Comparative Effects of CGF and PRP in Impacted Third Molar Surgery

NCT07320170 | Completed

• 1 other identifier: 2024/52
• Study Type: interventional
• Target: 42
• Locations: 1 country
• Sites: 1

Brief Summary

This study evaluates the effects of two different blood products obtained from the patient's own blood (Concentrated Growth Factor \[CGF\] and Platelet-Rich Plasma \[PRP\]) on healing after wisdom tooth extraction. The aim is to determine whether applying these materials to the extraction area reduces postoperative pain, facial swelling, and the risk of dry socket compared to standard healing.

Conditions

Impacted Third Molar

Keywords

Third Molar Surgery; PRP; CGF

Outcome Measures

Primary Outcomes (1)

• Postoperative Pain

  Assessed using a Visual Analog Scale (VAS) ranging from 0 (no pain) to 10 (worst pain imaginable).

  Postoperative days 1, 3, and 7.

Secondary Outcomes (2)

• Facial Swelling

  Preoperative and Postoperative days 1, 3, and 7.

• Incidence of Alveolar Osteitis

  Postoperative days 1, 3, and 7

Study Arms (3)

Control Group

NO INTERVENTION

Standard surgical extraction was performed without the application of any additional biomaterials.

CGF Group

EXPERIMENTAL

Standard surgical extraction followed by the placement of a Concentrated Growth Factor (CGF) clot into the extraction socket.

Biological: Concentrated Growth Factor (CGF)

PRP Group

EXPERIMENTAL

Standard surgical extraction followed by submucosal injection of Platelet-Rich Plasma (PRP).

Biological: Platelet-Rich Plasma (PRP)

Interventions

Concentrated Growth Factor (CGF) BIOLOGICAL

Standard surgical extraction followed by the placement of a Concentrated Growth Factor (CGF) clot into the extraction socket immediately after tooth removal.

CGF Group

Platelet-Rich Plasma (PRP) BIOLOGICAL

Standard surgical extraction followed by submucosal injection of Platelet-Rich Plasma (PRP) around the extraction site.

PRP Group

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Patients aged between 18 and 50 years.
• Systemically healthy individuals classified as American Society of Anesthesiologists (ASA) Class I or Class II.
• Presence of impacted mandibular third molars (teeth 38 and 48 according to Fédération Dentaire Internationale (FDI) notation).
• Mesioangular impaction with bone retention according to Winter's classification.
• Class II relationship to the ramus according to the Pell and Gregory classification.
• Level B or Level C depth of impaction according to the Pell and Gregory classification.

You may not qualify if:

• Patients younger than 18 years.
• Habitual smoking or alcohol consumption.
• Presence of coagulation (bleeding) disorders.
• Systemic diseases affecting wound healing or use of medications that compromise healing.
• Pregnancy or lactation.
• Presence of active pericoronitis associated with the tooth.
• Presence of pathological lesions (cysts or tumors) associated with the impacted tooth.
• Uncontrolled periodontal disease in the oral cavity.
• Known allergy to any medications used in the study protocol.
• Inability to comply with follow-up visits.

Sponsors & Collaborators

• Recep Tayyip Erdogan University: lead

Study Sites (1)

Recep Tayyip Erdogan University, Faculty of Dentistry

Rize, Turkey (Türkiye)

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: December 20, 2025
• First Posted: January 6, 2026
• Study Start: May 2, 2024
• Primary Completion: May 2, 2025
• Study Completion: May 2, 2025
• Last Updated: January 8, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)