Multilevel Peer-to-Peer HPV Vaccination and Wellness Educational Program in School Based Health Centers

NCT07412743 | Enrolling By Invitation DMC

• 2 other identifiers: R01MD019038-01A1R01MD019038
• Study Type: interventional
• Target: 4,000
• Locations: 1 country
• Sites: 1

Brief Summary

School-based health centers (SBHCs) are an important setting to improve health through detecting, managing and preventing chronic illness. Too few people are educated about the human papillomavirus (HPV), which can prevent tens of thousands of deaths from cancer each year. PEER will evaluate a program to increase health and wellness and the use of SBHCs for primary and preventive care. If successful, PEER could significantly increase the use of SBHCs, and decrease HPV-associated cancers and, thus, reduce the burden of cancer in the United States.

Conditions

School Health Services

Outcome Measures

Primary Outcomes (1)

• Rate of Vaccination for HPV (n of patients with HPV vaccination/n of patients eligible for vaccination)

  Vaccination among eligible clinic patients, and time to vaccination

  6 and 12 months

Secondary Outcomes (3)

• Rates of new patients to the clinic (n of new patients/n of established patients)

  6 and 12 months

• Rate of use of other SBHC services (primary care visits, wellness assessments) (n of patients with primary care visits/n of new and established patients)

  6 and 12 months

• Rate of vaccination for other adolescent vaccinations (COVID-19, flu, Meningitis, or uptick of other vax's (TDAP, MMR, etc.)) (n of patients with additional vaccination among new and eligible clinic patients)

  6 and 12 months

Study Arms (2)

Control time (pre-implementation)

NO INTERVENTION

All participating SBHCs offer routine HPV vaccination recommendations as part of clinical care and SBHC staff will continue to follow standard procedures to deliver these services. Further, all SBHCs have existing relationships with the affiliated schools, so the delivery of these healthcare services in the context of schools will not deviate from usual care.

Intervention (post-implementation)

EXPERIMENTAL

Intervention components (mailers, provider materials, and peer-to-peer educational sessions) will be administered during the intervention portion of each cluster.

Behavioral: Mailers; Behavioral: Provider Materials; Behavioral: Peer-to-Peer Educational Sessions

Interventions

Mailers BEHAVIORAL

Letter and fact sheet (infographic) mailed to caregivers of 9-14 year-olds and to teens 15-18, with optional phone call for "confidential patients" aged 15-18.

Intervention (post-implementation)

Provider Materials BEHAVIORAL

Clinic team/staff training based on qualitative interviews, recommended strategies and evidence-based interventions. Training materials include FAQs and Smart phrases. FAQs and informational sheets containing the same content as the mailers distributed in clinic to teen SBHC patients and their caregivers.

Intervention (post-implementation)

Peer-to-Peer Educational Sessions BEHAVIORAL

Educational sessions delivered in schools by OSBHA interns. Session content includes SBHC information and HPV awareness.

Intervention (post-implementation)

Eligibility Criteria

• Age: 9 Years - 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Aged 9-18
• New or established patients
• Flagged if due for an HPV vaccine

You may not qualify if:

• \- None

Sponsors & Collaborators

• Kaiser Permanente: lead
• National Institute on Minority Health and Health Disparities (NIMHD): collaborator

Study Sites (1)

Kaiser Permanente Center for Health Research

Portland, Oregon, 97227, United States

Location

Study Officials

• Amanda Petrik, PhD

  Kaiser Permanente

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: The PEER study is a concurrent stepped wedge and patient randomized trial that will take place in 9 School Based Health Centers (SBHCs) in Oregon serviced by Multnomah County Health Department (MC) clinics. All clusters start in control and cross over in a randomized, staggered fashion, with all eventually receiving the intervention.

Study Record Dates

• First Submitted: February 6, 2026
• First Posted: February 17, 2026
• Study Start: January 12, 2026
• Primary Completion (Estimated): August 1, 2028
• Study Completion (Estimated): June 1, 2029
• Last Updated: May 1, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)