Study of the Association Between Sacroiliitis/Axial Spondylarthritis and Giant Cell Arteritis/ Polymyalgia Rheumatica

NCT07394478 | Not Yet Recruiting

• 1 other identifier: CHRD 1625
• Study Type: observational
• Target: 10
• Locations: 1 country
• Sites: 2

Brief Summary

The purpose of the study is to recruit as many patients as possible presenting with sacroiliitis or authentic axial spondylarthritis and giant cell arteritis. The investigators will also be interested in the association of spondylarthritis and polymyalgia rheumatica given the continuum between these two pathologies. The aim is to investigate whether there is an association between giant cell arteritis and spondylarthritis or polymyalgia rheumatica and spondylarthritis.

Conditions

Giant Cell Arteritis (GCA); Spondylarthritis; Polymyalgia Rheumatica

Keywords

Giant Cell Arteritis (GCA); Spondylarthritis; Polymyalgia rheumatica

Outcome Measures

Primary Outcomes (1)

• Description of the population of patients with spondylarthritis associated with giant cell arteritis (GCA) or polymyalgia rheumatica (PMR) versus patients with GCA or PMR alone

  Identification of demographic or phenotypic factors different between experimental and control populations.

  At baseline

Study Arms (1)

Patients with GCA, spondylarthritis and/or polymyalgia rheumatica

Patients with GCA, spondylarthritis and/or polymyalgia rheumatica

Other: Description of population

Interventions

Description of population OTHER

Description of population in the aim of identify demographic or phenotypic factors different between experimental and control populations.

Patients with GCA, spondylarthritis and/or polymyalgia rheumatica

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

\- Experimental group: Adult patient with spondylitis associated with GCA or PMR Control group: Adult patient with GCA or PMR

You may qualify if:

• Experimental group: Adult patient with spondylitis associated with GCA or PMR Control group: Adult patient with GCA or PMR

You may not qualify if:

• Refusal to participate
• Positive anti CCP

Sponsors & Collaborators

• Hôpital NOVO: lead
• GEFA: collaborator
• CRI: collaborator

Study Sites (2)

CRI (Rheumatism and Inflammatory Club)

Paris, France

Location

GEFA (French Group for the study of large vessel Arteritis)

Toulouse, France

Location

Related Publications (15)

• L.A. Healey, Relation of giant cell arteritis to polymyalgia rheumatica, Baillière's Clinical Rheumatology, Volume 5, Issue 3, 1991, Pages 371-378, ISSN 0950-3579

  BACKGROUND

• Aydeniz A, Akaltun MS, Gur A, Gursoy S. [Coexistence of polymyalgia rheumatica with ankylosing spondylitis: A case report]. Agri. 2018 Jan;30(1):35-37. doi: 10.5505/agri.2016.69672. Turkish.

  PMID: 29450875 BACKGROUND

• Corli J, Lemeunier L, le Gouellec N, Flipo RM. Giant cell arteritis occurring during psoriatic arthritis treated by adalimumab. Joint Bone Spine. 2015;82:291-2.

  BACKGROUND

• 13 Clementz GL, Gold F, Khaiser N, ZolinWD, Jalovec L. Giant cell arteritis associated with pericarditis and pancreatic insufficiency in a patient with psoriatic arthritis. Rheumatol. 1989;16:128-9.

  BACKGROUND

• 12 Aortitis due to Giant Cell Arteritis and Psoriatic Arthritis: An Uncommon Association M. del Pilar García-Cezón de la Cruz,a Raquel Almodóvar,b,∗Javier García Pérez,c Patricia Fanny Dhimes,d Pedro Zarcob DOI: 10.1016/j.reumae.2016.03.013

  BACKGROUND

• Elkayam O, Paran D, Yaron M, Caspi D. Polymyalgia rheumatica in patients with ankylosing spondylitis: a report of 5 cases. Clin Exp Rheumatol. 1997;15:411-4.

  BACKGROUND

• Eshed I, Druyan A, Stern M, Bordavka M, Lidar M. The prevalence of sacroiliitis on abdominal MRI examinations of patients with Takayasu arteritis. Acta Radiol. 2022 Mar;63(3):387-392. doi: 10.1177/0284185121996270. Epub 2021 Apr 11.

