351.)

exercise group

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This follow-up of a randomized trial included 300 overweight/obese pregnant women (prepregnancy BMI ≥24, \<12⁺⁶ weeks gestation) from Peking University First Hospital (Dec 2014-Apr 2017). They were randomized to an exercise group (n=150, cycling three times/week, ≥30 min/session) or control group (n=150, usual activities). After excluding those who missed the OGTT (18 exercise, 17 control), 132 and 133 mother-offspring pairs, respectively, were included.

You may qualify if:

• \- 132 mothers in the exercise group and 133 mothers in the control group in the previous RCT trial who had OGTT results and their offsprings were eligible for follow-up

Sponsors & Collaborators

• Peking University First Hospital: lead

Study Sites (1)

Peking University First Hospital

Beijing, 100034, China

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Mothers and their offspring, after an 8-14 hour fast, underwent blood sample collection. Maternal assessments included a 75-g OGTT with blood sampling at 120 minutes. Plasma glucose and insulin were measured via hexokinase and electrochemiluminescence methods, respectively. Insulin resistance was calculated using the HOMA equation. Fasting lipid profiles (total cholesterol, triglycerides, HDL-C, LDL-C) were also measured.

MeSH Terms

Conditions

Motor Activity; Obesity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Behavior; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Chen Wang

  Peking University Frist hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associated professor

Study Record Dates

• First Submitted: February 17, 2026
• First Posted: February 27, 2026
• Study Start: June 1, 2024
• Primary Completion: November 15, 2024
• Study Completion: November 15, 2024
• Last Updated: February 27, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)