Pilot Study of a Brain Health Program in Senior Centers

NCT07424443 | Recruiting

• 1 other identifier: 2025P002540
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators will evaluate a brain health programs in older adults with subjective cognitive decline. The primary aim of the study is to determine the credibility, expectancy, feasibility, acceptability, appropriateness, fidelity, and satisfaction of the program delivered in the senior centers.

Conditions

Memory Loss (Excluding Dementia); Lifestyle (Sedentary Behavior and Physical Activity); Lifestyle Risk Reduction; Healthy Lifestyle Behaviors; Dementia Prevention

Keywords

Cogntive Aging; Health Promotion; Mindfulness; Community Health Services; Feasibility Studies; Alzheimer Disease / prevention & control; Exercise; Diet; Sleep; Social Interaction; Cognitive Stimulation; Smoking; Alcohol Drinking

Outcome Measures

Primary Outcomes (2)

• Rates of Treatment Completion

  We will assess the acceptability of treatment by calculating the proportion of participants who attend ≥ 6/8 treatment sessions (≥ 70% good, ≥ 80% excellent).

  8 Weeks

• Client Satisfaction Questionnaire

  Assesses patient satisfaction with the program. Higher total scores (min = 3, max = 12) indicate greater satisfaction (≥ 70% good, ≥ 80% excellent)

  8 Weeks

Secondary Outcomes (8)

• Credibility and Expectancy Questionnaire

  0 Weeks

• Rates of Recruitment

  0 Weeks

• Rate of Enrollment

  0 Weeks

• Rates of Valid Activity Watch Data (10 or more hours of wear time)

  8 Weeks

• Rates of Missing Outcomes Data

  8 Weeks

Study Arms (1)

My Healthy Brain

EXPERIMENTAL

My Healthy Brain is an 8-week group program delivered via 90-minute meetings led by a clinical psychologist or trainee. It provides education on the link between dementia and lifestyle factors, including poor exercise, sleep, diet/nutrition, mental and social stimulation, alcohol, and smoking. My Healthy Brain participants learn evidence-based mindfulness and behavior change skills to address common barriers to healthy habits, such as stress and setting achievable goals. My Healthy Brain participants wear an activity watch to monitor lifestyle changes during the program.

Behavioral: My Healthy Brain

Interventions

My Healthy Brain BEHAVIORAL

My Healthy Brain is an 8-week group program delivered via 90-minute meetings led by a clinical psychologist pr trainee. It provides education on the link between dementia and lifestyle factors, including poor exercise, sleep, diet/nutrition, mental and social stimulation, alcohol, and smoking. My Healthy Brain participants learn evidence-based mindfulness and behavior change skills to address common barriers to healthy habits, such as stress and setting achievable goals. My Healthy Brain participants wear an activity watch to monitor lifestyle changes during the program.

My Healthy Brain

Eligibility Criteria

• Age: 50 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Aged ≥ 50
• Subjective cognitive decline (SCD; e.g., forgetting information, getting lost, and repeating oneself)
• Able to self-identify at least 1 modifiable lifestyle risk factors for dementia to change during the program (physically inactive, poor sleep, non-adherence to Mediterranean diet, alcohol use, tobacco use, socially isolated or lonely, mental inactivity)
• Absence of significant cognitive impairment (assessed using Short Blessed Test71 ≤ 9)
• Self-reported English proficiency/literacy
• Ability and willingness to participate and complete all study-related activities

You may not qualify if:

• Dementia or other neurodegenerative disease per patient self-report or disclosure
• Psychosis, uncontrolled schizophrenia or schizoaffective disorder, uncontrolled bipolar disorder, or uncontrolled substance dependence/abuse
• Active self-report of suicidal ideation / high risk of suicide
• Serious medical illness expected to worsen during the study
• Self-reported safety issues with initiating lifestyle change

Sponsors & Collaborators

• Massachusetts General Hospital: lead
• Massachusetts Association of Councils on Aging and Senior Center Directors, Inc.: collaborator

Study Sites (1)

Massachusetts General Hospital

Boston, Massachusetts, 02114, United States

RECRUITING

Related Publications (1)

• Mace RA, Law ME, Cohen JE, Ritchie CS, Okereke OI, Hoeppner BB, Brewer JA, Bartels SJ, Vranceanu AM; My Healthy Brain Team. A Mindfulness-Based Lifestyle Intervention for Dementia Risk Reduction: Protocol for the My Healthy Brain Feasibility Randomized Controlled Trial. JMIR Res Protoc. 2024 Nov 21;13:e64149. doi: 10.2196/64149.

  PMID: 39571150 BACKGROUND

MeSH Terms

Conditions

Memory Disorders; Sedentary Behavior; Motor Activity; Risk Reduction Behavior; Alzheimer Disease; Smoking; Alcohol Drinking

Condition Hierarchy (Ancestors)

Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior; Dementia; Brain Diseases; Central Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders; Drinking Behavior

Central Study Contacts

My Healthy Brain Clinical Research Coordinator

CONTACT

617-643-9406; mghmyhealthybrain@mgb.org

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor of Psychology

Model Details: Single arm, open pilot study

Study Record Dates

• First Submitted: February 13, 2026
• First Posted: February 20, 2026
• Study Start: March 3, 2026
• Primary Completion (Estimated): August 1, 2026
• Study Completion (Estimated): August 1, 2026
• Last Updated: February 20, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)