Accelerated Orthodontics With Alveolar Decortication Plus CGF Injection

NCT06975358 | Recruiting DMC

• 1 other identifier: #R-OS-12-24-3158
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of the present study is to evaluate alveolar bone decortication combined with CGF Injection on tooth movement acceleration

Conditions

Accelerate Tooth Movement

Outcome Measures

Primary Outcomes (1)

• rate of canine retraction

  4 months

Study Arms (2)

Alveolar decortication plus CGF

EXPERIMENTAL

Alveolar decortication followed by submucosal CGF injection (70 units) disto-buccal and disto-palatal to the maxillary canine will be randomly assigned to one side of the maxillary arch (experimental) while the other side serve as (control) receiving orthodontic treatment without any additional intervention

Procedure: Alveolar decortication plus CGF injection

Control

ACTIVE COMPARATOR

the other side of the maxillary arch will receive the usual orthodontic treatment without any additional intervention

Procedure: canine retraction without acceleration

Interventions

Alveolar decortication plus CGF injection PROCEDURE

Experimental sides will receive CGF injection (70 units) disto-buccal and disto-palatal to the maxillary canine after performing decortication. After administration of local anesthesia, two-line flap will be performed from the mesial surface of the maxillary second premolar to the distal surface of the maxillary canine Mucoperiosteal flap will be reflected in the buccal side. Two millimeters of marginal crestal bone will be held intact and using a high-speed drill and a round carbide bur (1mm diameter) under copious saline irrigation, the cortical wall will be penetrated to reach marrow spaces. Multiple perforations (10 holes for standardization) in the cortical bone will be created. The surgical site will then rinsed, and the flap will be repositioned and sutured.

Alveolar decortication plus CGF

canine retraction without acceleration PROCEDURE

in the control side, the maxillary canine will be retracted without any acceleration procedure

Control

Eligibility Criteria

• Age: 16 Years - 22 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Age of the patients ranged from 16: 22 years old.
• Malocclusion that requires extraction of the maxillary first premolar and canine retraction (e.g. class I bimaxillary dentoalveolar protrusion and class II div 1 malocclusion).
• Maximum anchorage needed for the maxillary arch as a part of the orthodontic treatment plan.
• Good oral hygiene and periodontal condition.

You may not qualify if:

• Medically compromised patients.
• Severe crowding in the maxillary arch.
• Chronic intake of NSAIDs or any medication that interfere with OTM.
• Previous orthodontic treatment.

Sponsors & Collaborators

• Safa Basiouny Alawy: lead

Study Sites (1)

Tanta University

Tanta, Tanta, 6624033, Egypt

RECRUITING

MeSH Terms

Interventions

Acceleration

Intervention Hierarchy (Ancestors)

Motion; Physical Phenomena

Central Study Contacts

Safa B Alawy, PhD

CONTACT

0201009088252; safa_basyouny@dent.tanta.edu.eg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Lecturer of Orthodontics

Study Record Dates

• First Submitted: May 8, 2025
• First Posted: May 16, 2025
• Study Start: May 20, 2025
• Primary Completion: October 1, 2025
• Study Completion: November 1, 2025
• Last Updated: June 27, 2025

Record last verified: 2025-06

Locations

EG (1)