Effect of Different Volumes of Erector Spinae Plane Block on Postoperative Opioid Consumption After Total Abdominal Hysterectomy

NCT07533760 | Completed

• 1 other identifier: 2021/629
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

his study aims to investigate the effects of different volumes of ultrasound-guided erector spinae plane block (ESPB) on postoperative pain and opioid consumption in patients undergoing total abdominal hysterectomy. The researchers aim to determine whether varying the volume of local anesthetic in the ESPB can reduce the amount of morphine required by patients and improve pain scores during the first 24 hours after surgery.

Conditions

Postoperative Pain; Abdominal Hysterectomy; Pain

Outcome Measures

Primary Outcomes (1)

• Total Morphine Consumption

  The total amount of morphine (in milligrams) consumed by the patient via the Patient-Controlled Analgesia (PCA) device.

  First 24 hours postoperatively

Secondary Outcomes (2)

• Numerical Rating Scale (NRS) Scores for Pain

  At postoperative 30 minutes, 2nd, 6th, 12th, and 24th hours

• Number of Blocked Dermatomes

  20 minutes after the block procedure

Study Arms (2)

Group I

ACTIVE COMPARATOR

Patients in Group I received a preoperative bilateral ultrasound-guided erector spinae plane block (ESPB) with 20 ml of 0.25% bupivacaine hydrochloride (prepared by combining 10 ml of 0.5% bupivacaine hydrochloride with 10 ml of saline) for each side.

Procedure: Erector Spinae Plane Block

Group II

ACTIVE COMPARATOR

Patients in Group I received a preoperative bilateral ultrasound-guided erector spinae plane block (ESPB) with 30 ml of 0.25% bupivacaine hydrochloride (prepared by combining 15 ml of 0.5% bupivacaine hydrochloride with 15 ml of saline) for each side.

Procedure: Erector Spinae Plane Block

Interventions

Erector Spinae Plane Block PROCEDURE

The ESPB will be performed at the T8-T9 vertebral levels. The T7 vertebra, aligned with the inferior angles of the scapulae, will be identified, and the T8 vertebra will be located one level below via palpation. Patients will be placed in the prone position, and skin preparation will be performed with 10% povidone-iodine. Local anesthesia of the skin and subcutaneous tissue will be provided with 3 ml of 2% lidocaine at the target injection site. Under ultrasound guidance, a sterile-covered linear probe (8 MHz) will be used to visualize the T8 spinous process in the horizontal plane at the midline. The probe will then be rotated to the longitudinal plane, approximately 3 cm lateral to the midline, to visualize the transverse process and the overlying erector spinae muscle. A 22-gauge, 80-mm block needle will be advanced in-plane in a cranio-caudal direction until it contacts the transverse process. After confirming the position between the erector spinae muscle and the transverse proces

Group I; Group II

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients aged between 18 and 65 years.
• Patients with American Society of Anesthesiologists (ASA) physical status I-III.
• Patients scheduled to undergo elective total abdominal hysterectomy surgery.

You may not qualify if:

• Obese patients (Body Mass Index \> 30 kg/m²).
• Patients with local skin infection at the site of needle insertion.
• Patients with a known allergy to any of the medications used in the study.
• Patients with coagulopathy.
• Patients with chronic opioid consumption.
• Patients with an inability to use the Patient-Controlled Analgesia (PCA) device.
• Patients with advanced hepatic or renal failure.
• Patients who refuse to participate in the study.

Sponsors & Collaborators

• Şule Arıcan: lead

Study Sites (1)

Necmettin Erbakan University Faculty of Medicine

Konya, 42040, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Pain, Postoperative; Pain

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Neurologic Manifestations; Signs and Symptoms

Study Officials

• Şule Arıcan, Assoc. Prof.

  Necmettin Erbakan University Faculty of Medicine, Department of Anesthesiology and Reanimation

  PRINCIPAL INVESTIGATOR

• Hasan Çekdemir, specialist

  Hadim State Hospital, Department of Anesthesiology and Reanimation

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: April 10, 2026
• First Posted: April 16, 2026
• Study Start: January 1, 2022
• Primary Completion: June 1, 2022
• Study Completion: June 1, 2022
• Last Updated: April 16, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)