Effectiveness and Implementation of a Community-based Health Coach-led Artificial Intelligence (AI)-Powered Digital Self-Regulation Program for Individuals With Metabolic Syndrome (MetS)

NCT07410325 | Recruiting

• 1 other identifier: NUS-IRB-2024-866
• Study Type: interventional
• Target: 316
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to evaluate the effectiveness of the Lifestyle Intervention for Gentle, Healthy Transformation and Enhanced Weight Reduction-metabolic syndrome (LIGHTER-MetS) program on dietary self-regulation and cardiovascular risk among individuals with metabolic syndrome (MetS). The LIGHTER-MetS program, a community-based, grassroots-led initiative, integrates health coaching with the eTRIP© app to promote sustainable lifestyle changes focusing on diet, exercise, and emotion regulation.

Conditions

Metabolic Syndrome (MetS); Metabolic Syndrome

Outcome Measures

Primary Outcomes (2)

• Self regulation of Eating Behaviour Questionnaire (SREBQ)

  The Self-Regulation of Eating Behaviour Questionnaire (SREBQ) is a validated self-administered instrument used to assess individuals' self-regulation in relation to eating behavior. It evaluates the extent to which individuals monitor, control, and regulate their eating behaviors in everyday contexts. Higher scores indicate greater self-regulation of eating behavior.

  At baseline, 3, 6, and 12 months.

• Cardiovascular Risk

  Cardiovascular risk will be assessed via the ASCVD-risk calculator and the Singapore-modified Framingham Risk Score 2023 (SG-FRS-2023). Higher scores indicate a greater estimated cardiovascular risk.

  At baseline, 3, 6, and 12 months.

Secondary Outcomes (21)

• Weight

  At baseline, 3, 6, and 12 months.

• Waist Circumference

  At baseline, 3, 6, and 12 months.

• Blood Pressure

  At baseline, 3, 6, and 12 months.

• Three Factor Eating Questionnaire (TFEQ)

  At baseline, 3, 6 and 12 month.

• Consideration of Future Consequences Scale (CFCS-6)

  At baseline, 3, 6 and 12 month.

Study Arms (2)

LIGHTER-MetS

EXPERIMENTAL

The LIGHTER-MetS program includes community-based health coaching by the PI or a trained healthcare professional (e.g. nurse, physiotherapist etc.) at baseline visit and for 3 months following the baseline visit. Throughout the first 3 months, participants will also use the eTRIP© app to log meals, monitor physical activity, and receive personalized feedback. During the 3-month intervention period, there will be one-to-one slots for the health coach to follow up on participants' health plan.

Behavioral: LIGHTER-MetS

Control

NO INTERVENTION

Participants will receive personalised health plans provided as part of usual care when they see a family physician. As part of the HealthierSG initiative, health plans are typically formulated to target early disease prevention and chronic condition management through history taking, physical examination, appropriate diagnostic testing, treatment, referrals and lifestyle modification goals and activity planning.

Interventions

LIGHTER-MetS BEHAVIORAL

The LIGHTER-MetS program includes community-based health coaching by the PI or a trained healthcare professional (e.g. nurse, physiotherapist etc.) at baseline visit and for 3 months following the baseline visit. Throughout the first 3 months, participants will also use the eTRIP© app to log meals, monitor physical activity, and receive personalized feedback. During the 3-month intervention period, there will be one-to-one slots for the health coach to follow up on participants' health plan.

LIGHTER-MetS

Eligibility Criteria

• Age: 21 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• are between 21 to 65 years of age;
• have a waist circumference ≥90 cm in men and ≥80 cm in women;
• have 2 or more of the following to be classified as having metabolic syndrome:
• triglyceride level of ≥1.7 mmol/L or on specific treatment for this lipid abnormality;
• high density lipoprotein (HDL) cholesterol \<1.03 mmol/L in men, and \<1.29 mmol/L in women, or on specific treatment for this lipid abnormality;
• blood pressure of ≥130/85 mmHg or on treatment of previously diagnosed hypertension;
• fasting blood glucose level of ≥ 5.6 mmol/L or previously diagnosed type 2 diabetes;
• are not receiving other structured lifestyle modification programs;
• consent to audio-recording;
• English speaking and literate.

You may not qualify if:

• underwent or are scheduled for metabolic surgery within 1 year;
• are pregnant or planning for pregnancy at the time of recruitment;
• are unable to speak English;
• do not own a smartphone; and
• are unable to provide informed consent.

Sponsors & Collaborators

• National University Health System, Singapore: lead

Study Sites (1)

National University of Singapore

Singapore, 117597, Singapore

RECRUITING

MeSH Terms

Conditions

Metabolic Syndrome

Condition Hierarchy (Ancestors)

Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Central Study Contacts

Jocelyn Chew

CONTACT

+6565168687; dbi-lab@nus.edu.sg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: June 24, 2025
• First Posted: February 13, 2026
• Study Start: January 1, 2026
• Primary Completion (Estimated): January 1, 2027
• Study Completion (Estimated): January 1, 2027
• Last Updated: April 8, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

SG (1)