Investigation of Preoperative Factors Influencing the Outcome of Motor Deficits in Patients Undergoing Lumbar Microdiskectomy

NCT07413302 | Recruiting

• 1 other identifier: 292/2024
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 3

Brief Summary

Lumbar disc herniations may result in lower limb weakness. In such cases, there is a strong indication for surgical intervention through microdiscectomy. This clinical study aims to investigate preoperative factors that may influence the postoperative outcomes of patients undergoing this procedure.

Conditions

Motor Deficits; Lumbar Discectomy; Muscle Weakness; Paresis; Lumbar Disc Herniation

Keywords

microdiscectomy; lumbar disc herniation; motor deficit; lower limb paresis; prognostic factors microdiscectomy; disc herniation outcome

Outcome Measures

Primary Outcomes (2)

• Muscle Strength

  The strength of lower main muscles will be assessed and will be rated according to the Medical Research Council Scale for Muscle Strength. The scale takes values between 0 and 5, with 5 being the best possible (healthy).

  Perioperative

• Duration of paresis before surgical treatment

  Time between the initiation of paresis and surgical treatment measured in days

  Baseline

Secondary Outcomes (8)

• Age

  Baseline

• Obesity

  Baseline

• Diabetes Melitus

  Baseline

• Hernia location

  Baseline

• Hernia morphology

  Baseline

Study Arms (1)

Patients with limb paresis due to lumbar disk herniation undergoing microdiskectomy

Patients suffering from motor deficit because of lumbar disk herniation scheduled to undergo single-level microdiskectomy.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients visiting the three recruitment hospitals, all located in North Greece.

You may qualify if:

• Patients suffering from lower limb paresis (motor deficit) caused by lumbar disk herniation undergoing a single-level microdiskectomy
• Age (years) \> 17

You may not qualify if:

• Age (years) \< 18
• Medical history of lumbar spine surgery
• Absence of limb paresis
• Motor deficit caused by other than disk herniation aetiologies
• Reoperation within 6 months after microdiskectomy
• Microdiskectomy at more than one level
• Cauda equina syndrome
• Peripheral neuropathy

Sponsors & Collaborators

• Aristotle University Of Thessaloniki: lead
• Hippocration General Hospital: collaborator
• General Hospital of Kavala: collaborator
• European Interbalkan Medical Center: collaborator

Study Sites (3)

General Hospital of Kavala

Kavala, 65500, Greece

RECRUITING

Hippokration General Hospital

Thessaloniki, 54642, Greece

RECRUITING

European Interbalkan Medical Center

Thessaloniki, 57001, Greece

RECRUITING

MeSH Terms

Conditions

Neurologic Manifestations; Muscle Weakness; Paresis; Intervertebral Disc Displacement

Condition Hierarchy (Ancestors)

Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Muscular Diseases; Musculoskeletal Diseases; Neuromuscular Manifestations; Pathologic Processes; Spinal Diseases; Bone Diseases; Hernia; Pathological Conditions, Anatomical

Study Officials

• Panagiotis Sarlis

  Aristotle University Of Thessaloniki

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Panagiotis Sarlis

CONTACT

+302513501449; psarlis@gapps.auth.gr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 6 Months
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 24, 2026
• First Posted: February 17, 2026
• Study Start: July 3, 2024
• Primary Completion (Estimated): June 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: February 17, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

GR (3)