Bedside Air Quality in ICU and Clinical Outcome

NCT06201754 | Withdrawn

• 1 other identifier: IIT20230456B
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 3

Brief Summary

There is a close relationship between air pollution and cardiovascular disease. Small particulate matter and inhalable particulate matter in the air are the main components of air pollution, which can enter the respiratory system and enter the bloodstream through alveoli. These particles are believed to have the ability to trigger inflammatory responses, which are one of the important factors leading to cardiovascular disease. Some studies suggest that air pollution may increase the risk of cardiac events, such as arrhythmia and myocardial infarction, by affecting the autonomic function of the heart. Air pollution in the ICU may have a series of adverse effects on critically ill patients, especially those with underlying heart disease or elderly patients, but there is no relevant research to confirm this.

Conditions

Critical Illness

Outcome Measures

Primary Outcomes (1)

• PM2.5 exposures and hospital acquired infections

  The correlation between the total amount or number of PM2.5 exposures (area under the curve and greater than 5ug/m3) and hospital acquired infections after admission to the ICU

  six month

Secondary Outcomes (7)

• Air quality indicators and arrhythmias

  six month

• Medical operations and air quality indicators

  six month

• PM10, CO2 and hospital acquired infections

  six month

• Air quality indicators and mechanical ventilation

  six month

• Air quality indicators and the use of vasoactive drugs

  six month

Study Arms (1)

ICU patients

We will include all ICU inpatients who undergo bedside air quality monitoring

Other: Measure air quality

Interventions

Measure air quality OTHER

Measure air quality, including PM2.5、PM10

ICU patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study includes all patients in need of intensive care

You may qualify if:

• Age greater than 18 years old
• The subject or their family members fully understand the patient's instructions and sign an informed consent form

You may not qualify if:

• Expected ICU hospitalization days are less than 2 days
• Pregnant women

Sponsors & Collaborators

• First Affiliated Hospital of Zhejiang University: lead

Study Sites (3)

First Affiliated Hospital of Zhejiang University School of Medicine

Hangzhou, Zhejiang, 310000, China

Location

The First People's Hospital of Pinghu

Pinghu, China

Location

Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University

Taizhou, China

Location

MeSH Terms

Conditions

Critical Illness

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Lingtong Huang

  First Affiliated Hospital of Zhejiang University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctor

Study Record Dates

• First Submitted: January 2, 2024
• First Posted: January 11, 2024
• Study Start: January 2, 2024
• Primary Completion: May 1, 2025
• Study Completion: May 1, 2025
• Last Updated: August 7, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

CN (3)