External Oblique Intercostal Block Versus Transversus Abdominis Plane Combined With Rectus Sheath Block on Postoperative Pain in Laparoscopic Radical Gastrectomy

NCT07496086 | Recruiting DMC

• 1 other identifier: Lingzi-2026-2
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Postoperative pain is highly prevalent following laparoscopic radical gastrectomy. Although Transversus abdominis plane block combined with rectus sheath block(TAP+RSB） can effectively alleviate this pain, it still has many limitations. The external oblique intercostal plane block (EOIB) is a novel nerve block technique that may provide well postoperative analgesia for upper abdominal surgery. Therefore, this study employs a non-inferiority randomized controlled trial design to verify that the analgesic effect of EOIB is not inferior to that of ESPB, thereby offering more options for regional analgesia strategies in laparoscopic radical gastrectomy.

Conditions

Postoperative Pain

Outcome Measures

Primary Outcomes (1)

• Cumulative opioid consumption within 24 hours postoperatively

  Cumulative opioid consumption within 24 hours postoperatively. Conversion to morphine equivalent dose (mg)

  24 hours after surgery

Secondary Outcomes (3)

• Pain Intensity

  2, 6, 12, 24, 48, and 72 hours postoperatively

• Quality of Recovery

  24,48,72 hours after surgery

• sleep quality

  24,48,72 hours after surgery

Study Arms (2)

EOIB

EXPERIMENTAL

After patients entering the operating room, an intravenous line was established, and External Oblique Intercostal Plane Block was performed under ultrasound guidance.

Procedure: EOIB

TAP+RSB

EXPERIMENTAL

After patients entering the operating room, an intravenous line was established, and Transversus abdominis plane block combined with rectus sheath block was performed under ultrasound guidance.

Procedure: TAP+RSB

Interventions

EOIB PROCEDURE

With the patient in the supine position, a high-frequency linear array probe (6-15 MHz) is used to perform a sagittal parasagittal oblique scan at the level of the 6th rib, between the right anterior axillary line and midclavicular line. The external oblique muscle, intercostal muscles, and ribs are identified. Using an in-plane technique, a 21G, 100mm block needle is inserted from a superomedial to inferolateral direction, with the needle tip positioned in the plane between the external oblique muscle and the intercostal muscles at the caudal edge of the 6th rib. 30ml of 0.375% ropivacaine is injected on each side, for a bilateral administra

EOIB

TAP+RSB PROCEDURE

With the patient in the supine position, above the umbilicus, a linear ultrasound transducer was positioned transversely on the rectus abdominis muscle, and 15 mL of ropivacaine 0.375% was injected into both sides of the aspect between the rectus abdominis muscle and the posterior rectus sheath with a 22G 70-mm block needle using the in-plane technique. At the midaxillary line, a linear ultrasound transducer was positioned close and parallel to the lower costal margin. In the bilateral aspect between the internal oblique and transversus abdominis muscles, 15 mL of ropivacaine 0.375% was injected on each side with a 22G 70-mm block needle.

TAP+RSB

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients aged over 18 years
• Classified as ASA I-III
• Scheduled for elective laparoscopic radical gastrectomy under general anesthesia
• Voluntarily participated and provided written informed consent.

You may not qualify if:

• Chronic opioid dependence or prior use of analgesic medications for \>3 months;
• Inability to communicate due to severe dementia, language barriers, or terminal illness;
• History of central and/or peripheral nervous system disorders;
• Severe renal insufficiency (serum creatinine \>442 μmol/L or requiring renal replacement therapy) or severe hepatic insufficiency (Child-Pugh class C);
• Allergy to local anesthetics.
• Expected to be transferred to ICU after surgery.
• Refuse patient control agenesia after surgery.

Sponsors & Collaborators

• General Hospital of Ningxia Medical University: lead

Study Sites (1)

General hospital of Ningxia medical university

Yinchuan, China

RECRUITING

MeSH Terms

Conditions

Pain, Postoperative

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Study Officials

• lingzi Yin

  General hospital of Ningxia medical university, Yinchuan, Ningxia

  STUDY DIRECTOR

Central Study Contacts

lingzi Yin, Doctoral

CONTACT

86-951-674-3252; eleven87670@163.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: On the day of surgery, after the induction of general anesthesia, the study coordinator opened the corresponding envelope in the order of recruitment. Patients were randomly assigned to receive either EOIB or TAP+RSB, which was performed preoperatively by an experienced anesthesiologist. The anesthesiologist was aware of the intervention, but all patients, data investigator and postoperative follow-up remained blinded to group assignment.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 22, 2026
• First Posted: March 27, 2026
• Study Start: March 20, 2026
• Primary Completion (Estimated): October 30, 2026
• Study Completion (Estimated): November 3, 2026
• Last Updated: March 27, 2026

Record last verified: 2026-03

Locations

CN (1)