Effect of Injectable Platelet Rich Derivatives on Orthodontic Canine Retraction

NCT07408895 | Completed

• 1 other identifier: SU-DENT-001
• Study Type: interventional
• Target: 21
• Locations: 1 country
• Sites: 1

Brief Summary

This study evaluated the effect of injectable platelet-rich derivatives on the rate of orthodontic canine retraction. Patients requiring orthodontic canine retraction following premolar extraction were enrolled and divided into three groups using a split-mouth design. Injectable platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) were applied to compare their effects on the rate of tooth movement. The outcomes were assessed by measuring the amount of canine retraction over time.

Conditions

Accelerate Tooth Movement

Outcome Measures

Primary Outcomes (1)

• Rate of Orthodontic Canine Retraction

  The amount of orthodontic canine movement measured in millimeters.

  From baseline (initiation of orthodontic canine retraction) until completion of canine retraction, assessed monthly for up to 4 months.

Study Arms (2)

PRP vs Control (Split-Mouth)

EXPERIMENTAL

Split-mouth group in which one side received platelet-rich plasma (PRP) injection and the contralateral side served as a control without injection during orthodontic canine retraction.

Biological: Platelet-Rich Plasma (PRP)

PRF vs Control (Split-Mouth)

EXPERIMENTAL

Split-mouth group in which one side received platelet-rich fibrin (PRF) injection and the contralateral side served as a control without injection during orthodontic canine retraction.

Biological: Platelet-Rich Fibrin (PRF)

Interventions

Platelet-Rich Plasma (PRP) BIOLOGICAL

Autologous platelet-rich plasma prepared from the patient's own blood and injected locally at the experimental side to accelerate orthodontic canine retraction.

PRP vs Control (Split-Mouth)

Platelet-Rich Fibrin (PRF) BIOLOGICAL

Autologous platelet-rich fibrin prepared from the patient's own blood and injected locally to accelerate orthodontic canine retraction.

PRF vs Control (Split-Mouth)

Eligibility Criteria

• Age: 17 Years - 29 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Healthy individuals aged 17-29 years (mean age 24 ± 6 years)
• Diagnosis of Class I bimaxillary protrusion or Class II division 1 requiring first premolar extractions
• Full permanent dentition
• Good oral hygiene
• Non-smokers
• Not taking medications affecting bone metabolism (e.g., bisphosphonates)

You may not qualify if:

• Pregnancy or breastfeeding
• Contraindications to platelet therapies (e.g., platelet dysfunction)
• Severe malocclusion unsuitable for fixed appliances
• Dental anomalies (size/shape)
• Systemic syndromes

Sponsors & Collaborators

• Sana'a University: lead

Study Sites (1)

Faculty of Dentistry, Sana'a University

Sanaa, Yemen

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Split-mouth randomized controlled design in which different interventions were applied to opposite sides within the same participant.

Study Record Dates

• First Submitted: January 26, 2026
• First Posted: February 13, 2026
• Study Start: May 30, 2024
• Primary Completion: September 5, 2024
• Study Completion: September 5, 2024
• Last Updated: February 13, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

YE (1)