The Effect of Apple Cider Vinegar Supplementation on 24-hour Urine Chemistry in Adults

NCT07389226 | Not Yet Recruiting

• 1 other identifier: IRB25-0715
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This is a single-center prospective cohort study to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry.

Conditions

Kidney Stones; Urine Specimen Collection

Keywords

urine specimen collection; kidney stones

Outcome Measures

Primary Outcomes (4)

• Measure changes in citrate in urine.

  to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry.

  From Enrollment to 2 weeks

• Measure changes in Urine PH

  to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry.

  From enrollment to 2 weeks

• Measure changes in calcium in urine.

  to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry.

  from enrollment to 2 weeks

• Measure changes in calcium oxalate in urine

  to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry.

  From Enrollment to 2 weeks

Study Arms (1)

kidney stone patients and healthy participants

EXPERIMENTAL

Each participant will be asked to complete a basic metabolic panel prior to initiating the study to ensure that no baseline metabolic derangements exist. On day 1, participants will complete a 24-hour urine collection and 48-hour food diary at home. Participants will then consume an ACV gummy containing 60 meq daily for 14 consecutive days.

Dietary Supplement: Apple Cider Vinegar

Interventions

Apple Cider Vinegar DIETARY_SUPPLEMENT

Goli Apple Cider Vinegar gummies

kidney stone patients and healthy participants

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Controls: Adults above the age of 18.
• Kidney stone patients: Adults above the age of 18.
• History of majority (\>50%) calcium oxalate kidney stones

You may not qualify if:

• Anyone with a history of calcium phosphate stones (\>50% calcium phosphate), uric acid stones, struvite stones, recent urinary tract instrumentation (\<30 days), or recurrent urinary tract infections.
• Any individual who has had ACV outside of normal consumption in the prior month will be excluded.
• Any individual who has a history of a negative reaction (increased acid reflux, allergy) to ACV will also be excluded.
• Any individual with chronic kidney disease, underlying acid base disorder will also be excluded.

Sponsors & Collaborators

• University of Chicago: lead

Study Sites (1)

The University of Chicago

Chicago, Illinois, 60637, United States

Location

MeSH Terms

Conditions

Kidney Calculi

Condition Hierarchy (Ancestors)

Nephrolithiasis; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Urolithiasis; Urinary Calculi; Male Urogenital Diseases; Calculi; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Study Officials

• Luke Reynolds

  The University of Chicago Medical Center

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Luke Reynolds

CONTACT

7137926105; lukereynolds@bsd.uchicago.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 27, 2026
• First Posted: February 5, 2026
• Study Start: May 1, 2026
• Primary Completion (Estimated): January 1, 2028
• Study Completion (Estimated): February 1, 2028
• Last Updated: April 20, 2026

Record last verified: 2026-04

Locations

US (1)