Yizhi Baduanjin for Patients With Cognitive Impairment

NCT06453941 | Terminated

• 1 other identifier: UW23-082
• Study Type: interventional
• Target: 1
• Locations: 1 country
• Sites: 1

Brief Summary

The trial is designed to examine whether Yizhi Baduanjin could slow down and improve in memory, logical thinking and cerebral function in patients with mild cognitive impairment (MCI). 30 MCI patients will be recruited and randomly assigned to Yizhi Baduanjin intervention group control group for 6 months. The primary outcome is changes in Montreal Cognitive Assessment (MoCA) questionnaire; other outcome includes Cognitive Function Assessment questionnaire.

Conditions

Mild Cognitive Impairment (MCI)

Keywords

Mild Cognitive Impairment (MCI); Alzheimers Disease (AD); Non-drug intervention; Baduanjin

Outcome Measures

Primary Outcomes (1)

• Changes in Montreal Cognitive Assessment (MoCA )

  Questionnaire with 8 categories, 33 items with a total score of 30.

  Baseline, 1-month, 3-month, 6-month

Secondary Outcomes (1)

• Changes in Cognitive Function Assessment

  Baseline, 1-month, 3-month, 6-month

Study Arms (2)

Yizhi Baduanjin group

EXPERIMENTAL

The Yizhi Baduanjin group will practice Yizhi Baduanjin as intervention for 6 months, and the participants will be examined for assessment indicators on the 1st, 3rd, 6th month after the intervention started.

Other: Yizhi Baduanjin (Eight Pieces of Brocades for Mental Health Promotion)

Control group

NO INTERVENTION

The control group has no intervention until 6 months after the intervention of the experimental group started, but the participants will be examined for the same assessment indicators together with the experimental group.

Interventions

Yizhi Baduanjin (Eight Pieces of Brocades for Mental Health Promotion) OTHER

Yizhi Baduanjin (Eight Pieces of Brocades for Mental Health Promotion) is a newly compiled routine developed on the foundation of the traditional Baduanjin (Eight Pieces of Brocades), which is a traditional Chinese medical health exercise consisted of eight movements to be practiced by oneself.

Yizhi Baduanjin group

Eligibility Criteria

• Age: 60 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• to 75 years old.
• Voluntarily and sign the informed consent form.
• Non-handicapped, able to complete the cognitive function examination.
• Fulfill the diagnostic criteria.
• Montreal Cognitive Assessment (MoCA )Scale \< 26

You may not qualify if:

• Fail to comply to the requirements, or fail to complete the examination.
• Unwilling or unable to learn and practice the Yizhi Baduanjin routine.

Sponsors & Collaborators

• The University of Hong Kong: lead

Study Sites (1)

The University of Hong Kong

Hong Kong, 000000, Hong Kong

Location

MeSH Terms

Conditions

Cognitive Dysfunction; Alzheimer Disease

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders; Dementia; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases

Study Officials

• Zhangjin Zhang, MMed, PhD

  The University of Hong Kong

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: April 10, 2023
• First Posted: June 12, 2024
• Study Start: May 1, 2023
• Primary Completion: March 1, 2025
• Study Completion: April 1, 2025
• Last Updated: June 17, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

HK (1)