Ankylosing Spondylitis

NCT07396194 | Not Yet Recruiting

• 1 other identifier: Soh-Med-26-1-2MD
• Study Type: observational
• Target: 84
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this observational study is to measure the serum level of cytokines IL-17, IL-38,IL-41, and gene expression of HLA-B27 gene in ankylosing spondylitis patients and healthy control group. The main question it aims to answer is: Does the disease activity, severity, serum level of cytokines (IL-17, IL-38, and IL-41) are affected by the HLA-b27 gene positivity? Researchers will compare the serum level of cytokines IL-17, IL-38,IL-41, and gene expression of HLA-B27 gene in ankylosing spondylitis patients and healthy control group to see if there significant differences in serum levels of interleukins 17, 38, 41 in AS patients and healthy control group. .

Conditions

Ankylosing Spondylitis

Keywords

Interleukin 17; Interleukin 38; Interleukin 41; HLA- B27 gene

Outcome Measures

Primary Outcomes (5)

• collection of blood samples from paticipants

  from March 2026 to August 2026

• measurement of serum level of Interleukin 17 in participants

  From September 2026 to October 2026

• Measurement of serum level of Interleukin 38 in participants

  from September 2026 to October 2026

• measurement of serum level of Interleukin 41 in participants

  from September 2026 to October 2026

• measurement of gene expression of HLA- B27 gene in participants

  from October 2026 to December 2026

Study Arms (2)

Cases

Patients with Ankylosing spondylitis

Healthy Controls

Participants Without Ankylosing spondylitis

Eligibility Criteria

• Age: 16 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Participants will be recruited from the outpatient clinics of Rheumatology and Rehabilitation Department, Sohag University Hospitals.

You may qualify if:

• patients who are diagnosed clinically as ankylosing spondylitis (both active or stable), of either sex , who met the Assessment of Spondyloarthritis International Society (ASAS) criteria for axial spondyloarthritis.

You may not qualify if:

• Patients with any autoimmune disorder, chronic illnesses as diabetes mellitus, acute and chronic infectious diseases, malignancy.

Sponsors & Collaborators

• Sohag University: lead

Biospecimen

Retention: SAMPLES WITH DNA

Blood samples will be retained

MeSH Terms

Conditions

Spondylitis, Ankylosing

Condition Hierarchy (Ancestors)

Axial Spondyloarthritis; Spondylarthropathies; Spondylarthritis; Spondylitis; Spinal Diseases; Bone Diseases; Musculoskeletal Diseases; Ankylosis; Joint Diseases; Arthritis

Central Study Contacts

Alaa Ezzat Ahmed, Assisstant lecturer

CONTACT

00201008908404; alaa.ezzat@med.sohag.edu.eg

Dina Hamada Mohamed, Lecturer

CONTACT

00201119886946; dinahamada87@yahoo.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assisstant lecturer

Study Record Dates

• First Submitted: February 1, 2026
• First Posted: February 9, 2026
• Study Start: March 1, 2026
• Primary Completion (Estimated): December 30, 2026
• Study Completion (Estimated): March 1, 2027
• Last Updated: February 9, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share