Acute Effect of Apple Cider Vinegar on Postprandial Plasma Malondialdehyde in Adult With Obesity

NCT07414875 | Completed

• 1 other identifier: 25-12-1899
• Study Type: interventional
• Target: 46
• Locations: 1 country
• Sites: 1

Brief Summary

Research on the benefits of apple cider vinegar has tended to focus on its hypoglycemic effects and lipid profile changes during long-term consumption, without exploring its acute effects on oxidative stress during short-term consumption. Therefore, this study aimed to determine whether apple cider vinegar consumption affects postprandial plasma MDA levels in obese adults. The hypothesis of this study is that apple cider vinegar consumption has an acute effect on changes in postprandial plasma MDA levels in obese adult subjects. Subject criteria are adults aged 19-59 years; obese nutritional status; based on a BMI of ≥ 25.0 kg/m² (according to the Asia-Pacific classification); in good general health. Exclusion criteria include pregnancy, breastfeeding, and menopause; consuming alcohol; intolerance to apple cider vinegar or fermented products. This preliminary study, a parallel, randomized, open-label, controlled clinical trial, compared two groups: a control group receiving a standard diet without apple cider vinegar, and an intervention group receiving a standard diet with a single dose of apple cider vinegar.

Conditions

Oxidative Stress; Obesity

Outcome Measures

Primary Outcomes (1)

• Change in Postprandial Plasma Malondialdehyde Levels

  Change in plasma malondialdehyde concentration from baseline (fasting) to the postprandial time point following acute administration of apple cider vinegar compared with control.

  Baseline (fasting) to 3 hours postprandial

Study Arms (2)

Apple Cider Vinegar Group

EXPERIMENTAL

Participants in this group received a single acute dose of apple cider vinegar administered before or with a standard test meal. Plasma malondialdehyde levels were measured before and after the meal.

Dietary Supplement: apple cider vinegar

Control Group

NO INTERVENTION

Participants in this group received a standard test meal without apple cider vinegar. Plasma malondialdehyde levels were measured before and after the meal.

Interventions

apple cider vinegar DIETARY_SUPPLEMENT

A single oral dose of apple cider vinegar was administered before a standard test meal to assess post-meal changes in plasma malondialdehyde levels.

Apple Cider Vinegar Group

Eligibility Criteria

• Age: 19 Years - 59 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Adults aged 19-59 years.
• Obese, based on a BMI of ≥ 25.0 kg/m² (according to the Asia-Pacific classification).
• In good general health.
• No diagnosed chronic diseases (e.g diabetes mellitus, heart disease, kidney disease, cancer, hepatitis, or chronic infections).
• Willing to participate in the entire study and sign an informed consent form.

You may not qualify if:

• Pregnant, breastfeeding, or menopausal women.
• Alcohol consumption.
• Intolerance to apple cider vinegar or fermented products.

Sponsors & Collaborators

• Indonesia University: lead

Study Sites (1)

Ministry of Youth and Sports of the Republic of Indonesia (KEMENPORA RI)

Jakarta, Jakarta Special Capital Region, Indonesia

Location

MeSH Terms

Conditions

Obesity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Ika Handayani, MD

  Faculty of Medicine, University of Indonesia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Participants are randomly assigned into two parallel groups: an apple cider vinegar intervention group and a control group. Each group receives a single acute intervention followed by postprandial assessment of plasma malondialdehyde levels.

Study Record Dates

• First Submitted: February 11, 2026
• First Posted: February 17, 2026
• Study Start: February 4, 2026
• Primary Completion: May 6, 2026
• Study Completion: May 11, 2026
• Last Updated: June 9, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

ID (1)