M-TAPA vs ESPB for Postoperative Analgesia After Laparoscopic Cholecystectomy

NCT07403682 | Completed

• 1 other identifier: BCS-MTAPA-01
• Study Type: interventional
• Target: 124
• Locations: 1 country
• Sites: 1

Brief Summary

Postoperative pain after laparoscopic cholecystectomy can negatively affect patient comfort, recovery, and opioid consumption. Regional abdominal wall blocks are commonly used as part of multimodal analgesia to improve postoperative pain control and reduce opioid-related side effects. The modified thoracoabdominal nerve block through the perichondrial approach (M-TAPA) and the erector spinae plane block (ESPB) are two ultrasound-guided regional anesthesia techniques that have been shown to provide effective postoperative analgesia in abdominal surgery. However, comparative clinical data between these two techniques in laparoscopic cholecystectomy are limited. This randomized, single-blind clinical trial aims to compare the postoperative analgesic effectiveness of M-TAPA and ESPB in adult patients undergoing elective laparoscopic cholecystectomy. Postoperative pain scores, opioid consumption, time to first analgesic requirement, and patient satisfaction will be evaluated.

Conditions

Cholecystectomy, Laparoscopic; Postoperative Pain

Keywords

Laparoscopic cholecystectomy; M-TAPA block; Erector spinae plane block (ESPB); Regional anesthesia; Postoperative analgesia; Opioid consumption

Outcome Measures

Primary Outcomes (1)

• Total Opioid Consumption in the First 24 Hours

  Total cumulative opioid consumption within the first 24 hours after surgery, recorded as intravenous tramadol equivalent dose.

  within the first 24 hours postoperatively

Secondary Outcomes (7)

• Pain intensity at rest (NRS)

  PACU, 3, 6, 12, 18, and 24 hours postoperatively

• Pain intensity during movement (NRS)

  PACU, 3, 6, 12, 18, and 24 hours postoperatively

• Rescue analgesic requirement

  Within the first 24 hours postoperatively

• Postoperative nausea and vomiting (PONV)

  At postoperative hours 0, 6, 12, and 24

• Time to first rescue analgesia

  Within the first 24 hours postoperatively

Study Arms (2)

M-TAPA Block

EXPERIMENTAL

An ultrasound-guided modified thoracoabdominal nerve block through the perichondrial approach (M-TAPA) performed bilaterally using local anesthetic for postoperative analgesia after laparoscopic cholecystectomy.

Procedure: Modifiye throcoabdominal nerve block through the perichondrial approach (M-TAPA)

ESPB

EXPERIMENTAL

An ultrasound-guided erector spinae plane block (ESPB) performed using local anesthetic for postoperative analgesia after laparoscopic cholecystectomy.

Procedure: erector spinae plane block (ESPB)

Interventions

Modifiye throcoabdominal nerve block through the perichondrial approach (M-TAPA) PROCEDURE

An ultrasound-guided modified thoracoabdominal nerve block through the perichondrial approach (M-TAPA) performed bilaterally using local anesthetic for postoperative analgesia after laparoscopic cholecystectomy.

M-TAPA Block

erector spinae plane block (ESPB) PROCEDURE

An ultrasound-guided erector spinae plane block (ESPB) performed using local anesthetic for postoperative analgesia after laparoscopic cholecystectomy.

ESPB

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adult patients aged 18-65 years
• ASA physical status I-II
• Scheduled for elective laparoscopic cholecystectomy under general anesthesia
• Ability to understand the study procedures and provide written informed consent

You may not qualify if:

• Refusal to participate
• Known allergy to local anesthetics
• Coagulation disorders or anticoagulant therapy
• Infection at the injection site
• Severe hepatic, renal, or cardiac disease
• Chronic opioid use

Sponsors & Collaborators

• Başakşehir Çam & Sakura City Hospital: lead

Study Sites (1)

Başakşehir Çam and Sakura City Hospital

Istanbul, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Pain, Postoperative

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: Participants were blinded to treatment allocation. Postoperative outcome assessments, including pain scores, QoR-15, patient satisfaction, and postoperative nausea and vomiting, were performed by an independent investigator who was blinded to group allocation. The anesthesiologist performing the assigned block was aware of the intervention but was not involved in postoperative data collection or outcome assessment.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 4, 2026
• First Posted: February 11, 2026
• Study Start: March 3, 2026
• Primary Completion: May 23, 2026
• Study Completion: May 23, 2026
• Last Updated: August 21, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)