Serratus Posterior Superior vs Erector Spinae Plane Block for Breast Surgery

NCT07561853 | Not Yet Recruiting

• 1 other identifier: SAU-ANE-MGK-01
• Study Type: interventional
• Target: 64
• Locations: 0 countries
• Sites: N/A

Brief Summary

Postoperative pain after mastectomy remains a significant clinical problem that may impair patient comfort and delay early rehabilitation, potentially affecting functional recovery. Various analgesic techniques are used to manage postoperative pain. This study aims to compare serratus posterior superior intercostal plane block and erector spinae plane block, which are routinely used in our clinic for postoperative analgesia in patients undergoing mastectomy, in terms of ease of application and patient comfort.

Conditions

Postoperative Pain

Keywords

Serratus Posterior Superior Intercostal Plane Block; Erector Spinae Plane Block; Mastectomy; Postoperative Pain; Fascial Plane Block

Outcome Measures

Primary Outcomes (1)

• Ease of block application (procedure difficulty score)

  The ease of application of the block will be evaluated using a 10-point numerical rating scale (0-10), where lower scores indicate easier application and higher scores indicate greater procedural difficulty. The score will be assigned by the anesthesiologist performing the block immediately after completion of the procedure.

  Immediately after block performance

Secondary Outcomes (2)

• Postoperative pain score at 24 hours

  24 hours postoperatively

• Quality of recovery at 24 hours

  24 hours postoperatively

Study Arms (2)

Serratus Posterior Superior Intercostal Plane Block Group

EXPERIMENTAL

Participants in this group will receive an ultrasound-guided serratus posterior superior intercostal plane (SPSIP) block for postoperative analgesia following mastectomy. The block will be performed under standardized conditions prior to surgery according to the study protocol.

Procedure: Serratus posterior superior intercostal plane block

Erector Spinae Plane Block Group

EXPERIMENTAL

Participants in this group will receive an ultrasound-guided erector spinae plane (ESP) block for postoperative analgesia following mastectomy. The block will be performed under standardized conditions prior to surgery according to the study protocol.

Procedure: Erector Spinae Plane Block

Interventions

Serratus posterior superior intercostal plane block PROCEDURE

Participants in this group will receive an ultrasound-guided serratus posterior superior intercostal plane (SPSIP) block for postoperative analgesia following mastectomy. The block will be performed under standardized conditions prior to surgery according to the study protocol.

Serratus Posterior Superior Intercostal Plane Block Group

Erector Spinae Plane Block PROCEDURE

Participants in this group will receive an ultrasound-guided erector spinae plane (ESP) block for postoperative analgesia following mastectomy. The block will be performed under standardized conditions prior to surgery according to the study protocol.

Erector Spinae Plane Block Group

Eligibility Criteria

• Age: 25 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients aged 25-65 years American Society of Anesthesiologists (ASA) physical status I-III Patients scheduled for mastectomy under general anesthesia Patients with no history of previous breast surgery Patients who provide written informed consent to participate in the study

You may not qualify if:

• ASA physical status IV and above History of alcohol or substance abuse Known allergy to local anesthetics or opioids Patients with severe psychiatric disorders Patients who refuse to participate or do not provide informed consent

Sponsors & Collaborators

• Sakarya University: lead

MeSH Terms

Conditions

Pain, Postoperative

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR
• Masking Details: This study is designed as a triple-blind trial. Participants, perioperative care providers, and outcome assessors will be blinded to group allocation. Randomization will be performed using a computer-generated sequence, and group assignments will be concealed in sealed, opaque envelopes. The anesthesiologist performing the block will not be involved in postoperative care or outcome assessment. To maintain blinding, block procedures will be performed under standardized conditions, and patients will not be informed about the specific block type administered. Outcome data will be collected by investigators who are unaware of the assigned intervention.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Anesthesiology Specialist

Model Details: Participants will be randomly assigned to one of two parallel groups to receive either a serratus posterior superior intercostal plane (SPSIP) block or an erector spinae plane (ESP) block for postoperative analgesia following mastectomy. The study is designed as a parallel-group trial. Randomization will be performed using a computer-generated sequence. Blinding will be maintained such that the patient, the care providers responsible for perioperative management, and the outcome assessors are unaware of group allocation. Only the anesthesiologist performing the block will be aware of the assigned intervention and will not be involved in postoperative data collection or outcome assessment.

Study Record Dates

• First Submitted: April 24, 2026
• First Posted: May 1, 2026
• Study Start (Estimated): June 1, 2026
• Primary Completion (Estimated): November 15, 2026
• Study Completion (Estimated): December 15, 2026
• Last Updated: May 1, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share