The Effect of Different Irrigation Methods Used During Endodontic Treatment on Postoperative Pain in Teeth With Periapical Lesions

NCT07410832 | Completed

• 2 other identifiers: 759No secondary ID
• Study Type: interventional
• Target: 88
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to evaluate the effect of different irrigation activation methods used during endodontic treatment on postoperative pain in teeth with periapical lesions, allowing us to clinically determine which agitation technique causes less postoperative pain.

Conditions

Mandibular Premolars and Canines With Asymptomatic Apical Periodontitis

Keywords

postoperative pain; periapical lesion; activation tecniques; irrigation

Outcome Measures

Primary Outcomes (1)

• Assessment of postoperative pain with VAS after root canal treatment

  6, 24, 48, 72 hours, and on the 7th day

Study Arms (4)

Irrigation using conventional needle technique

EXPERIMENTAL

Irrigation of the root canals was performed using only the conventional needle technique

Procedure: Irrigation

Irrigation using the Eddy system

EXPERIMENTAL

"Irrigation activation of the root canals was performed using the EDDY system

Procedure: Irrigation

Irrigation using ultrasonic activation

EXPERIMENTAL

Root canal irrigation activation was performed using ultrasonic activation."

Procedure: Irrigation

Irrigation using XP Finisher system

EXPERIMENTAL

Root canal irrigation activation was performed using the XP Finisher system.

Procedure: Irrigation

Interventions

Irrigation PROCEDURE

Irrigation procedures were performed with needles of different ırrigation devices

Irrigation using XP Finisher system; Irrigation using conventional needle technique; Irrigation using the Eddy system; Irrigation using ultrasonic activation

Eligibility Criteria

• Age: 15 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Healthy patients aged 18-65 years, Patients with chronic apical periodontitis, Patients with a PAI score of 3-5, Mandibular canine and premolar teeth, Teeth without root resorption, periodontal disease, previous endodontic treatment, or calcification.

You may not qualify if:

• Patients with systemic diseases, Pregnant patients, Teeth with acute pain, Teeth with crown or root fractures, Patients who have used analgesic or anti-inflammatory drugs within the last 12 hours, Patients who have used antibiotics within the last 2 weeks, Immature teeth with open apices, Patients with missing consent or follow-up forms.

Sponsors & Collaborators

• Akdeniz University: lead

Study Sites (1)

Akdeniz University Faculty of Dentistry Department of Endodontics

Antalya, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Pain, Postoperative

Interventions

Therapeutic Irrigation

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Hydrotherapy; Physical Therapy Modalities; Therapeutics; Rehabilitation; Investigative Techniques

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assoc. Prof.

Study Record Dates

• First Submitted: February 6, 2026
• First Posted: February 13, 2026
• Study Start: June 1, 2025
• Primary Completion: October 30, 2025
• Study Completion: December 30, 2025
• Last Updated: February 13, 2026

Record last verified: 2026-02

Locations

TU (1)