Can Genetics Predict Treatment Response to a Computerized Self-help Program for Depression?
Genetic Predictors of Response to a Computerized Self-help Program for Depression
1 other identifier
interventional
500
1 country
1
Brief Summary
The goal of this project is to determine whether genetic information can be used to predict response to an internet-based treatment of depression. Several studies now indicate that completing an internet-based treatment for depression, called Deprexis, can significantly improve symptoms of depression. However, not everyone improves. The purpose of this study is to determine whether genetic profile can predict who is likely to improve.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable major-depressive-disorder
Started Mar 2013
Typical duration for not_applicable major-depressive-disorder
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 20, 2013
CompletedStudy Start
First participant enrolled
March 1, 2013
CompletedFirst Posted
Study publicly available on registry
March 26, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2015
CompletedNovember 9, 2015
November 1, 2015
2.7 years
February 20, 2013
November 6, 2015
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Quick Inventory of Depressive Symptomatology (Self-Report) (QIDS-SR-16)
Administred every 2 weeks while the participant is engaged in the online deprexis treatment program to measure depression symptom severity.
Secondary Outcomes (6)
Hamilton Depression Rating Scale (HAM-D)
The HAM-D will be completed during the pre- and post-treatment phone interviews to assess depression symptom severity.
Inventory of Depression and Anxiety Symptoms (IDAS)
The IDAS will be completed as part of the pre- and post-treatment questionnaires to assess for symptoms of depression and anxiety.
Psychiatric Diagnostic Screening Questionnaire (PDSQ)
The PDSQ will be completed as part of the pre- and post-treatment questionnaires to screen for the most common DSM-IV Axis I disorders..
Risky Families Questionnaire (RFQ)
The RFQ will be completed as part of the pre-treatment questionnaires to assess early familial experiences and the harshness of family climate.
Massachusetts General Hospital Antidepressant Treatment History Questionnaire (ATRQ)
The ATRQ will be administered as part of the pre-treatment questionnaires to evaluate psychotropic efficacy.
- +1 more secondary outcomes
Study Arms (2)
Computerized self-help program for depression
ACTIVE COMPARATORParticipants will have access to a computerized self-help program for depression, called deprexis, for 8 weeks.
Wait List Control
NO INTERVENTIONParticipants randomly assigned to a "wait list control" condition will wait 8 weeks after assignment before they can access the deprexis program.
Interventions
For 8 weeks, participants will engage in a computerized self-help program for depression, called deprexis. This program consists of 10 content modules representing different psychotherapeutic approaches broadly consistent with a cognitive-behavioral perspective. Modules are organized as simulated dialogues in which the program explains and illustrates concepts and techniques, engages the user in exercises, and continuously asks users to respond by selecting from response options. Subsequent content is then tailored to the users' responses, resulting in a simulated conversational flow. Participants can access the self-help program as often as they would like and since it is self-guided, they will determine how often they access the material. Each module can be completed in 10 to 60 minutes, depending on the user's reading speed, interest, motivation, and individual path through the program.
Eligibility Criteria
You may qualify if:
- English-speaking
- Have reliable access to the internet (i.e., dialup or broadband access)
- Be willing to donate saliva for DNA research
- Have a current symptoms of depression
- Be stable on medication and/or therapy (i.e. no changes within 2 weeks of study entry)
You may not qualify if:
- Any diagnosis of a psychotic or bipolar disorder
- Meeting for alcohol/drug dependence in the past year
- Having current suicidal risk warranting crisis intervention
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Texas at Austinlead
- Brown Universitycollaborator
Study Sites (1)
The University of Texas at Austin
Austin, Texas, 78713, United States
Related Publications (1)
Beevers CG, Pearson R, Hoffman JS, Foulser AA, Shumake J, Meyer B. Effectiveness of an internet intervention (Deprexis) for depression in a united states adult sample: A parallel-group pragmatic randomized controlled trial. J Consult Clin Psychol. 2017 Apr;85(4):367-380. doi: 10.1037/ccp0000171. Epub 2017 Feb 23.
PMID: 28230390DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Christopher G Beevers, PhD
The University of Texas at Austin
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
February 20, 2013
First Posted
March 26, 2013
Study Start
March 1, 2013
Primary Completion
November 1, 2015
Study Completion
November 1, 2015
Last Updated
November 9, 2015
Record last verified: 2015-11