Effect of Different VV ECMO Flows on Lung Perfusion Monitored by EIT

NCT05778292 | Unknown

• 1 other identifier: ECMO20221119
• Study Type: observational
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate the feasibility of using electric impedance tomography (EIT) to monitor lung perfusion during veno-venous (VV) extracopreal membrane oxygenation (ECMO) support, as well as the effect of different ECMO flows on lung perfusion monitored by EIT.

Conditions

Critical Illness

Keywords

VV ECMO; EIT; Lung perfusion

Outcome Measures

Primary Outcomes (1)

• Lung perfusion at different VV ECMO flows

  Effect of Different VV ECMO Flows (ECMO flow at 4.5L,3.5L,2.5L,1.5L, and after ECMO withdrawal) on lung perfusion distribution Monitored by EIT

  up to 24hour

Secondary Outcomes (5)

• Lung ventilation at different VV ECMO flows

  up to 24hour

• Lung deadspace region at different VV ECMO flows

  up to 24hour

• Lung shunt region at different VV ECMO flows

  up to 24hour

• Lung ventilation/perfusion matching at different VV ECMO flows

  up to 24hour

• Recirculation at different VV ECMO flows

  up to 24hour

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with respiratory failure supported on VV ECMO

You may qualify if:

• Patients aged ≥ 18 and ≤ 70 years；
• Patients supported with VV ECMO for respiratory failure；
• Patients are intubated and mechanically ventilated.

You may not qualify if:

• EIT contraindications such as chest wound dressing, pacemaker installation, defibrillator, etc;
• Patients who did not sign the informed consent form;
• Pulmonary embolism;
• Pneumothorax;
• Medium to plenty of chest water;
• Atrial fibrillation or other malignant arrhythmia leads to a decrease in cardiac output;
• Refractory shock;
• Severe chronic heart and lung disease has existed in the past;
• BMI\>35 kg/m2;
• Intra-abdominal pressure \>20mmHg.

Sponsors & Collaborators

• Union Hospital, Tongji Medical College, Huazhong University of Science and Technology: lead

Study Sites (1)

Xiaobo Yang

Wuhan, Hubei, 430022, China

RECRUITING

MeSH Terms

Conditions

Critical Illness

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Xiaobo Yang, prof.

CONTACT

008602785351606; want.tofly@aliyun.com

You Shang, prof.

CONTACT

008602785351607; you_shanghust@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Professor

Study Record Dates

• First Submitted: February 8, 2023
• First Posted: March 21, 2023
• Study Start: January 1, 2023
• Primary Completion: December 31, 2024
• Study Completion: December 31, 2024
• Last Updated: March 21, 2023

Record last verified: 2023-03

Locations

CN (1)