Comparison of the Combined Serratus Anterior Plane Block Versus Superficial Serratus Anterior Plane Block

NCT07394868 | Not Yet Recruiting

• 1 other identifier: Etlik Kübra Tez
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Breast cancer is the most common malignancy in women; surgery is a cornerstone of breast cancer treatment, and modified radical mastectomy is one of the standard treatments. Postoperative pain can significantly reduce the quality of life in patients, and acute pain can even trigger chronic pain syndrome. Thoracic paravertebral, thoracic epidural, intercostal nerve, and interscalene brachial plexus blocks have been used for anesthesia and abiration during modified radical mastectomy, but their application is limited due to the complex nature of the procedures and serious complications. In recent years, there has been increasing interest in the newer, less invasive superficial serratus block and combined serratus block. Serratus anterior plane block (SAPB) can be applied in two ways. Deep SPB (DSPB) is applied under the serratus anterior muscle, while superficial SPB (YSPB) is applied above the serratus anterior muscle. In recent years, deep + superficial SPB, or combined SPB (KSPB), has begun to be applied in order to increase the area of effect of local anesthetics and to prevent block failure. This study aims to compare superficial and combined serratus anterior plane blocks.

Conditions

Pain

Keywords

Breast surgery; Multimodal analgesia; Serratus anterior plane block

Outcome Measures

Primary Outcomes (1)

• Opioid consumption

  Patients will be monitored for 24-hour opioid consumption with patient-controlled analgesia.

  24 hours postoperative

Secondary Outcomes (6)

• Numeric Rating Scale (NRS)

  1 hour

• Numeric Rating Scale (NRS)

  2 hour

• Numeric Rating Scale (NRS)

  4 hour

• Numeric Rating Scale (NRS)

  12 hour

• Numeric Rating Scale (NRS)

  24 hour

Study Arms (2)

Combined superficial and deep serratus anterior plane block

Patients who will undergo combined serratus anterior plane block will be included in this group.

Other: Combined serratus plan block

Superficial serratus anterior plane block

Patients who will undergo a superficial anterior plane serratus block will be included in this group.

Other: Superficial serratus plane block

Interventions

Combined serratus plan block OTHER

Combined serratus plan block

Combined superficial and deep serratus anterior plane block

Superficial serratus plane block OTHER

Superficial serratus plane block

Superficial serratus anterior plane block

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who undergone mastectomy surgery

You may qualify if:

• Individuals aged 18-80 years
• Individuals with ASA scores I-II-III
• Individuals with a Body Mass Index (BMI) between 18-40

You may not qualify if:

• Individuals under 18 years of age and over 80 years of age
• Individuals with an ASA score of IV or higher
• Individuals with advanced comorbidities
• Individuals with a history of bleeding diathesis
• Patients with infection in the area to be blocked
• Individuals with a BMI below 18 and above 40

Sponsors & Collaborators

• Ankara Etlik City Hospital: lead

Study Sites (1)

Ankara Etlik City Hospital

Ankara, Varlık Mahallesi, Halil Sezai Erkut Caddesi Yenimahalle, 06170, Turkey (Türkiye)

Location

Related Publications (3)

• Chai B, Wang Q, Du J, Chen T, Qian Y, Zhu Z, Feng Z, Kang X. Research Progress on Serratus Anterior Plane Block in Breast Surgery: A Narrative Review. Pain Ther. 2023 Apr;12(2):323-337. doi: 10.1007/s40122-022-00456-z. Epub 2022 Dec 9.

  PMID: 36484891 BACKGROUND

• Ozguner Y, Yazar CO, Aydin F, Zengin M, Arik E, Kotanoglu MS, Altinsoy S, Ergil J. Comparison of the analgesic efficacy of combined superficial and deep serratus anterior plane block versus pectoserratus plane block following modified radical mastectomy surgery. BMC Anesthesiol. 2025 Jul 28;25(1):358. doi: 10.1186/s12871-025-03213-9.

  PMID: 40721998 RESULT

• Ulger G, Zengin M, Kucuk O, Baldemir R, Kaybal O, Tunc M, Sazak H, Alagoz A. Comparison of combined deep and superficial serratus anterior block with thoracic paravertebral block for postoperative pain in patients undergoing video-assisted thoracoscopic surgery. Turk J Med Sci. 2024 Aug 4;54(5):1021-1032. doi: 10.55730/1300-0144.5881. eCollection 2024.

  PMID: 39473759 RESULT

MeSH Terms

Conditions

Pain

Condition Hierarchy (Ancestors)

Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Yusuf Ozguner

  Ankara Etlik City Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Yusuf Ozguner

CONTACT

05427150725; y.ozguner@hotmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: January 31, 2026
• First Posted: February 6, 2026
• Study Start: February 15, 2026
• Primary Completion (Estimated): July 15, 2026
• Study Completion (Estimated): August 15, 2026
• Last Updated: February 11, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)