Effect of Erector Spinae Plane Block on Cerebral Oxygenation During One-Lung Ventilation

NCT07432230 | Completed

• 1 other identifier: 2025-KAEK-038
• Study Type: interventional
• Target: 102
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to evaluate the effect of the erector spinae plane block, used to reduce postoperative pain, on cerebral oxygenation in thoracic surgery patients undergoing one-lung ventilation in the lateral decubitus position.

Conditions

One Lung Ventillation (OLV); Erector Spina Plan Block; Near Infrared Spectroscopy; Cerebral Desaturation; Intraoperative Analgesic Use

Keywords

Erector Spinae Plane Block; One Lung Ventilation; Near İnfrared Spectroscopy

Outcome Measures

Primary Outcomes (1)

• Change from baseline in cerebral oxygen saturation (ΔrSO₂) during one-lung ventilation (OLV)

  Cerebral oxygen saturation (rSO₂, %) will be measured using near-infrared spectroscopy (NIRS). ΔrSO₂ is defined as rSO₂ at each predefined intraoperative time point minus baseline rSO₂

  Pre-intubation; intraoperatively at 0, 5, 10, 20, 30, and 60 minutes following intubation; and immediately before and after extubation

Secondary Outcomes (2)

• Incidence of Right Cerebral Desaturation During OLV

  Before intubation; during the operation at 0, 5, 10, 20, 30, and 60 minutes after intubation; and immediately before and after extubation

• Instantaneous remifentanil requirement during one-lung ventilation (OLV)

  Before intubation; during the operation at 0, 5, 10, 20, 30, and 60 minutes after intubation; and immediately before and after extubation

Study Arms (2)

Study Group

ACTIVE COMPARATOR

Patients who received a preoperative erector spinae plane block

Procedure: Erector Spinae Plane Block

Control Group

PLACEBO COMPARATOR

Patients who did not receive a preoperative erector spinae plane block

Procedure: A preoperative erector spinae plane block will not be administered

Interventions

Erector Spinae Plane Block PROCEDURE

In the study group, a single ultrasound-guided erector spinae plane block will be administered preoperatively using a total volume of 20 mL, consisting of 5 mL of 2% prilocaine hydrochloride, 10 mL of 0.5% bupivacaine, and 5 mL of 0.9% sodium chloride.

Study Group

A preoperative erector spinae plane block will not be administered PROCEDURE

A preoperative erector spinae plane block will not be administered

Control Group

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients aged 18-80 years
• With an American Society of Anesthesiologists (ASA) physical status of I-III
• Glasgow Coma Scale (GCS) score of 13-15
• Scheduled for thoracic surgery requiring one-lung ventilation

You may not qualify if:

• Patients undergoing emergency surgery
• Those younger than 18 years or older than 84 years
• Patients with an American Society of Anesthesiologists (ASA) physical status of IV or V
• Patients who refused to participate in the study
• Those with a history of brain surgery for any reason
• Patients with defects in the frontal region preventing placement of near-infrared spectroscopy probes
• Patients with distorted thoracic vertebral anatomy for any reason resulting in inadequate ultrasonographic imaging for block performance
• Patients with a known allergy to local anesthetics
• Patients with neurological disorders such as Alzheimer's disease or dementia
• Patients who were illiterate and/or unable to establish effective communication

Sponsors & Collaborators

• Kayseri City Hospital: lead

Study Sites (1)

Kayseri City Hospital

Kayseri, Kocasinan/KAYSERİ, 38080, Turkey (Türkiye)

Location

Related Publications (2)

• Roberts ML, Lin HM, Tinuoye E, Cohen E, Flores RM, Fischer GW, Weiner MM. The Association of Cerebral Desaturation During One-Lung Ventilation and Postoperative Recovery: A Prospective Observational Cohort Study. J Cardiothorac Vasc Anesth. 2021 Feb;35(2):542-550. doi: 10.1053/j.jvca.2020.07.065. Epub 2020 Jul 27.

  PMID: 32861541 RESULT

• Mukaihara K, Hasegawa-Moriyama M, Kanmura Y. Contralateral cerebral hemoglobin oxygen saturation changes in patients undergoing thoracotomy with general anesthesia with or without paravertebral block: a randomized controlled trial. J Anesth. 2017 Dec;31(6):829-836. doi: 10.1007/s00540-017-2402-7. Epub 2017 Aug 23.

  PMID: 28836009 RESULT

Related Links

• Evaluation of Cerebral Oxygenation During One-lung Ventilation in Diabetic Patients Undergoing Lung Resection: A Prospective and Observational Study

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medical Resident, Department of Anesthesiology

Model Details: Prospective Randomized Controlled Study

Study Record Dates

• First Submitted: January 14, 2026
• First Posted: February 25, 2026
• Study Start: March 1, 2025
• Primary Completion: October 30, 2025
• Study Completion: October 30, 2025
• Last Updated: February 25, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)