NCT07427966|Not Yet Recruiting
Psychobiological Markers to Improve Diagnosis and to Predict Affective Episodes in Bipolar Disorder
MoodCatcher
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MoodCatcher
Sponsor study identifier
observational
600
0 countries
N/A
Study Start
April 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
December 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
This trial has two studies. In study 1, the investigators will explore the relationships between three psychobiological factors (sleep patterns, motor activity, and decision-making ability). The investigators aim to investigate how these factors interact in BD patients. This understanding will facilitate the distinction of BD patients from patients with recurrent depressive disorder (MDD) and healthy controls. In study 2, the investigators will continue following patients with bipolar disorder and use the interplay between the three psychobiological factors to develop early markers of full-blown affective episodes.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
December 5, 2025
Actual (reported)February 23, 2026
Actual (reported)April 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
December 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
December 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Sleep onset
Smartwatch measure of sleep onset.
12 weeks for study 1; 1 year for study 2
Motor activity
Smartwatch data on number of steps each half time of the day
12 weeks for study 1; 1 year for study 2
Learning rate
We will administer a reward learning task and use computational modeling to extract a learning rate.
12 weeks for study 1; 1 year for study 2
150 Individuals with a diagnosis of bipolar disorder will participate in studies 1 and 2
250 patients from three affective clinics in the Stockholm Region (Northwest Psychiatry, North Stockholm Psychiatry, Southwest Psychiatry) who have been referred for assessment for bipolar disorder. Based on clinical experience, approximately 20% (approximately 50 patients) will ultimately be diagnosed with bipolar disorder, while the remaining 200 patients will retain their diagnosis of recurrent depression and be included as a comparison group in study 1 only. The 50 patients newly diagnosed with bipolar disorder will be included in studies 1 and 2.
200 Individuals with no major psychiatric disorder will participate in study 1 only.
* Healthy control comes from the Stockholm region general population. * Patients comes from different psychiatric clinics in the Stockholm region.
First Submitted
December 5, 2025
First Posted
February 23, 2026
Study Start
April 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
Clinical Validation Study for EDIT-B Test: an Aid for Differential Diagnosis of Bipolar Disorder, Based on RNA Editing Blood Biomarkers
Reward sensitivity
We will administer a valence go/no go task and use computational model to extract reward sensitivity.
12 weeks for study 1; 1 year for study 2
Motivational bias
We will administer a valence go/no go task and use computational model to extract a motivational bias.
12 weeks for study 1; 1 year for study 2
Effort discounting
We will administer an effort discounting task and use computational modeling to extract an effort discounting parameter.
12 weeks for study 1; 1 year for study 2
Foraging exit threshold
We will administer foraging task and calculate a foraging exit threshold.
12 weeks for study 1; 1 year for study 2
Sleep duration
Smartwatch measure of sleep duration.
12 weeks for study 1; 1 year for study 2
Sleep quality
Smartwatch measure of sleep quality.
12 weeks for study 1; 1 year for study 2
Questionnaire
12 weeks for study 1; 1 year for study 2
Questionnaire
12 weeks for study 1; 1 year for study 2
Questionnaire
12 weeks for study 1; 1 year for study 2
Questionnaires
12 weeks for study 1; 1 year for study 2
Questionnaire
12 weeks for study 1; 1 year for study 2
Contact the study team to confirm eligibility.
December 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
February 23, 2026
Record last verified: 2025-10
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