Instant Message-delivered Personalised Acceptance and Commitment Therapy (IMPACT) for Neuropsychiatric Symptoms in Persons With Mild Cognitive Impairment

NCT07420426 | Recruiting

• 1 other identifier: IMPACT2025
• Study Type: interventional
• Target: 160
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to develop an automated instant message-delivered intervention (i.e., EMI) for people with mild cognitive impairment to reduce their NPS, and to investigate the feasibility and effectiveness of the intervention.

Conditions

Mild Cognitive Impairment (MCI)

Keywords

mild cognitive impairment; acceptance and commitment therapy; neuropsychiatric symptoms

Outcome Measures

Primary Outcomes (1)

• MBI-C scores

  The primary outcome will be MBI-C scores to assess NPSs. A higher MBI-C scores will indicate a higher level of neuropsychiatric symptoms.

  at baseline, 10th week and 24th week

Secondary Outcomes (6)

• Depressive symptoms (PHQ-9)

  at baseline, 10th week and 24th week

• Anxiety symptoms (GAD-7)

  at baseline, 10th week and 24th week

• Quality of life (EuroQol 5-dimension 5-level questionnaire [EQ-5D-5L])

  at baseline, 10th week and 24th week

• Cognitive functions (HK-MoCA)

  at baseline, 10th week and 24th week

• Acceptance of negative emotions and valued-based actions (AAQ-II)

  at baseline, 10th week and 24th week

Study Arms (2)

Intervention group

EXPERIMENTAL

Participants in intervention group will receive the EMI for 9 weeks. Based on the steps of mobile message development recommended by Abroms, et al., our multidisciplinary team - including a neurologist, nurses, clinical psychologists and gerontologists - will develop an ACT message content library and protocol for IM delivery (i.e. EMI).

Behavioral: automated instant message-guided neuropsychiatric symptoms management

Control group

ACTIVE COMPARATOR

The control group will receive instant messages about general mental health management from the HKSAR Government website in 9 weeks, which is open to the public (https://www.shallwetalk.hk/en/mental-well-being/mental-well-being-is-related-to-you/), with reminder text messages of follow-up surveys.

Behavioral: general mental health management

Interventions

automated instant message-guided neuropsychiatric symptoms management BEHAVIORAL

Participants in intervention group will receive the EMI for 9 weeks. Based on the steps of mobile message development recommended by Abroms, et al., we will develop a message content library and protocol for EMI delivery.

Intervention group

general mental health management BEHAVIORAL

Participants in control group will receive the messages for 9 weeks. The control group will receive instant messages about general mental health management from the HKSAR Government website, which is open to the public (https://www.shallwetalk.hk/en/mental-well-being/mental-well-being-is-related-to-you/), with reminder text messages of follow-up surveys.

Control group

Eligibility Criteria

• Age: 50 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Community-dwelling adults aged ≥ 50 years
• HK-MoCA score ranged from 18 to 22
• MBI-C ≥7
• SCD-9 ≥3
• IADL =18
• Able to read and communicate in Chinese
• Able to use the text or voice messaging function on a smartphone

You may not qualify if:

• Clinical diagnosis of dementia
• Clinical diagnosis of psychiatric disease
• Currently participating in any type of psychological or behavioural intervention for NPSs
• Currently taking psychiatric medication
• Currently receiving acute care or post-acute hospitalization care

Sponsors & Collaborators

• The University of Hong Kong: lead

Study Sites (1)

The University of Hong Kong

Hong Kong, Hong Kong

RECRUITING

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MeSH Terms

Conditions

Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Officials

• Doris Sau Fung Yu, Professor

  School of nursing, The University of Hong Kong

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Doris Sau Fung Yu, Professor

CONTACT

+852 3917 6319; dyu1@hku.hk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: February 12, 2026
• First Posted: February 19, 2026
• Study Start: December 8, 2025
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: May 18, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

HK (1)