  PMID: 33843285 BACKGROUND

• 8. Pawel Mielnik, Anja Myhre Hjelle, Jan Leidulv Nordeide, Coexistence of Takayasu's arteritis and ankylosing spondylitis may not be accidental - Is there a need for a new subgroup in the spondyloarthritis family?, Modern Rheumatology, Volume 28, Issue 2, 4 March 2018, Pages 313-318, https://doi.org/10.1080/14397595.2017.1341592 2018 Mar;28(2):313-318. doi: 10.1080/14397595.2017.1341592. Epub 2017 Jul 18.

  BACKGROUND

• 7. Abacar, K., Kaymaz-Tahra, S., Bayındır, Ö. et al. Frequency and the effects of spondyloarthritis-spectrum disorders on the clinical course and management of Takayasu arteritis: an observational retrospective study. Clin Rheumatol 43, 1571-1578 (2024). https://doi.org/10.1007/s10067-024-06939-y

  BACKGROUND

• Riviere E, Arnaud L, Ebbo M, Allanore Y, Claudepierre P, Dernis E, Ziza JM, Miceli-Richard C, Philippe P, Richez C, Soubrier M, Belkhir R, Seror R, Mariette X, Pavy S; Club Rhumatismes et Inflammations. Takayasu Arteritis and Spondyloarthritis: Coincidence or Association? A Study of 14 Cases. J Rheumatol. 2017 Jul;44(7):1011-1017. doi: 10.3899/jrheum.160762. Epub 2017 Apr 15.

  PMID: 28412700 BACKGROUND

• Gan FY, Fei YY, Li MT, Wang Q, Xu D, Hou Y, Zeng XF, Zhang FC. The characteristics of patients having ankylosing spondylitis associated with Takayasu's arteritis. Clin Rheumatol. 2014 Mar;33(3):355-8. doi: 10.1007/s10067-013-2444-7. Epub 2013 Dec 6.

  PMID: 24310108 BACKGROUND

• 4. Güzel Esen S, Armagan B, Atas N, Ucar M, Varan Ö, Erden A et al (2019) Increased incidence of spondyloarthropathies in patients with Takayasu arteritis: a systematic clinical survey. Joint Bone Spine 86(4):497-501. https://doi.org/10.1016/j.jbspin.2019. 01.020

  BACKGROUND

• 3. Kwon OC, Lee SW, Park YB, Oh JS, Lee SH, Hong S et al (2018) Extravascular manifestations of Takayasu arteritis: focusing on the features shared with spondyloarthritis. Arthritis Res Ther. 20(1):142. https://doi.org/10.1186/s13075-018-1643-7

  BACKGROUND

• 2. Momeni M, Taylor N and Tehrani M. Cardiopulmonary manifestations of ankylosing spondylitis. Int J Rheumatol 2011; 2011: 728471

  BACKGROUND

• 1. Ozkan Y. Cardiac involvement in ankylosing spondylitis. J Clin Med Res 2016; 8: 427-430

  BACKGROUND

MeSH Terms

Conditions

Giant Cell Arteritis; Spondylarthritis; Polymyalgia Rheumatica

Condition Hierarchy (Ancestors)

Vasculitis, Central Nervous System; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Arteritis; Vasculitis; Skin Diseases, Vascular; Skin Diseases; Skin and Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases; Spondylitis; Spinal Diseases; Bone Diseases; Musculoskeletal Diseases; Arthritis; Joint Diseases; Muscular Diseases; Rheumatic Diseases; Connective Tissue Diseases

Study Officials

• Omar AL TABAA

  Hôpital NOVO

  PRINCIPAL INVESTIGATOR

• Auriane CHADELAT

  Hôpital NOVO

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Mathilde WLODARCZYK

CONTACT

0033130754650; mathilde.wlodarczyk@ght-novo.fr

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 27, 2026
• First Posted: February 6, 2026
• Study Start: February 1, 2026
• Primary Completion (Estimated): June 30, 2026
• Study Completion (Estimated): June 30, 2026
• Last Updated: February 6, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

FR (2)