Effects of Cherry Consumption on Metabolic Health

NCT07155915 | Completed

• 1 other identifier: PRR-C05-i03-I-000143
• Study Type: interventional
• Target: 27
• Locations: 1 country
• Sites: 1

Brief Summary

This study is designed to evaluate the effects of daily sweet cherry consumption on markers of metabolic health in adults. Cherries are rich in bioactive compounds, such as anthocyanins and phenolic acids, which may help reduce oxidative stress, inflammation, and early risk factors for conditions like type 2 diabetes and cardiovascular disease. Participants will consume 280 grams of fresh sweet cherries every day for 42 consecutive days. Blood and urine samples will be collected at four time points: before the intervention (baseline), at day 21, at day 42 (end of the intervention), and two weeks after stopping cherry consumption. The study will measure changes in blood sugar regulation, markers of inflammation, oxidative stress, liver and kidney function, and immune response. Waist circumference and body mass index will also be recorded. The aim of this study is to test whether daily cherry consumption can support metabolic health in healthy adults and to provide data that may inform larger and longer clinical trials in the future.

Conditions

Metabolic Health

Keywords

cherry consumption; metabolic health; phenolic compounds

Outcome Measures

Primary Outcomes (10)

• Changes in fasting glucose

  Baseline, Day 21, Day 42 and 2 weeks post-intervention

• Changes in HbA1c

  Baseline, Day 21, Day 42 and 2 weeks post-intervention

• Changes in estimated average glucose

  Baseline, Day 21, Day 42 and 2 weeks post-intervention

• Changes in insulin

  Baseline, Day 21, Day 42 and 2 weeks post-intervention

• Changes in IL-6

  Baseline, Day 21, Day 42 and 2 weeks post-intervention

• Changes in AGP-1

  Baseline, Day 21, Day 42 and 2 weeks post-intervention

• Changes in C-reactive protein

  Baseline, Day 21, Day 42 and 2 weeks post-intervention

• Changes in gluthatione peroxidase

  Baseline, Day 21, Day 42 and 2 weeks post-intervention

• Changes in gluthatione reductase

  Baseline, Day 21, Day 42 and 2 weeks post-intervention

• Changes in glutamate dehydrogenase

  Baseline, Day 21, Day 42 and 2 weeks post-intervention

Secondary Outcomes (31)

• Changes in aspartate aminotransferase

  Baseline, Day 21, Day 42 and 2 weeks post-intervention

• Changes in alanine transaminase

  Baseline, Day 21, Day 42 and 2 weeks post-intervention

• Changes in gamma-glutamyl transferase

  Baseline, Day 21, Day 42 and 2 weeks post-intervention

• Changes in total bilirubin

  Baseline, Day 21, Day 42 and 2 weeks post-intervention

• Changes in conjugated bilirubin

  Baseline, Day 21, Day 42 and 2 weeks post-intervention

Study Arms (1)

Daily Sweet Cherry Consumption

EXPERIMENTAL

Participants in this arm will consume 280 grams of fresh sweet cherries (Prunus avium, "Prime-Giant" variety) every day for 42 consecutive days.

Dietary Supplement: Sweet cherries, 280 g daily for 42 days

Interventions

Sweet cherries, 280 g daily for 42 days DIETARY_SUPPLEMENT

Participants will consume 280 grams of fresh sweet cherries daily for 42 consecutive days. Cherries are provided in pre-weighed portions to be consumed in the morning on an empty stomach

Daily Sweet Cherry Consumption

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 18-65 years old
• Healthy individuals with no known metaboli disorders

You may not qualify if:

• Alcohol consumption
• Smoking
• Adverse or allergic reaction to cherries
• Use of antibiotics, anxiolytics, or dietary supplements
• Pregnancy or lactation
• Weight changes greater than 10% in the previous year.

Sponsors & Collaborators

• Instituto Politécnico da Guarda: lead

Study Sites (1)

Instituto Politécnico da Guarda

Guarda, Portugal

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: August 20, 2025
• First Posted: September 4, 2025
• Study Start: May 14, 2024
• Primary Completion: July 23, 2024
• Study Completion: July 23, 2024
• Last Updated: September 4, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

PT (1)