Trials Sponsors Conditions Drugs Pricing

Conditions

Cardiac Surgery Associated - Acute Kidney Injury Critical Illness

Keywords

Acute kidney injuryBiomarkerPoor outcomeAKI occurrencePrognostic valueCardiac Surgery Associated - Acute Kidney Injury

Outcome Measures

Primary Outcomes (1)

AKI occurrence within 7 days
AKI was defined based on the Kidney Disease Improving Global Outcomes (KDIGO) criteria.
7 days

Secondary Outcomes (7)

Moderate and severe AKI occurrence within 7 days
7 days
AKI occurrence within 3 days
3 days
Major adverse kidney events
Perioperative
Receipt of renal replacement treatment
Perioperative
Mortality
30 days
+2 more secondary outcomes

Interventions

Standard care "bundle"Other

The management for AKI patients were performed by implementing a standard care "bundle" suggested by the Kidney Disease Improving Global Outcome (KDIGO) guideline.

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Age18 Years - 90 Years

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodNon-Probability Sample

Study Population

All high-risk AKI patients who underwent cardiac surgery at Zhongshan Hospital Affiliated to Fudan University.CSA-AKI is the second most common cause of AKI in the intensive care setting (after sepsis) and is independently associated with increased morbidity and mortality. The incidence of cardiac surgery-associated AKI (CSA-AKI) varies from 5% to 42%.

You may qualify if:

Sponsors & Collaborators

Guowei Tu
Otherlead

Study Sites (2)

Zhongshan hospital, Fudan university

Shanghai, Shanghai Municipality, 200030, China

Zhongshan hospital

Shanghai, Shanghai Municipality, 200032, China

Biospecimen

Retention: SAMPLES WITHOUT DNA

2-5ml blood and urine samples for biomarker analysis will be collected before surgery and within 6-12 hours after surgery. Plasma (EDTA), serum, and urine supernatants were frozen within 2 h of sample collection, stored at -80#, and thawed immediately before analysis.

MeSH Terms

Conditions

Critical IllnessAcute Kidney Injury

Condition Hierarchy (Ancestors)

Disease AttributesPathologic ProcessesPathological Conditions, Signs and SymptomsRenal InsufficiencyKidney DiseasesUrologic DiseasesFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesMale Urogenital Diseases

Study Officials

Zhe Luo, MD
Fudan University
STUDY DIRECTOR

Enrollment

319 participants (actual enrollment reported by the registry).

Study Design

Study Type: observational
Observational Model: COHORT
Time Perspective: PROSPECTIVE
Sponsor Type: OTHER
Responsible Party: SPONSOR INVESTIGATOR
PI Title: Scientific Secretary for Cardiac Intensive Care Center

Study Record Dates

First Submitted

February 3, 2026

First Posted

February 18, 2026

Study Start

February 23, 2026

Actual (reported)

Prognostic Value of Novel Biomarkers on Adverse Renal Outcomes in High-Risk Cardiac Surgery Patients

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (7)

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (2)

Biospecimen

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (7)

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (2)

Biospecimen

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations